Remote STATE training for Insomnia in Older Adults

针对老年人失眠的远程 STATE 培训

基本信息

批准号：
10693814
负责人：
Thomas VanVleet
金额：
$ 46.74万
依托单位：
POSIT SCIENCE CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10693814
关键词：
Academy Acetylcholine Activities of Daily Living Address Adopted Adult Age American Attention Behavior Therapy California Chronic Insomnia Clinic Clinical Cognition Cognitive Cognitive deficits Collaborations Data Dependence Devices Dimensions Disease remission Elderly Electroencephalography Exhibits Functional disorder Goals Head Health Imaging ligands Impaired cognition Inadequate Sleep Hygiene International Internet Intervention Judgment Maintenance Measures Medial Medical Device Medicine Memory Mental Depression Moods Neurologic Neuronal Plasticity Neuropsychology Neurotransmitters Outcome Patients Persons Pharmaceutical Preparations Pharmacological Treatment Phase Pilot Projects Polysomnography Positron-Emission Tomography Prosencephalon Protocols documentation Public Health Quality of life Randomized, Controlled Trials Research Risk San Francisco Sleep Sleep Deprivation Sleeplessness Societies Staging System Therapeutic Thinking Time Training Training Programs Translations Universities Vulnerable Populations active control active control group aging population alertness brain health clinically significant cognitive control cognitive function cognitive training comparative efficacy computerized cost design directed attention economic cost efficacy evaluation executive function fall risk follow up assessment functional independence healthy aging human old age (65+)improved improvement on sleep indexing member mortality neural neuroregulation novel poor sleep prevent primary outcome processing speed programs rumination secondary outcome skill acquisition sleep behavior sleep onset sleep quality sleep regulation success sustained attention tool

项目摘要

PROJECT SUMMARY The goal of the current Phase II project is definitively evaluate the efficacy of a computerized cognitive training program (rSTATE) designed to improve sleep regulation and brain health and extend functional independence in older adults with insomnia. Nearly half of all adults over age sixty suffer disruptions in sleep that increase as a function of age. Nearly one third meet criteria for chronic insomnia, resulting in poor quality of life and increased risk of depression. Notably, cognitive decline in older adults with insomnia exceeds that observed in normal healthy aging. In addition to the obvious health and quality-of-life ramifications of late life insomnia, there are high economic costs. Thus, implementing scalable interventions to prevent functional dependence and cognitive impairment is of critical importance to overall public health. Here, we propose to evaluate a novel intervention that improve sleep, cognitive deficits and bolster functional abilities in patients with insomnia. Our preliminary data is among the first evidence to demonstrate that a neuroplasticity-based intervention has ‘real-world’ benefits and the potential to be a highly-scalable form of computerized cognitive training for providing protection against insomnia. At the completion of this project we will have outcomes data sufficient to support a compelling submission to the FDA for clearance as a medical device indicated for the treatment of insomnia.

项目摘要当前II阶段项目的目的是确定评估了计算机认知培训的效率计划（RSTATE）旨在改善睡眠调节和大脑健康，并扩展功能独立性在失眠的老年人中。六十岁以上的所有成年人中，近一半的睡眠中断，随着年龄的影响而增加。将近一个第三符合慢性失眠的标准，导致生活质量差和抑郁症的风险增加。值得注意的是，失眠的老年人的认知能力下降超出了正常健康衰老中观察到的。在除了后期失眠的明显健康和生活质量后果，还有很高的经济费用。那是实施可扩展干预措施以防止功能依赖和认知障碍对整体公共卫生至关重要。在这里，我们建议评估一种新的干预措施，以改善睡眠，认知定义并增强功能失眠患者的能力。我们的初步数据是第一个证明A 基于神经可塑性的干预措施具有“现实世界”的好处，并且有可能成为高度估计的形式计算机化认知培训，以防止失眠。该项目完成时，我们将拥有足以支持令人信服的提交的结果数据清除作为医疗装置的FDA表示治疗失眠。