Irradiation and Animal Core

辐射和动物核心

基本信息

批准号：
10025390
负责人：
Marjan Boerma
金额：
$ 25.84万
依托单位：
UNIV OF ARKANSAS FOR MED SCIS
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-06-24 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10025390
关键词：
Advertising Animal Husbandry Animal Model Animals Area Arkansas Behavioral Behavioral Assay Biological Breeding Budgets Calibration Cancer Biology Cell Culture Techniques Centers of Research Excellence Chemotherapy and/or radiation Collaborations Communication Complex Core Facility Data Analyses Development Discipline Dose-Rate Early Diagnosis Ensure Equipment Experimental Models Faculty Fee Schedules Fee-for-Service Plans Foundations Future Gamma Rays Generations Goals Human Resources IACUC Immune response Infrastructure Institutes Institution Laboratories Learning Maintenance Mentors Methods Modeling Musculoskeletal Diseases Normal tissue morphology Phase Pilot Projects Preparation Procedures Radiation Radiation Injuries Radiation therapy Radiobiology Radiometry Reporting Reproducibility Research Research Infrastructure Research Personnel Research Project Grants Research Support Resolution Resource Development Roentgen Rays Scheme Science Services Surveys System Talents Toxic effect Training Transgenic Animals Translational Research Treatment-Related Cancer Ultrasonography Universities Validation animal breeding cancer therapy career design experience image guided improved in vivo innovation instrumentation irradiation member model design pre-clinical prevent recruit research facility side effect therapy design web site

项目摘要

PROJECT SUMMARY/ABSTRACT Translational research into the biology of cancer therapy side effects relies heavily on complex in vivo research models that require specific expertise for their design, development, implementation, and troubleshooting. New investigators frequently experience startup problems when their research requires the use of these models. The primary objective of the Irradiation and Animal Core (Core C) is to facilitate the development and use of pre-clinical animal models and radiobiological principles by investigators in the Center for Studies of Host Response to Cancer Therapy and other COBRE Centers on campus. The secondary objective is to develop the core into a self-sustaining facility that contributes to the overall research infrastructure of the institution. During Phase 1 of the project, the core built a strong infrastructure for radiation research, high- resolution ultrasound imaging of small animals, and animal breeding and handling procedures. Radiation and ultrasound services also were made available as a fee-for-service to all investigators from our institution and others in the region. During Phase 2, the core will build on this foundation to provide project leaders and pilot project grantees with resources for the development and maintenance of animal and radiation models (Aim 1), to provide mentoring and training for early-stage investigators in animal husbandry and radiation biology (Aim 2), and to develop the core into a self-sustaining facility that improves the research infrastructure on campus (Aim 3). The core will advise on and assist with the generation of transgenic animal models, the navigation of the Institutional Animal Care and Use Committee, the implementation of optimal animal breeding schemes and other animal husbandry issues, and the use of high-resolution ultrasound imaging. Additionally, the core maintains 5 state-of-the-art experimental X-ray and γ-ray facilities. Core personnel confirm that the necessary maintenance, calibration, and radiation dosimetry are performed to guarantee high-quality radiation services, and they provide expert advice in radiobiological matters, assist Center investigators in developing appropriate radiation models for their research, and assist them in the use of the irradiators. Core services advertising, fee schedule maintenance, and budget report preparation will continue and will be optimized if necessary. Regular surveys among core users will identify additional services that may be required, and with COBRE and institutional support, such services will be developed. The services provided by Core C will impact the Center's research by assisting Center investigators in the design and development of their research models and offer learning experiences that will enhance their professional development into independent researchers in the area of cancer therapy side effects. Moreover, the core will enrich the research infrastructure for established investigators.

项目摘要/摘要癌症治疗副作用生物学的翻译研究依赖于体内复杂需要特定专业知识的研究模型，以设计，开发，隐含和故障排除。新调查人员经常遇到启动问题这些模型。中心研究人员的发展前动物模型和放射生物学原理的发展用于宿主对癌症治疗和校园中的其他毛茸茸中心的研究目的是将核心发展成一个自我维持的设施，该设施有助于整体研究基础设施该研究所的研究所，核心建立了强大的基础设施，以进行辐射研究分辨率的小动物的超声成像以及动物繁殖和处理程序超声服务也可以作为收费服务提供给我们研究所的所有调查人员，该地区的其他人。具有用于开发和维护动物和辐射模型的资源的项目授予者（AIM 1），为畜牧业和放射生物学的早期研究人员提供指导和培训（目标 2），并将核心发展成自我维持的设施，校园的研究基础设施（目标3）。 Institute Animal Care和使用委员会，隐含动物育种学校其他畜牧业问题，以及高分辨率的超声成像维护5个最先进的实验X射线和γ射线设施。进行维护，校准和辐射剂量法以保证高质量的辐射服务，他们提供放射生物学事务方面的专家建议，协助中心调查人员开发适当的核心服务广告，FEEE，核心服务广告。常规。核心用户之间的调查将需要的IDITAL服务服务，并使用毛病和机构支持，将开发此类服务。协助中心研究人员的研究模型设计和开发并提供学习可以增强其专业发展到癌症领域的独立研究人员的经验此外，治疗副作用。