Automated control of artificial lung systems to meet patient metabolic needs

自动控制人工肺系统以满足患者代谢需求

• 批准号: 10663779
• 负责人: Joseph Allen Potkay
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-11-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10663779
• 关键词: Acute; Affect; Age; Air Movements; Alkalosis; American; Animal Model; Animal Testing; Animals; Blast Injuries; Blood; Carbon Dioxide; Cattle; Cessation of life; Chronic; Chronic Obstructive Pulmonary Disease; Computer software; Development; Devices; Diagnosis; Disease; Dysbarism; Dyspnea; Electronics; Engineering; Etiology; Excision; Exercise; Extracorporeal Circulation; Gases; Goals; Gulf War; Health; Healthcare Systems; Hour; Human; Hypocapnia; In Vitro; Injury; Life; Lung; Lung Transplantation; Lung diseases; Mechanical ventilation; Membrane; Metabolic; Methods; Monitor; Patients; Performance; Physical Rehabilitation; Physical therapy; Physiology; Population; Prosthesis; Pump; Quality of life; Recording of previous events; Recovery; Rehabilitation therapy; Reporting; Research; Respiratory Failure; Respiratory System; Rest; Risk; Services; Surveys; System; Technology; Testing; Time; Transplantation; Ventilator; Veterans; Volutrauma; Waiting Lists; Water; Work; artificial lung; awake; base; comorbidity; cost; design; disability; exhaust; experience; first-in-human; healing; improved; in vivo; innovation; laptop; lung basal segment; lung injury; meter; military veteran; operation; programs; prototype; pulmonary function; respiratory; sensor; sheep model; smoke inhalation; technology development

Tens of thousands of Americans and Veterans with end stage lung disease (ESLD) are not candidates for lung transplant and thus are doomed to suffer a long and miserable death from dyspnea, limitation of activity, and eventually total respiratory failure. The long-term goal of this technology-development project is to improve rehabilitation from lung disease by developing artificial lung systems that automatically and rapidly compensate for the changing respiratory and metabolic needs of the patient, thereby increasing patient health, comfort, activity, and ability to exercise and rehabilitate. The objectives of the current proposal are to: 1) develop a control system for an artificial lung system featuring sweep gas servoregulation to adjust CO2 removal based on patient need; and, 2) evaluate the control system in animal models. At the completion of this project, we expect to be ready to integrate the developed control system with various artificial lung systems and prostheses that will, for the first time, enable large changes in patient activity during rehabilitation and daily life.

数万名患有终末期肺病 (ESLD) 的美国人和退伍军人不适合接受肺病治疗 移植，因此注定会因呼吸困难、活动受限而遭受长期而悲惨的死亡 最终完全呼吸衰竭。该技术开发项目的长期目标是提高 通过开发自动、快速的人工肺系统来康复肺部疾病 补偿患者不断变化的呼吸和代谢需求，从而改善患者健康， 舒适度、活动性以及锻炼和康复的能力。当前提案的目标是：1) 开发用于人工肺系统的控制系统，具有扫气伺服调节功能以调节二氧化碳 根据患者需要去除； 2）评估动物模型中的控制系统。完成本次操作后 项目中，我们期望准备好将开发的控制系统与各种人工肺系统集成 和假肢将首次使患者在康复和日常活动中发生巨大变化 生活。