PILOT AND EXPLORATORY STUDIES CORE

试点和探索性研究核心

• 批准号: 7802710
• 负责人: RAYMOND L YUNG
• 金额: $ 25.83万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7802710
• 关键词: Age; Aging; Aging-Related Process; Alcohol consumption; American; Animal Model; Applications Grants; Area; Award; Biological Factors; Chemistry; Comorbidity; Dependence; Discipline; Disease; Elderly; Environment; Ethnic group; Experimental Models; Extramural Activities; Factor Analysis; Faculty; Funding; Future; Gender; Genetic; Genetic Markers; Geriatrics; Gerontology; Goals; Grant; Group Identifications; Guidelines; Health; Health Services Research; Human; Impairment; Individual; Institution; Insulin; Investigation; Life; Manuscripts; Mentorship; Michigan; Mus; Muscle; Mutant Strains Mice; Pattern; Peer Review; Phenotype; Physiology; Pilot Projects; Population; Publishing; Research; Research Personnel; Research Project Grants; Research Proposals; Research Support; Resources; Risk; Rodent; Science; Scientific Evaluation; Series; System; Testing; Training and Infrastructure; Universities; Work; age related; behavioral health; blood glucose regulation; bone; career development; design; falls; flexibility; frailty; genetic analysis; improved; in vitro Model; insulin sensitivity; member; mouse model; programs; ranpirnase; research and development; research study; response; social; symposium; therapy design; tool

The goal of the Pilot and Exploratory Studies Core (PESC) is to provide support for studies that will develop and test new research ideas of high relevance to the Center's overall theme, the predictors and modulators of the aging phenotype and the ways in which genetic, environmental, and social factors influence late life disease through effects on the aging process. The PESC will thus fund pilot research studies over a wide range of disciplines, ranging from basic genetics and physiology through behavioral and health services research. Each submitted proposal will first receive an evaluation for scientific merit by at least two external reviewers, and then be further evaluated by OAIC leaders for its relevance to Center objectives. The Pepper Center's former Research Development Core (REIC) has made 61 pilot grant awards since its inception in 1989, mostly to junior faculty members, many of whom have now established themselves as productive independent researchers in geriatric medicine and cognate disciplines. Four projects have been selected for funding in the 2004 - 2005 academic year, including studies of (a) the genetics of bone chemistry and fragility; (b) a new system for investigation of insulin sensitivity using muscle explants; (c) factors modifying risk of falls in frail and healthy elderly subjects; and (d) the influences of gender and ethnic group on trajectories of alcohol consumption. The PESC will be directed by Dr. Richard Miller, who has served as director of the OAIC's RDC since 1993, and will be co-directed by Dr. Jeffrey Halter. Drs. Miller and Halter will work closely with the Directors of the RCDC to assist RCDC junior faculty as they develop plans for competitive Pilot Grant applications for PESC consideration.

试点和探索性研究核心（PESC）的目标是为将发展的研究提供支持 并测试与中心总体主题高度相关的新研究思想，预测因素和调节符 衰老表型以及遗传，环境和社会因素影响晚期生活的方式 通过对衰老过程的影响疾病。因此，PESC将基于广泛的试点研究资助 从基本遗传学和生理学到行为和卫生服务的学科范围 研究。每个提交的提案将首先获得至少两个外部的科学价值评估 审稿人，然后由OAIC领导者进一步评估其与中心目标的相关性。胡椒 自成立以来，中心的前研究开发核心（REIC）已获得了61个飞行员赠款奖 1989年，主要是针对初级教师，其中许多人现在已经确立了自己的生产力 老年医学和同源学科的独立研究人员。已经选择了四个项目 2004年至2005年学年的资金，包括（a）骨化遗传学和 脆弱性； （b）使用肌肉外植体研究胰岛素敏感性的新系统； （c）修改因素 脆弱和健康的老年受试者跌倒的风险； （d）性别和族裔对 饮酒的轨迹。 PESC将由理查德·米勒（Richard Miller）博士执导，他曾担任 自1993年以来，OAIC的RDC主任将由Jeffrey Halter博士共同执导。博士。米勒和吊带 将与RCDC的董事紧密合作，以协助RCDC初级教师制定计划 PESC考虑的竞争性试点赠款申请。