Claude D. Pepper Older Americans Independence Centers (OAICs)(P30)

克劳德·D·佩珀美国老年人独立中心 (OAIC)(P30)

• 批准号: 10026914
• 负责人: RAYMOND L YUNG
• 金额: $ 134.77万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10026914
• 关键词: Academy; Activities of Daily Living; Address; Aging; American; Basic Science; Biomechanics; Biostatistics Core; Capsicum; Caring; Chronic Disease; Clinical; Clinical Research; Clinical and Translational Science Awards; Cognition; Communities; Core Facility; Data; Development; Disease; Elderly; Elements; Environment; Epidemiology; Faculty; Funding; Future; Geriatrics; Geroscience; Goals; Grant; Health; Health Professional; Health Promotion; Home environment; Human; Impairment; Inflammation; Inflammatory; Infrastructure; Injury; Institute of Medicine (U.S.); Institutes; Knowledge; Laboratories; Leadership; Link; Longevity; Mediator of activation protein; Medicine; Mentorship; Metabolic; Metabolic Diseases; Methodology; Methods; Michigan; Modeling; Mus; Outcome; Participant; Physical Function; Physical activity; Pilot Projects; Population; Process; Ptosis; Quality of life; Recording of previous events; Reporting; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Rodent; Strategic Planning; Structure; Testing; Training; Training Activity; Training Programs; Translating; Translational Research; Translations; United States National Institutes of Health; Universities; Urinary Incontinence; Work; age related; aged; base; career development; clinical care; clinical investigation; cognitive function; cohesion; comorbidity; design; disability; education research; falls; functional independence; functional status; healthspan; human disease; human subject; improved; improved outcome; innovation; insight; interest; investigator training; member; mortality; prevent; programs; ranpirnase; research study; senior faculty

Abstract In this competitive renewal application, the University of Michigan Claude D. Pepper Older Americans Independence Center (UM Pepper Center), established in 1989, seeks to provide scientific leadership and innovation for aging research to address the central hypothesis that targeting metabolic and inflammatory factors as critical mediators of geriatric conditions and outcomes improves physical and cognitive functions of older adults. The overarching goal of the UM Pepper Center is to create, enhance and maintain a cohesive intellectual, technological, and administrative environment to maximize geriatrics research that will promote health and functional independence in older adults. The UM Pepper Center will pursue its objectives in five Aims. Aim 1) To support research that addresses the Center’s focus to improve understanding of how metabolic factors and inflammation determine key health outcomes related to mobility and functional status. Aim 2) To support translational research on the interaction of metabolic factors and inflammation with age-related diseases and comorbidities to improve health outcomes related to mobility and functional status. To achieve the aim, the UM Pepper Center will work closely with other UM programs including the Michigan Institute for Clinical and Health Research (MICHR), the home of the UM’s Clinical and Translational Science Award (CTSA). Aim 3) To provide Resource Cores that support and assist investigator-initiated projects related to the UM Pepper Center’s research focus. Aim 4) Through its Research Education Core (REC), to strengthen the UM environment for training of future academic leaders in geriatrics and aging who can conduct research related to the UM Pepper Center’s research focus. Aim 5) Through its Pilot and Exploratory Studies Core (PESC), to attract UM faculty to develop new research projects related to the UM Pepper Center’s research focus. The UM Pepper Center has in place a well-established leadership and administrative structure, a REC, a PESC, and four RCs: the Human Subjects and Assessment Core (HSAC); the Biomechanics Core (BC); the Design, Data and Biostatistics Core (DDBC); and the Core Facility for Aged Rodents (CFAR). The REC features three central elements: 1) a competitive program to select 2 promising UM junior faculty per year to conduct research relevant to the UM Pepper Center’s research and guarantee 50% effort for research career development; 2) a nationally recognized research training program for junior faculty engaged in such research, and 3) a Mentorship Program that enhances opportunities for junior faculty members to work closely with one or more UM senior investigators. The PESC will fund 5 or more pilot projects per year by leveraging OAIC funding with multiple other UM institutional resources. The RC’s will support multiple externally funded projects, the Pepper Center pilot grants and REC junior faculty, and continue to develop and test new methods to be used in Pepper Center research.

抽象的 在此竞争性更新申请中，密歇根大学Claude D. Pepper老年人 独立中心（UM胡椒中心）成立于1989年，试图提供科学领导和 衰老研究的创新，以解决靶向代谢和炎症的中心假设 作为老年疾病和结果的关键介体的因素，可以提高物理和认知功能 老年人。 UM胡椒中心的总体目标是创建，增强和维持一个凝聚力的知识分子， 技术和行政环境，以最大化老年医学研究，这将促进健康和 老年人的功能独立性。 UM胡椒中心将以五个目标追求其目标。目标1） 支持研究中心重点的研究，以提高对代谢因素和如何的理解 炎症决定了与移动性和功能状况有关的关键健康结果。目标2）支持 关于代谢因素与炎症与年龄相关疾病的相互作用的转化研究 合并症以改善与移动性和功能状况相关的健康结果。为了实现目标， 胡椒中心将与其他UM计划紧密合作，包括密歇根州临床与健康研究所 UM临床和转化科学奖（CTSA）的故乡Research（MICHR）。目标3） 提供资源核心，以支持和协助调查员发动的与UM Pepper相关的项目 中心的研究重点。目标4）通过其研究教育核心（REC），以加强UM 可以培训老年医学和衰老的未来学术领导者的环境，他们可以进行与 UM胡椒中心的研究重点。目标5）通过其试点和探索性研究核心（PESC），到达 吸引UM教师开发与UM Pepper中心研究重点有关的新研究项目。 UM Pepper中心已经建立了完善的领导和行政结构，A Rec，A PESC和四个RCS：人类受试者和评估核心（HSAC）；生物力学核心（BC）；这 设计，数据和生物统计学核心（DDBC）；以及老年啮齿动物（CFAR）的核心设施。 rec 具有三个中心元素：1）一项竞争计划，每年选择2个有希望的UM初级教师 进行与UM Pepper中心的研究相关的研究，并保证研究职业的50％的努力 发展; 2）针对从事此类研究的初级教师的全国认可的研究培训计划， 3）一项指导计划，为初级教职员工提供与一个人紧密合作的机会 或更多UM高级调查员。 PESC每年通过利用OAIC来资助5个或更多的试点项目 资助其他多个UM机构资源。 RC将支持多个外部资助的项目， 胡椒中心飞行员赠款和rec少年教师，并继续开发和测试新方法 用于胡椒中心研究。