Claude D. Pepper Older Americans Independence Centers (OAICs)(P30)

克劳德·D·佩珀美国老年人独立中心 (OAIC)(P30)

• 批准号: 9095187
• 负责人: RAYMOND L YUNG
• 金额: $ 90.53万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9095187
• 关键词: ARHGEF5 gene; Activities of Daily Living; Aging; American; Animals; Award; Basic Science; Biomechanics; Capsicum; Caring; Chronic; Clinical; Clinical Sciences; Communities; Comorbidity; Core Facility; Data Analyses; Development; Disease; Elderly; Elements; Environment; Epidemiology; Faculty; Funding; Future; Geriatrics; Gerontology; Goals; Guidelines; Health; Health Professional; Home environment; Human; Impairment; Inflammation; Inflammation Mediators; Injury; Institute of Medicine (U.S.); Institutes; Intervention; Knowledge; Leadership; Life; Link; Mentorship; Metabolic; Metabolic Diseases; Methodology; Methods; Michigan; Mission; Modeling; Mus; Outcome; Participant; Physical activity; Physicians; Pilot Projects; Population; Predisposition; Ptosis; Quality of life; Reporting; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Rodent; Strategic Planning; Structure; Testing; Training; Training Activity; Training Programs; Translating; Translational Research; Translations; United States National Institutes of Health; Universities; Urinary Incontinence; Work; age related; aged; base; career development; clinical care; clinical investigation; data management; disability; falls; functional status; human disease; human subject; improved; innovation; insight; investigator training; meetings; member; next generation; operation; prevent; programs; ranpirnase; research study; senior faculty

DESCRIPTION (provided by applicant): This is a competing renewal application for the Claude D. Pepper Older Americans Independence Center at the University of Michigan (UM Pepper Center). The specific aims of the UM Pepper Center is: 1) to support research that will improve understanding of how metabolic factors and inflammation interact with age related diseases and comorbidities to determine key health outcomes related to mobility and functional status. 2) To support translational research on the interaction of metabolic factors and inflammation with age-related diseases and comorbidities to improve health outcomes related to mobility and functional status. To achieve this aim, the UM Pepper Center will work closely with other UM programs including the NIH funded Michigan Institute for Clinical and Health Research (MICHR), the home of the UM's Clinical and Translational Science Award (CTSA). 3) To provide Resource Cores that support and assist investigator-initiated projects related to the UM Pepper Center's research focus. 4) Through its Research Career Development Core (RCDC), to strengthen the UM environment for training of future academic leaders in geriatrics and aging who can conduct research related to the UM Pepper Center's research focus. 5) Through its Pilot and Exploratory Studies Core (PESC), to attract UM junior faculty, as well as selected senior faculty not previously involved in aging research, to develop new research projects related to the UM Pepper Center's research focus. The UM Pepper Center, now in its 25th year of continuous NIA funding, has in place a well-established leadership and administrative structure, an RCDC, a PESC, and four RCs: the Human Subjects and Assessment Core (HSAC); the Biomechanics Core (BC); the Methodology, Data Management and Analysis Core (MDMAC); and the Core Facility for Aged Rodents(CFAR). The RCDC features three central elements: 1) a competitive program to select 2 promising UM junior faculty per year to conduct research relevant to the UM Pepper Center's research focus using the KL2mechanism to guarantee 75% effort for research career development; 2) a nationally recognized research training program for junior faculty engaged in such research, and 3) a Mentorship Program that enhances opportunities for junior faculty members to work closely with one or more UM senior investigators. The PESC, through rigorous external review, will fund 4 or more pilot projects per year. The RC's will support multiple externally funded projects, the Pepper Center pilot grants and RCDC junior faculty, and continue to develop and test new methods to be used in Pepper Center research.

描述（由申请人提供）：这是密歇根大学（UM Pepper Center）的Claude D. Peper D. Peper D. Peper D. Peper D. Peper D. Peper D. Peper D. Peper D. Peper D. Peper D. Peper D. UM胡椒中心的具体目的是：1）支持研究，以提高对代谢因素和炎症与年龄相关疾病和合并症如何相互作用的理解，以确定与流动性和功能状况有关的关键健康结果。 2）支持有关代谢因素与与年龄相关疾病和合并症的炎症相互作用的转化研究，以改善与流动性和功能状况有关的健康结果。为了实现这一目标，UM胡椒中心将与其他UM计划紧密合作，包括NIH资助的密歇根州临床和健康研究所（MICHR），该研究所是UM临床和转化科学奖（CTSA）的所在地。 3）提供资源核心，以支持和协助与UM Pepper中心的研究重点相关的研究人员发动的项目。 4）通过其研究职业发展核心（RCDC），以增强UM环境，以培训老年医学和衰老的未来学术领导者，他们可以进行与UM Pepper中心的研究重点有关的研究。 5）通过其试点和探索性研究核心（PESC），吸引了UM初级教师，以及以前从未参与过衰老研究的精选高级教师，以开发与UM Pepper中心的研究重点相关的新研究项目。 UM Pepper Center已在连续的NIA资助第25年，已经建立了完善的领导力和行政结构，RCDC，A PESC和四个RCS：人类对象和评估核心（HSAC）；生物力学核心（BC）；方法，数据管理和分析核心（MDMAC）；以及老年啮齿动物（CFAR）的核心设施。 RCDC具有三个中心要素：1）一项竞争计划，每年选择2个有前途的UM初级教师，以使用KL2 Mechanics进行与UM Pepper中心的研究重点相关的研究，以确保75％的研究努力进行研究职业发展； 2）一项针对从事此类研究的初级教师的全国认可的研究培训计划，以及3）指导计划，为初级教职员工与一名或多个UM高级调查员紧密合作的机会增加了机会。 PESC通过严格的外部审查将为每年4个或更多的试点项目提供资金。 RC将支持多个由外部资助的项目，Pepper Center Pilot Grants和RCDC初级教师，并继续开发和测试用于Pepper Center Research中的新方法。