Smart, wearable artificial lung system

智能、可穿戴式人工肺系统

基本信息

批准号：
10558842
负责人：
Joseph Allen Potkay
金额：
$ 72.35万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-06-01 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10558842
关键词：
Acute Affect Age Air Air Movements Alkalosis American Anesthesia procedures Animal Model Animal Testing Animals Blood Carbon Dioxide Cattle Cessation of life Chest Chronic Chronic Obstructive Pulmonary Disease Clinical Compensation Computer software Development Devices Disease Dysbarism Dyspnea Engineering Etiology Excision Extracorporeal Circulation Future Gases Goals Hip region structure Home Hour Human Hypocapnia In Vitro Injury Life Lung Lung Transplantation Lung diseases Mechanical ventilation Metabolic Methods Mind Monitor Patients Performance Physical Rehabilitation Physical therapy Physiology Population Prosthesis Pump Quality of life Recording of previous events Recovery Rehabilitation therapy Research Respiratory Failure Rest Risk System Technology Testing Transplantation United States National Institutes of Health Ventilator Volutrauma Waiting Lists Water artificial lung awake comorbidity design exhaust first-in-human healing improved in vivo innovation laptop lung injury miniaturize miniaturized device operation portability prototype pulmonary function respiratory sensor sheep model technology development wearable device

项目摘要

ABSTRACT Tens of thousands of Americans with end stage lung disease (ESLD) are not candidates for lung transplant and thus are doomed to suffer a long and miserable death from dyspnea, limitation of activity, and eventually total respiratory failure. The long-term goal of this technology-development project is to improve the quality of life of end stage lung disease (ELSD) patients by developing wearable artificial lungs that compensate for the changing metabolic needs of the patient. The objectives of the current proposal are to: 1) develop the smart, wearable artificial lung system; and, 2) evaluate the wearable artificial lung system in acute and chronic animal models. At the completion of this project, we will have a functioning wearable artificial lung system that adjusts CO2 clearance based on patient needs, thereby enabling large changes in patient activity and disease status during rehabilitation and daily life. We will be ready to perform extended animal tests and apply for an IDE for first in human trials.

抽象的成千上万的患有末期肺部疾病（ESLD）的美国人不是肺移植和因此，注定要遭受呼吸困难，活动限制以及最终总计死亡的长期死亡呼吸衰竭。这个技术发展项目的长期目标是改善生活质量末期肺疾病（ELSD）患者通过开发可穿戴的人造肺来补偿变化患者的代谢需求。当前建议的目标是：1）开发智能，可穿戴的人工肺系统； 2）评估急性和慢性动物模型中的可穿戴人造肺系统。在该项目的完成，我们将拥有一个可穿戴的可穿戴人造肺系统，可调整CO2 根据患者需求的清除率，从而在患者活动和疾病状态发生巨大变化康复和日常生活。我们将准备进行扩展的动物测试，并首先申请IDE 人类试验。