Project 2 -- MIDUS Daily Diary Project

项目2——MIDUS日记项目

• 批准号: 10707327
• 负责人: CAROL D. RYFF
• 金额: $ 75.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-25 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10707327
• 关键词: Address; Adult; Affect; Age; Alzheimer' s disease related dementia; Behavioral; Biological; Biological Markers; Black race; Brain; COVID-19; Characteristics; Cognitive; Collection; Complex; Data; Data Collection; Dementia; Diurnal Rhythm; Economic Recession; Economics; Elderly; Emotional; Epigenetic Process; Frequencies; Future; Gene Expression; Genomics; Health; Health Status; Hydrocortisone; Impaired cognition; Impairment; Inflammation; Inflammatory; Life Cycle Stages; Link; Long-Term Effects; Measurement; Measures; Mental Health; Neurosciences; Neurosecretory Systems; Outcome; Participant; Pathway interactions; Patient Self-Report; Pattern; Performance; Personal Satisfaction; Personality; Persons; Physiological; Process; Protocols documentation; Psychosocial Factor; Publications; Recovery; Regulation; Retirement; Role; Saliva; Salivary; Social Change; Stress; Surveys; Tablet Computer; Tablets; Technology; Telephone; Testing; Time; Uncertainty; Widowhood; Work; allostatic load; cardiovascular risk factor; caregiving; cognitive performance; design; diaries; experience; follow-up; functional disability; health disparity; human old age (65+); individual variation; innovation; middle age; physical conditioning; physical symptom; racial disparity; racial prejudice; smartphone based assessment; sociodemographic factors; sociodemographics; stressor

ABSTRACT – DAILY DIARY PROJECT The objective of the MIDUS Daily Project is to determine how short term fluctuations in daily stress processes impact longer-term health and well-being throughout midlife and later adulthood. Specific aims are to: (1) Assess changes in multiple aspects of daily stressors and daily well-being across up to four occasions spanning up to 30 years and three historic periods; (2) Investigate how disrupted diurnal rhythms of salivary cortisol provide a physiological mechanism linking daily stress and health; and (3) Add tablet-based mobile assessments of daily experiences to the MIDUS protocol to enhance daily measurements of stress processes and capture unique assessments of cognitive health. These aims will be addressed by conducting additional waves of longitudinal data collection for the MIDUS Core and Refresher Daily projects. We will continue to use an 8-day telephone diary study of daily stressors and well-being combined with multiple assessments of saliva (4 occasions × 4 days) to obtain salivary cortisol. In addition, we will add a 14-day tablet data collection following the daily telephone survey. The MIDUS Daily project will continue to incorporate the rich sociodemographic, personality, and cognitive measures from other MIDUS projects in our analyses to study how they relate to changes in daily stress processes over up to 30 years. We will also use data from the gene expression, biomarker, and neuroscience projects to examine how changes in daily stress processes predict gene expression profiles and changes in various indicators of health (e.g., allostatic load, inflammatory processes, neuroendocrine regulation, cardiovascular risk).

摘要——每日日记项目 MIDUS 每日项目的目标是确定每日压力过程中的短期波动如何 影响整个中年和成年后期的长期健康和福祉，具体目标是：(1) 评估最多四种情况下日常压力源和日常幸福感的多个方面的变化 跨越长达 30 年和三个历史时期；（2）研究唾液的昼夜节律是如何被扰乱的； 皮质醇提供了一种将日常压力与健康联系起来的生理机制；(3) 添加基于平板电脑的移动设备； 根据 MIDUS 协议评估日常经验，以增强压力过程的日常测量 并获取对认知健康的独特评估。这些目标将通过进行额外的工作来实现。 我们将继续使用 MIDUS Core 和 Refresher Daily 项目的纵向数据收集波。 对日常压力源和健康状况进行为期 8 天的电话日记研究，并结合唾液的多项评估 （4次×4天）获取唾液皮质醇此外，我们将添加14天的平板电脑数据收集。 继每日电话调查之后，MIDUS Daily 项目将继续纳入富人。 我们分析研究中来自其他 MIDUS 项目的社会人口统计学、个性和认知测量 它们与长达 30 年的日常压力过程的变化有何关系我们还将使用来自基因的数据。 表达、生物标志物和神经科学项目，以研究日常压力过程的变化如何预测 基因表达谱和各种健康指标的变化（例如，稳态负荷、炎症 过程、神经内分泌调节、心血管风险）。