A Wearable CO2 Removal Device for Veteran Rehabilitation from Lung Disease

用于肺病退伍军人康复的可穿戴式二氧化碳去除装置

• 批准号: 10631937
• 负责人: Joseph Allen Potkay
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2023-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10631937
• 关键词: 3-Dimensional; 3D Print; Acute; Acute respiratory failure; Adult; Affect; Animal Testing; Animals; Anticoagulants; Blood; Blood flow; Blood specimen; Carbon Dioxide; Cardiac Output; Cattle; Cessation of life; Chronic; Chronic Obstructive Pulmonary Disease; Clinical; Clinical Trials; Closure by clamp; Computer Models; Computer-Aided Design; Data; Destinations; Device Designs; Device Removal; Devices; Drops; Excision; Exhalation; Experimental Designs; Fiber; Gases; General Population; Goals; Healthcare; Healthcare Systems; Heart; Human; Hypercapnia; Hypoventilation; Individual; Inhalation; Lead; Length; Liquid substance; Lung; Lung diseases; Measurement; Measures; Methods; Modeling; Monitor; Patients; Performance; Porosity; Pump; Quality of life; Rehabilitation therapy; Resistance; Sheep; System; Testing; Time; Transplantation; Venous; Ventilator; Veterans; Work; artificial lung; base; cost; design; disability; experimental study; improved; improved outcome; lung basal segment; lung pressure; novel; palliative; portability; pressure; prototype; sheep model; simulation; ventilation; wearable sensor technology

Veterans are three times more likely than the general population to develop chronic obstructive pulmonary disease (COPD), the fourth leading cause of US death. Current therapies are principally palliative, and have limited ability to restore Veterans to a sustained better quality of life. The goal of this work is to improving Veteran rehabilitation from lung disease by developing a novel artificial lung (AL) device which is optimized for CO2 removal. Recently, we developed an AL design based on concentric gating which improves overall device efficiency compared to current clinical devices. In this work, we will optimize this design to develop a CO2 removal artificial lung (CORAL) which is suitable for incorporation into a wearable system. In Aim 1, a 3D computer model of the CORAL will be built using Solidworks and blood flow simulations will be performed using the Solidworks Flow Simulation add-in. A porous media model will be used to model flow resistance due to the fiber bundle. Blood flow simulations within devices having varied fiber lengths and fiber bundle porosities will be performed. The simulations will be used to guide design of an optimized device that meets all stated specifications for the CORAL device. Once the design is chosen, components will be 3D printed and used for prototype fabrication. In Aim 2, CORAL devices will be fabricated and bench tested to experimentally determine pressure drop and gas exchange performance. In Aim 3, CORAL devices which meet gas exchange and pressure specification will be tested using an acute sheep model of hypercapnia. The successful completion of these aims will lead to a Merit Review application that will focus on the long-term implementation of the developed CO2 removal device. These studies will include chronic sheep experimentation and incorporation into an automated, wearable system, and will provide the information necessary to plan human clinical trials.

退伍军人发展慢性阻塞性的可能性是一般人群的三倍 肺疾病（COPD），这是美国死亡的第四个主要原因。当前的疗法是 主要是姑息性的，并且能够将退伍军人恢复到持续更高质量的能力有限 生活。这项工作的目的是通过发展来改善肺部疾病的退伍军人康复 一种用于二氧化碳去除的新型人工肺（AL）装置。最近，我们开发了 基于同心门的Al设计，该设计提高了整体设备效率与 当前的临床设备。在这项工作中，我们将优化该设计以开发二氧化碳去除人造 肺（珊瑚），适合掺入可穿戴系统中。在AIM 1中，一台3D计算机 将使用实心制造珊瑚模型，并将进行血流模拟 使用SolidWorks流量模拟加载项。多孔媒体模型将用于建模 由于纤维束引起的电阻。纤维变化的设备中的血流模拟 将执行长度和纤维束孔隙率。模拟将用于指导设计 符合珊瑚装置的所有既定规格的优化设备。一旦设计 选择，组件将被打印并用于原型制造。在AIM 2中，珊瑚 设备将被制造并测试，以实验确定压降和气体 交换性能。在AIM 3中，满足气体交换和压力的珊瑚装置 规格将使用急性绵羊高碳酸酯模型进行测试。成功 这些目标的完成将导致优点审查申请，该申请将集中于长期 实施开发的二氧化碳去除设备。这些研究将包括慢性绵羊 实验并掺入自动化系统中，并将提供 计划人类临床试验所需的信息。