Integrative Pathways to Health and Illness

健康与疾病的综合途径

• 批准号: 10004314
• 负责人: CAROL D. RYFF
• 金额: $ 11.92万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-25 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10004314
• 关键词: Adult; Affect; African American; Age; Aging; Amygdaloid structure; Archives; Attention; Base of the Brain; Biological; Biological Markers; Cardiovascular system; Cities; Cognitive; Communities; Data; Data Collection; Disease; Distant; Drops; Elderly; Endowment; Environment; Environmental Risk Factor; Functional Magnetic Resonance Imaging; Funding; Funding Opportunities; Gene Expression; Genes; Genetic; Health; Immune; Incentives; Inflammatory; Inflammatory Response; Interview; Investigation; Knowledge; Life; Link; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Methods; Mind; Mission; Morbidity - disease rate; Musculoskeletal; Neurobiology; Neurosciences; Neurosecretory Systems; Participant; Pathway interactions; Personal Satisfaction; Persons; Physiological; Prevention; Principal Investigator; Process; Productivity; Program Research Project Grants; Psychosocial Factor; Publications; Recurrence; Regulation; Research; Resources; Respondent; Risk Factors; Sampling; Stress; Structure; Surveys; System; Techniques; Thick; Time; Time Study; Twin Multiple Birth; United States; Update; Variant; Work; affective neuroscience; age related; aged; base; biopsychosocial; cognitive capacity; cognitive function; computerized; design; diaries; emotion regulation; experience; follow-up; forging; hippocampal morphometry; middle age; mortality; neurobiological mechanism; novel; psychologic; psychosocial; public health relevance; recruit; resilience; response; social; sociodemographics; socioeconomics; statistics; white matter

ABSTRACT - Overall This revised application is in response to the U19 funding opportunity for the Midlife in the United States (MIDUS) study. The mission of MIDUS is to study health, broadly defined, as an integrated biopsychosocial process that unfolds across the decades of adult life. The baseline study was begun in 1995 with over 7,000 adults, including twins, aged 25 to 74. This sample has been followed for 20 years, and along the way, MIDUS was augmented with city-specific sample of African Americans, and more recently, a newly recruited national sample, known as the MIDUS Refresher. Using a multi-project design, comprehensive survey, biomedical, and neuroscience data have been collected on MIDUS respondents. In addition, current P01 funding of MIDUS has facilitated the completion of a 3rd wave of survey data and 2nd wave of cognitive data. We seek funds in this application to collect longitudinal data for the Daily Diary Project, the Biomarker Project, and the Neuroscience Project. We also request funds to initiate a new Gene Expression Project focused on the expression of genes central to the body's immune-inflammatory response as well as a Retention-Early Warning Project, designed to reinstate a portion of drop-outs from prior waves of data collection. These five projects are supported by an Administrative Core, a Bio Core, and a Statistics Core. Across all projects and cores, detailed responses have been assembled in response to concerns raised in the prior review. In addition, the Overall Plan documents the enormous momentum that has grown up around the MIDUS study via updates on data usage and scientific productivity, including the high volume of new publications (88) generated just since this application was first submitted ten months ago. MIDUS fills a unique niche among NIA-supported longitudinal studies, given its wide age expanse and its unusual depth in psychosocial, biomarker, and neuroscience assessments, which permit a focus on the neurobiological mechanisms and pathways through which sociodemographic and psychosocial factors influence unfolding profiles of health and illness. A unique strength is the thematic focus on psychosocial strengths, which are being used to explicate profiles of resilience in many adults confronted with varieties of adversity. MIDUS also includes a national twin sample, thus offering unique opportunities to advance knowledge of the interplay of genetic and environmental factors in understanding healthy or unhealthy aging. Importantly, MIDUS has captured the attention of the scientific community: it is the most frequently downloaded study at the National Archive of Computerized Data on Aging (NACDA). Nearly 700 publications have been generated, many breaking new ground in forging linkages among sociodemographic, psychosocial, and neurobiological factors to account for differing pathways to later life morbidity and mortality.

摘要 - 总体 此修订后的申请是为了响应美国中年 U19 资助机会 （MIDUS）研究。 MIDUS 的使命是研究广义上的健康，将其作为综合的生物心理社会学 贯穿成人生活数十年的过程。基线研究于 1995 年开始，涉及 7,000 多人 成年人，包括双胞胎，年龄 25 至 74 岁。这个样本已经被跟踪了 20 年，一路走来，MIDUS 增加了特定城市的非裔美国人样本，最近又增加了一个新招募的国家样本 示例，称为 MIDUS Refresher。采用多项目设计、综合调查、生物医学、 已收集了 MIDUS 受访者的神经科学数据。此外，目前的 P01 资金为 MIDUS协助完成了第三波调查数据和第二波认知数据。我们寻求 本申请中的资金用于收集每日日记项目、生物标记项目和 神经科学项目。我们还请求资金启动一个新的基因表达项目，重点关注 对身体免疫炎症反应以及早期保留至关重要的基因的表达 警告项目，旨在恢复之前几波数据收集中的部分退出。这五个 项目由管理核心、生物核心和统计核心支持。跨所有项目和 针对先前审查中提出的关切，已汇总了详细答复。在 此外，总体计划通过以下方式记录了围绕 MIDUS 研究产生的巨大势头 数据使用和科学生产力的最新情况，包括产生的大量新出版物（88） 自从十个月前首次提交该申请以来。 MIDUS 在 NIA 支持的纵向研究中占据了独特的地位，因为它的年龄范围广泛且 在心理社会、生物标志物和神经科学评估方面具有不同寻常的深度，这使得我们可以重点关注 社会人口学和心理社会因素影响的神经生物学机制和途径 影响健康和疾病的发展概况。一个独特的优势是对心理社会的主题关注 优势，这些优势被用来解释许多成年人面对各种困难时的复原力概况 逆境。 MIDUS 还包括全国双胞胎样本，从而提供了独特的晋升机会 了解遗传和环境因素相互作用的知识，以了解健康或不健康的衰老。 重要的是，MIDUS 引起了科学界的关注：它是最常见的 在国家老龄化计算机化数据档案馆 (NACDA) 下载研究。近700种出版物 已经产生了许多在建立社会人口、心理社会、 和神经生物学因素来解释晚年发病率和死亡率的不同途径。