Harnessing Movement Variability to Treat and Prevent Motor Related Disorder

利用运动变异性来治疗和预防运动相关疾病

• 批准号: 8625897
• 负责人: NIKOLAOS STERGIOU
• 金额: $ 202.73万
• 依托单位: UNIVERSITY OF NEBRASKA OMAHA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8625897
• 关键词: Autistic Disorder; Behavior; Centers of Research Excellence; Clinical; Clinical Investigator; Conflict (Psychology); Development; Diagnosis; Disease; Early Diagnosis; Elderly; Faculty; Gait; Human; Infant; Knowledge; Laboratories; Lead; Long-Term Effects; Mentors; Metric; Motion; Motor; Movement; Nebraska; Noise; Patients; Performance; Peripheral; Public Health; Rehabilitation therapy; Research; Research Infrastructure; Research Personnel; Research Project Grants; Risk; Scientist; Self Perception; Sensory; Source; Stimulus; Stroke; Survivors; System; Universities; Visual; Walking; base; career; clinical decision-making; fall risk; gaze; member; neuromuscular system; prevent; programs; restoration; simulation; virtual reality; visual stimulus

DESCRIPTION (provided by applicant): We propose to establish a center of biomedical research excellence at the University of Nebraska Omaha that will create the infrastructure and expertise base to explore the mechanisms of human movement variability in order to treat and prevent motor related disorders. This proposal involves four research projects, each lead by a junior faculty member who will be mentored by at least one senior faculty member who is an established clinical investigator. In Project 1, Dr. Myers proposes to identify an assessment metric for clinical decision making in patients with peripheral disease using gait variability. In Project 2, Dr. Mukherjee will investigate if Virtual Reality simulations providing perception of self-motion influence gait variability in stroke survivors. This research will identify if augmente visual inputs can help to remove sensory conflicts that commonly exist during gat rehabilitation. In Project 3, Dr. Qiao will explore if older adults who are at risk of falls will demonstrate improvements in gait variability that approach that of healthy young when walking with a variable visual stimulus, compared to an invariant visual stimulus and a random visual stimulus. The short and long-term effects of the three stimuli on gait variability and performance of adaptive gait tasks will be investigated. In Project 4, Dr. Kyvelidou will investigate if differencs exist between typically developing infants and infants at risk for autism in terms of developing postural sway variability and gaze behavior in the first year as well as their relationship to late presence of diagnosis. This information could allow the development of an early detection paradigm for autism and the advancement of foundational knowledge from which treatments for autism may be developed. A strong mentoring program is established for the junior investigators, enabling them to achieve successful independent careers. This Center builds on existing expertise on the study of human movement variability and utilizes a new dedicated building with state of-the art laboratories demonstrating strong institutional support. This COBRE will be perpetuated by the addition of new projects and investigators. The result will be a continuing, self-sustaining, and competitive research Center that will transform the research culture and stimulate excellence in UNO and throughout Nebraska. PUBLIC HEALTH RELANCE: Human movement variability has been largely ignored as a source of important clinical information and has been treated as noise and error in the motor system. However, altered human movement variability is found increasingly in a variety of motor related disorders indicating reduced adaptive capacity in the neuromuscular system. The scientists in this Center will determine optimal approaches for therapies grounded on the restoration of variability and complexity of movement that could be applied across a range of diseases

描述（由申请人提供）：我们建议在内布拉斯加大学奥马哈分校建立一个生物医学研究卓越中心，该中心将创建基础设施和专业知识基础，以探索人类运动变异性的机制，以治疗和预防运动相关疾病。该提案涉及四个研究项目，每个项目均由一名初级教员领导，并由至少一名资深临床研究员指导。在项目 1 中，迈尔斯博士建议利用步态变异来确定一种评估指标，用于外周疾病患者的临床决策。在项目 2 中，Mukherjee 博士将研究提供自我运动感知的虚拟现实模拟是否会影响中风幸存者的步态变异。这项研究将确定增强视觉输入是否有助于消除门康复过程中常见的感觉冲突。在项目3中，乔博士将探讨与恒定视觉刺激和随机视觉刺激相比，在可变视觉刺激下行走时，有跌倒风险的老年人是否会表现出步态变异性的改善，接近健康年轻人的步态变异性。将研究三种刺激对步态变异性和自适应步态任务表现的短期和长期影响。在项目 4 中，Kyvelidou 博士将调查正常发育的婴儿和有自闭症风险的婴儿在第一年的姿势摇摆变化和凝视行为方面是否存在差异，以及它们与晚期诊断的关系。这些信息可以帮助开发自闭症的早期检测范例，并推进基础知识的发展，从而开发自闭症的治疗方法。为初级研究人员建立了强有力的指导计划，使他们能够取得成功的独立职业生涯。该中心以人类运动变异性研究的现有专业知识为基础，并利用一座新的专用建筑和最先进的实验室，展示了强大的机构支持。这种 COBRE 将通过新项目和研究人员的增加而得以延续。其结果将是一个持续的、自我维持的、有竞争力的研究中心，它将改变研究文化并激发 UNO 和整个内布拉斯加州的卓越表现。 公共卫生相关性：人体运动变异性作为重要临床信息的来源在很大程度上被忽视，并被视为运动系统中的噪音和错误。然而，在各种运动相关疾病中越来越多地发现人类运动变异性的改变，表明神经肌肉系统的适应能力降低。该中心的科学家将确定基于恢复运动的可变性和复杂性的最佳治疗方法，这些方法可应用于一系列疾病