Amplified Attention Training (AAT) for Age-related Cognitive Decline

针对与年龄相关的认知衰退的增强注意力训练 (AAT)

基本信息

批准号：
8868870
负责人：
Thomas VanVleet
金额：
$ 50.52万
依托单位：
POSIT SCIENCE CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-06-15 至 2017-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8868870
关键词：
Activities of Daily Living Aftercare Age-associated memory impairment Aging Attention Auditory Behavior Therapy Code Cognition Computer software Data Discrimination Effectiveness Elderly Evaluation Exercise Feedback Goals ICD-9 Independent Living Individual Internet Iowa Learning Managed Care Marketing Measures Medical Device Memory Minor Modeling Modification Monitor Neuropsychology Outcome Participant Performance Phase Physicians Population Psychiatry Psychologist Publishing Quality of life Randomized Controlled Clinical Trials Randomized Controlled Trials Research Personnel Rewards Site Specificity Stimulus Time Training Training Programs United States Food and Drug Administration Universities Validation alternative treatment base clinically significant cognitive control cognitive enhancement cognitive function cognitive training computerized cost effective design effective therapy executive function experience functional outcomes improved interest medical schools multi-site trial normal aging novel novel strategies outcome forecast phase 1 study phase I trial primary outcome programs prototype public health relevance standard of care standardize measure sustained attention trial design

项目摘要

DESCRIPTION (provided by applicant): The goal of the current project is to revise a prototype of a computerized attention training program (Memory Lane-Amplified Attention Training, M-AAT) designed for age-related cognitive decline completed in Phase I, and conduct a multi-site, randomized, controlled trial to establish efficacy in this population. As a group, individuals with age-related cognitive decline tend to have poorer long-term prognosis and are more likely to require managed care than individuals without similar declines. Our recent studies are among the first to demonstrate that M-AAT, targeting sustained attention and cognitive control, can produce lasting benefits. The overall goal of the current project is to measure 3 co-primary outcomes: attention, executive function and functional capacity. Evidence from our Phase I trial shows that M-AAT can improve attention and executive function. At the completion of this project we will have outcomes data sufficient for submission to the FDA for clearance as a medical device indicated for cognitive enhancement in age-related cognitive decline (ICD-9 Code R41.81).

描述（由申请人提供）：当前项目的目的是修改计算机注意力训练计划的原型（记忆巷放大注意力训练，M-AAT），旨在在第一阶段完成的与年龄相关的认知下降，并进行多站点，随机，随机，对照试验以在该人群中建立功效。作为一个小组，与没有类似下降的人相比，与年龄相关的认知下降往往具有较差的长期预后，并且更有可能需要管理护理。我们最近的研究是第一个证明M-AAT以持续关注和认知控制的目标可以产生持久的好处。当前项目的总体目标是衡量3个共同成果：注意力，执行功能和功能能力。我们I阶段试验的证据表明，M-AAT可以提高注意力和执行功能。该项目完成后，我们将拥有足够的结果数据，足以提交FDA以进行清除，作为一种医疗设备，指示与年龄相关的认知下降（ICD-9代码R41.81）的认知增强。