PILOT AND EXPLORATORY STUDIES CORE

试点和探索性研究核心

• 批准号: 7802710
• 负责人: RAYMOND L YUNG
• 金额: $ 25.83万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7802710
• 关键词: Age; Aging; Aging-Related Process; Alcohol consumption; American; Animal Model; Applications Grants; Area; Award; Biological Factors; Chemistry; Comorbidity; Dependence; Discipline; Disease; Elderly; Environment; Ethnic group; Experimental Models; Extramural Activities; Factor Analysis; Faculty; Funding; Future; Gender; Genetic; Genetic Markers; Geriatrics; Gerontology; Goals; Grant; Group Identifications; Guidelines; Health; Health Services Research; Human; Impairment; Individual; Institution; Insulin; Investigation; Life; Manuscripts; Mentorship; Michigan; Mus; Muscle; Mutant Strains Mice; Pattern; Peer Review; Phenotype; Physiology; Pilot Projects; Population; Publishing; Research; Research Personnel; Research Project Grants; Research Proposals; Research Support; Resources; Risk; Rodent; Science; Scientific Evaluation; Series; System; Testing; Training and Infrastructure; Universities; Work; age related; behavioral health; blood glucose regulation; bone; career development; design; falls; flexibility; frailty; genetic analysis; improved; in vitro Model; insulin sensitivity; member; mouse model; programs; ranpirnase; research and development; research study; response; social; symposium; therapy design; tool

The goal of the Pilot and Exploratory Studies Core (PESC) is to provide support for studies that will develop and test new research ideas of high relevance to the Center's overall theme, the predictors and modulators of the aging phenotype and the ways in which genetic, environmental, and social factors influence late life disease through effects on the aging process. The PESC will thus fund pilot research studies over a wide range of disciplines, ranging from basic genetics and physiology through behavioral and health services research. Each submitted proposal will first receive an evaluation for scientific merit by at least two external reviewers, and then be further evaluated by OAIC leaders for its relevance to Center objectives. The Pepper Center's former Research Development Core (REIC) has made 61 pilot grant awards since its inception in 1989, mostly to junior faculty members, many of whom have now established themselves as productive independent researchers in geriatric medicine and cognate disciplines. Four projects have been selected for funding in the 2004 - 2005 academic year, including studies of (a) the genetics of bone chemistry and fragility; (b) a new system for investigation of insulin sensitivity using muscle explants; (c) factors modifying risk of falls in frail and healthy elderly subjects; and (d) the influences of gender and ethnic group on trajectories of alcohol consumption. The PESC will be directed by Dr. Richard Miller, who has served as director of the OAIC's RDC since 1993, and will be co-directed by Dr. Jeffrey Halter. Drs. Miller and Halter will work closely with the Directors of the RCDC to assist RCDC junior faculty as they develop plans for competitive Pilot Grant applications for PESC consideration.

试点和探索性研究核心 (PESC) 的目标是为将开发的研究提供支持 并测试与中心的总体主题、预测因素和调节因素高度相关的新研究思路 衰老表型以及遗传、环境和社会因素影响晚年的方式 通过影响衰老过程而产生疾病。因此，PESC 将资助广泛的试点研究 学科范围广泛，从基础遗传学和生理学到行为和健康服务 研究。每个提交的提案将首先接受至少两名外部机构的科学价值评估 审稿人，然后由 OAIC 领导进一步评估其与中心目标的相关性。胡椒 该中心的前研究开发核心 (REIC) 自 2017 年成立以来已颁发了 61 项试点资助 1989 年，主要针对初级教员，其中许多人现已成为富有成效的人 老年医学和相关学科的独立研究人员。四个项目已入选 2004-2005学年的资助，包括(a)骨化学遗传学和 脆弱性； (b) 使用肌肉外植体研究胰岛素敏感性的新系统； (c) 改变因素 体弱和健康的老年受试者跌倒的风险； (d) 性别和种族群体对 酒精消费轨迹。 PESC 将由 Richard Miller 博士领导，他曾担任 自 1993 年起担任 OAIC 的 RDC 主任，并由 Jeffrey Halter 博士共同领导。博士。米勒和霍尔特 将与 RCDC 的董事密切合作，协助 RCDC 初级教师制定以下计划： 供 PESC 考虑的竞争性试点拨款申请。