Harnessing Movement Variability to Treat and Prevent Motor Related Disorder

利用运动变异性来治疗和预防运动相关疾病

• 批准号: 9057582
• 负责人: NIKOLAOS STERGIOU
• 金额: $ 205.21万
• 依托单位: UNIVERSITY OF NEBRASKA OMAHA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9057582
• 关键词: Autistic Disorder; Behavior; Centers of Research Excellence; Clinical; Clinical Investigator; Conflict (Psychology); Development; Diagnosis; Disease; Early Diagnosis; Elderly; Faculty; Gait; Human; Infant; Knowledge; Laboratories; Lead; Long-Term Effects; Mentors; Motion; Motor; Movement; Nebraska; Noise; Patients; Performance; Peripheral; Rehabilitation therapy; Research; Research Infrastructure; Research Personnel; Research Project Grants; Risk; Scientist; Self Perception; Sensory; Source; Stimulus; System; Universities; Visual; Walking; base; career; clinical decision-making; fall risk; gaze; member; neuromuscular system; prevent; programs; restoration; senior faculty; simulation; stroke survivor; virtual reality; visual stimulus

We propose to establish a center of biomedical research excellence at the University of Nebraska Omaha that will create the infrastructure and expertise base to explore the mechanisms of human movement variability in order to treat and prevent motor related disorders. This proposal involves four research projects, each lead by a junior faculty member who will be mentored by at least one senior faculty member who is an established clinical investigator. In Project 1, Dr. Myers proposes to identify an assessment metric for clinical decision making in patients with peripheral disease using gait variability. In Project 2, Dr. Mukherjee will investigate if Virtual Reality simulations providing perception of self-motion influence gait variability in stroke survivors. This research will identify if augmented visual inputs can help to remove sensory conflicts that commonly exist during gat rehabilitation. In Project 3, Dr. Qiao will explore if older adults who are at risk of falls will demonstrate improvements in gait variability that approach that of healthy young when walking with a variable visual stimulus, compared to an invariant visual stimulus and a random visual stimulus. The short and long-term effects of the three stimuli on gait variability and performance of adaptive gait tasks will be investigated. In Project 4, Dr. Kyvelidou will investigate if differences exist between typically developing infants and infants at risk for autism in terms of developing postural sway variability and gaze behavior in the first year as well as their relationship to later presence of diagnosis. This information could allow the development of an early detection paradigm for autism and the advancement of foundational knowledge from which treatments for autism may be developed. A strong mentoring program is established for the junior investigators, enabling them to achieve successful independent careers. This Center builds on existing expertise on the study of human movement variability and utilizes a new dedicated building with state-of-the-art laboratories demonstrating strong institutional support. This COBRE will be perpetuated by the addition of new projects and investigators. The result will be a continuing, self-sustaining, and competitive research Center that will transform the research culture and stimulate excellence in UNO and throughout Nebraska.

我们提议在内布拉斯加大学奥马哈分校建立一个生物医学研究卓越中心 这将创建基础设施和专业知识基础来探索人类运动的机制 变异性以治疗和预防运动相关疾病。该提案涉及四个研究项目， 每个项目均由一名初级教职人员领导，该教职人员将受到至少一名高级教职人员的指导，该高级教职人员是 成立临床研究者。在项目 1 中，迈尔斯博士建议确定临床评估指标 利用步态变异性为患有外周疾病的患者做出决策。在项目 2 中，Mukherjee 博士将 研究提供自我运动感知的虚拟现实模拟是否会影响中风的步态变异 幸存者。这项研究将确定增强视觉输入是否有助于消除感官冲突 通常存在于 gat 康复期间。在项目 3 中，乔博士将探讨是否存在以下风险的老年人： 跌倒将显示步态变异性的改善，接近健康年轻人行走时的步态变异性 与不变视觉刺激和随机视觉刺激相比，可变视觉刺激。短的 三种刺激对步态变异性和自适应步态任务表现的长期影响将是 调查了。在项目 4 中，Kyvelidou 博士将调查典型发育之间是否存在差异 婴儿和处于自闭症风险的婴儿在发展姿势摇摆变化和凝视行为方面 第一年以及它们与后来诊断的关系。这些信息可以让 开发自闭症早期检测范式和基础知识的进步 从中可以开发出自闭症的治疗方法。为初级学生制定了强有力的指导计划 调查员，使他们能够取得成功的独立职业生涯。该中心建立在现有 拥有研究人类运动变异性的专业知识，并利用拥有最先进设施的新专用建筑 实验室展示了强有力的机构支持。该 COBRE 将通过添加以下内容而得以延续： 新项目和研究人员。结果将是一项持续的、自我维持的、有竞争力的研究 该中心将改变 UNO 和整个内布拉斯加州的研究文化并激励卓越。