Modernization of Small Animal Caging for infectious disease studies at the Boise VAMC

博伊西 VAMC 用于传染病研究的小动物笼舍现代化

基本信息

批准号：
10734738
负责人：
Jay R Radke
金额：
$ 21.39万
依托单位：
IDAHO VETERANS RESEARCH / EDUCATION FDN
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10734738
关键词：
2019-nCoV Air Movements Animal Experiments Animal Husbandry Animal Model Animals Award Beds COVID-19 pandemic Cell Nucleus Clinical Communicable Diseases DNA sequencing Development Emerging Communicable Diseases Exposure to Fostering Frequencies Funding Generations Goals Hamsters Housing Human Resources Humidity Idaho Immune response Infectious Agent Laboratories Medical Medical center Modernization Mus Names Pilot Projects Reproducibility Research Research Personnel Research Project Grants Research Support Safety Scientist Site Small Business Technology Transfer Research Temperature Time Training United States Department of Veterans Affairs United States National Institutes of Health Water Water consumption animal dander biobank biological research career clinical diagnostics diagnostic assay experimental study improved innovation microorganism growth molecular diagnostics novel therapeutics pandemic disease programs research study variant detection ventilation wasting

项目摘要

PROJECT SUMMARY While static caging for husbandry of small animals is accepted by the Guide, ventilated caging has become the gold standard for small animal husbandry. Static caging results in increased temperature and humidity in the cages. This results in wet bedding materials that can foster growth of micro-organisms. As a result, increased changing of animal bedding is required to maintain sanitary living conditions. Increased frequency in cage changing has multiple detrimental effects. First, more bedding is required to house the animals and generates more bedding waste. Second, multiple cage changes per week increases the water consumption and dirty wastewater generation as cages require sanitization in hot water cage washers. Third, increased handling of animals can have negative effects on research studies. Fourth, frequent cage changing increases the exposures of VMU personnel to both animal dander and infectious agents. The goal of this project is to obtain funds to upgrade the caging at the Boise Veterans Affairs Medical Center Veterinary Medical Unit (VMU) from static caging to ventilated caging. By moving from static caging to ventilated caging the animals will be in housing that provides better air flow allowing for better control of temperature and humidity in their cages, improving not only the living conditions for the small animals but increasing the rigor and reproducibility of the experiments conducted in the VMU as well as safety of VMU personnel.

项目摘要指南接受了小动物饲养的静态笼子，但通风的笼子已经成为小型畜牧业的黄金标准。静态笼导致温度升高，并且笼子里的湿度。这会产生湿的床上用品，可以促进微生物的生长。作为结果，需要增加动物床上用品以维持卫生生活条件。增加笼子变化的频率具有多种有害效应。首先，需要更多的床上用品来容纳动物并产生更多的床上用品浪费。其次，每周多个笼子变化增加了用水量随着笼子需要在热水笼垫圈中进行消毒，脏废水会产生肮脏的废水。第三，增加对动物的处理可能会对研究产生负面影响。第四，频繁的笼子变化增加 VMU人员对动物皮屑和传染性药物的暴露。该项目的目标是获得资金从Boise退伍军人事务医疗中心兽医医疗部（VMU）升级笼子静态的笼子与通风式笼子。通过从静态笼中移动到通风的笼子，动物将在外壳中这提供了更好的空气流，从而可以更好地控制笼子中的温度和湿度，从而改善只有小动物的生活条件，但增加了实验的严格性和可重复性在VMU和VMU人员的安全中进行。