Alcohol use, physical activity, and neurophysiological indicators of behavioral adaptability

饮酒、体力活动和行为适应性的神经生理学指标

• 批准号: 10609697
• 负责人: Andrew Antonio Ude
• 金额: $ 4.77万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10609697
• 关键词: Acute; Address; Adult; Affect; Age; Alcohol abuse; Alcohol consumption; Alcohols; Back; Baroreflex; Behavior; Behavior Control; Behavior assessment; Behavioral; Biological; Blood Pressure; Brain; Cardiovascular system; Chronic; Communication; Cross-Sectional Studies; Development; Electrocardiogram; Electroencephalography; Event-Related Potentials; Exercise; Exhibits; Foundations; Future; Goals; Health; Health behavior; Heart; Heart Rate; Incentives; Individual; Individual Differences; Informal Social Control; Intervention; Interview; Intoxication; Knowledge; Longevity; Measures; Methodology; Monitor; Motivation; National Institute on Alcohol Abuse and Alcoholism; Neural Pathways; Neurosciences; Parents; Patient Self-Report; Pattern; Periodicity; Persons; Physical activity; Process; Regulation; Research; Resources; Rest; Science; Stimulus; Strategic Planning; Testing; Training; United States National Institutes of Health; Withdrawal; actigraphy; addiction; alcohol cue; alcohol effect; alcohol measurement; alcohol research; alcohol use disorder; binge drinker; binge drinking; chronic alcohol ingestion; college; critical period; cue reactivity; design; drinking; emerging adult; emerging adulthood; experimental study; hazardous drinking; heart rate variability; high risk; high risk drinking; improved; incentive salience; neural; neuromechanism; neurophysiology; population health; programs; recruit; skills; social determinants; timeline; young adult

Project Summary and Abstract Health behaviors established during emerging adulthood often portend life-long behavior patterns. During this developmental stage, high-risk alcohol use behavior (binge-drinking) increases, while levels of physical activity begin to decrease. When considered individually, alcohol use and physical activity have marked and opposing influences on neurophysiological indicators of health and self-regulation. Acute and chronic alcohol negatively impact the cardiovascular system, resulting in decreased heart rate variability (HRV) and baroreflex sensitivity. High-risk drinking is also associated with greater incentive salience of alcohol cues, resulting in an enhanced P3 event-related potential to alcohol related stimuli (ACR-P3). Increased physical activity improves HRV, baroreflex sensitivity, and neural processes central to P3 amplitude reduction, although ACR-P3 has not been examined. Paradoxically, greater alcohol consumption consistently has been associated with more frequent physical activity across the adult lifespan. This raises the question of how the effects of this antagonistic clustering of co-occurring health-related behaviors accrue on the cardiovascular and neural processes that underlie their regulation. Further, a few recent studies suggest that this between-person association observed between alcohol use and physical activity may not reflect within-person drinking-activity relations, and most studies have relied on self-reports of physical activity. The goal of this study is to measure covariation in alcohol use and physical activity, assessed retrospectively, as well as objectively over a 7-10 day period to test the cumulative effects of drinking and activity behaviors on HRV, baroreflex sensitivity, and ACR-P3. The proposed research and training plan leverages the resources of a NIAAA-supported experiment (R21AA029604) examining whether a brief behavioral manipulation of the baroreflex loop can alter neural reactivity to alcohol cues in emerging adult binge drinkers. The proposed study will use simultaneously collected cardiovascular (ECG) and neural (EEG) measures recorded at rest and during an alcohol-cue reactivity paradigm from two sessions of the parent study, separated by 7-10 days. It will add on objective monitoring of physical activity during the intersession interval, combined with a time-line follow back interview of alcohol use and physical activity during the interval. Aim 1 is to examine covariation of alcohol use and physical activity behaviors assessed by self-report and actigraphy. Aim 2 is to examine the total effects of alcohol use and physical activity behaviors between sessions on HRV and baroreflex sensitivity (0.1Hz HRV). Aim 3 is to examine the cumulative effects of alcohol use and physical activity between sessions on incentive motivation towards alcohol cues, indicated by the ACR-P3. The proposed research and training plan are designed to address current gaps in understanding between drinking and activity behaviors to neurophysiological indicators of self-regulation, while providing the applicant with deeper knowledge and skills in alcohol research to support a developing research program on integrated cardiovascular and neural mechanisms in alcohol and co-occurring health behaviors.

项目摘要和摘要 在成年期间建立的健康行为通常会预示着终身行为模式。在此期间 发育阶段，高风险的酒精使用行为（暴饮暴食）增加，而体育锻炼水平 开始减少。当单独考虑时，饮酒和体育锻炼已经标记和相反 对健康和自我调节的神经生理学指标的影响。急性和慢性酒精负面 影响心血管系统，导致心率变异性降低（HRV）和压力反射灵敏度。 高风险饮酒还与酒精提示的更大激励性显着性有关，从而增强了P3 与酒精相关刺激的事件相关的潜力（ACR-P3）。体育锻炼增加可改善HRV，BaroreFlex 敏感性和神经过程降低了P3振幅的中心，尽管尚未检查ACR-P3。 矛盾的是，更多的饮酒始终与更频繁的体育锻炼有关 整个成人寿命。这就提出了一个问题，即这种拮抗聚类的效果如何同时出现 与健康相关的行为对构成其监管的心血管和神经过程产生。更远， 最近的一些研究表明，饮酒与物理之间观察到这种人际关系的关联 活动可能无法反映出人际关系关系，大多数研究都依赖于 体育锻炼。这项研究的目的是评估酒精使用和体育锻炼的协方差 回顾性以及在7-10天的客观上进行客观的测试，以测试饮酒和活动的累积影响 HRV，BaroreFlex灵敏度和ACR-P3的行为。拟议的研究和培训计划利用了 NIAAA支持的实验的资源（R21AA029604）检查是否短暂的行为操纵 在新兴的成人暴饮暴食者中，巴罗雷福利循环可以改变对酒精提示的神经反应性。提议 研究将同时收集的心血管（ECG）和神经（脑电图）措施在静止和 在来自父母研究的两个课程中的酒精提示反应性范式中，分别为7-10天。会 在间隔间隔期间对体育活动的客观监控，结合时间表。 在此间隔期间，饮酒和体育锻炼的背面访谈。目标1是检查酒精的协变 通过自我报告和动作法评估的使用和体育活动行为。目标2是检查总效果 HRV和Baroreflex敏感性之间的饮酒和体育活动行为（0.1Hz HRV）。 AIM 3是检查酒精使用和会议之间的体育锻炼对激励的累积影响 ACR-P3指示的酒精提示动机。拟议的研究和培训计划的设计 解决饮酒和活动行为与神经生理指标之间的理解差距 自我调节，同时为申请人提供酒精研究中的更深入的知识和技能，以支持 开发有关酒精和同时发生的综合心血管和神经机制的研究计划 健康行为。