Project 4 -- MIDUS Genomics Project

项目4——MIDUS基因组项目

基本信息

批准号：
10707335
负责人：
CAROL D. RYFF
金额：
$ 56.91万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-25 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10707335
关键词：
Acceleration Affect Age Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia American Biological Biological Aging Biological Markers Biological Process Biology Blood specimen Buffers Cognitive aging Communities Cross-Sectional Studies DNA DNA Methylation Data Data Collection Disadvantaged Elements Epigenetic Process Funding Gene Expression Genes Genetic Genetic Polymorphism Genetic Transcription Genomics Genotype Health Human Individual Individual Differences Inflammatory Leukocytes Life Link Longitudinal Studies Measures Mediating Mediator Methodology Molecular Outcome Participant Pathway interactions Pattern Personal Satisfaction Personality Character Process Psychosocial Factor Psychosocial Influences RNA RNA methylation Research Research Personnel Resources Risk Risk Assessment Risk Factors Role Sampling Single Nucleotide Polymorphism Social support Stress Time Training Twin Multiple Birth Venous blood sampling Viral Viral Genes Well in self analytical tool biopsychosocial cohort design disorder risk functional genomics genetic information genetic risk factor genetic variant genome resource genome-wide genomic data middle age mortality risk optimism polygenic risk score population health psychologic psychosocial rate of change resilience resilience factor response social socioeconomics targeted biomarker transcriptome

项目摘要

ABSTRACT – GENOMICS PROJECT The MIDUS Genomics Project provides genomic data resources, analytic tools, and methodological training to advance the overall MIDUS objective of defining the relationship between psychosocial factors and health- and aging-related outcomes. Resources provided by this project include: 1) twin-based research strategies to identify overall genetic influences on psychosocial and health outcomes; 2) genome-wide RNA profiles to identify the specific gene expression pathways that mediate these influences; 3) genome-wide DNA methylation profiles to identify the specific epigenetic pathways that mediate these influences; 4) genome-wide single-nucleotide polymorphism profiles to identify the role of specific genetic polymorphisms and polygenic risk profiles; 5) targeted genotyping of specific gene variants of particular relevance to MIDUS research objectives, such as the APOE gene associated with Alzheimer’s Disease; and 6) training to MIDUS investigators in the special substantive and analytic aspects of genomic data. Genomic measures are collected from approximately 1200 participants in the MIDUS Biomarker Project (Core MIDUS and MIDUS Refresher samples), and include 2 waves of RNA and DNA methylation profiles that can quantify rates of biological aging and change over time in inflammatory biology and antiviral biology. Aims of the MIDUS Genomics Project include: Aim 1: Collect and disseminate RNA gene expression profiles, DNA methylation profiles, and targeted genotyping data; Aim 2: Analyze the relationship between psychosocial risk processes (e.g., socio-economic and socio-relational disadvantage) and resilience processes (e.g., psychological well- being and social resources), and longitudinal rates of change in the “Conserved Transcriptional Response to Adversity” (CTRA) RNA profile and DNA methylation measures of “epigenetic age” and mortality risk; Aim 3: Define the relationship between CTRA gene expression and epigenetic age acceleration to determine their correlation and respective relationships to health, well-being, and disease risk. The genomic data provided by this project provide essential genetic and molecular elements of MIDUS’s overall integrative biopsychosocial characterization of health and well-being of mid-life Americans.

摘要——基因组学项目 MIDUS 基因组学项目提供基因组数据资源、分析工具和方法培训推进 MIDUS 的总体目标，即定义心理社会因素与健康和健康之间的关系该项目提供的资源包括：1）基于双胞胎的研究策略确定对社会心理和健康结果的总体遗传影响；2) 全基因组 RNA 谱 3）全基因组DNA 4) 全基因组甲基化谱，以确定介导这些影响的特定表观遗传途径；单核苷酸多态性谱以确定特定遗传多态性和多基因的作用 5) 与 MIDUS 研究特别相关的特定基因变体的靶向基因分型目标，例如与阿尔茨海默病相关的 APOE 基因；以及 6) MIDUS 培训；基因组数据的特殊实质性和分析方面的研究人员是。从 MIDUS 生物标志物项目（核心 MIDUS 和 MIDUS 复习样本），并包括 2 波 RNA 和 DNA 甲基化谱，可以量化 MIDUS 的目标是炎症生物学和抗病毒生物学的生物衰老和随时间的变化。基因组学项目包括：目标 1：收集和传播 RNA 基因表达谱、DNA 甲基化目标 2：分析社会心理风险过程之间的关系（例如，社会经济和社会关系劣势）和复原力过程（例如，心理健康）社会资源），以及“保守转录反应”的纵向变化率目标 3：定义 CTRA 基因表达与表观遗传年龄加速之间的关系，以确定其与健康、福祉和疾病风险的相关性和各自关系。该项目提供了 MIDUS 整体综合生物心理社会的基本遗传和分子元素中年美国人的健康和福祉特征。