A Low-Cost Wearable Connected Health Device for Monitoring Environmental Pollution Triggers of Asthma in Communities with Health Disparities

一种低成本可穿戴互联健康设备，用于监测健康差异社区中哮喘的环境污染诱因

• 批准号: 10601615
• 负责人: Krishna Naishadham
• 金额: $ 29.19万
• 依托单位: WI-SENSE, LLC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2024-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10601615
• 关键词: Address; Adult; Affect; African American; African American population; Age; Air; Air Pollutants; Air Pollution; American; Area; Asthma; Atmosphere; Bluetooth; Calibration; Cellular Phone; Chemicals; Chronic Obstructive Pulmonary Disease; Code; Collaborations; Color; Communities; Data; Detection; Devices; Diagnosis; Disease; Disparity population; Distant; Electronics; Elements; Environmental Exposure; Environmental Monitoring; Environmental Pollution; Ethnic Origin; Exhibits; Exposure to; Gases; Generations; Goals; Health; Health Care Costs; Healthcare Systems; Height; Heterogeneity; Housing; Humidity; Incidence; Industrialization; Institutional Racism; Intuition; Lab On A Chip; Laboratories; Measurement; Measures; Minority; Monitor; Morbidity - disease rate; Motor Vehicles; Nitrogen Dioxide; Outcome; Ozone; Participant; Particulate Matter; Patients; Persons; Phase; Physicians; Pilot Projects; Policies; Pollution; Population; Populations at Risk; Poverty; Public Health Schools; Race; Racial Segregation; Reaction Time; Reporting; Reproducibility; Research; Research Project Grants; Resistance; Respiratory Disease; Risk; Self Care; Self Management; Semiconductors; Signal Transduction; Site; Socioeconomic Status; Source; Spatial Distribution; Spirometry; Surface; Symptoms; Temperature; Testing; Time; Transportation; United States; Universities; Wrist; airway inflammation; asthma exacerbation; asthmatic patient; battery life; cohort; conditioning; connected health; cost; design; electronic sensor; empowerment; environmental monitoring device; fine particles; health disparity; improved; indexing; innovation; integrated circuit; metal oxide; metropolitan; microsensor; miniaturized sensor; mortality; patient home care; personal exposure monitor; pollutant; portability; power consumption; prototype; psychosocial stressors; pulmonary function; recruit; residential segregation; respiratory health; response; sensor; sensor technology; sex; signal processing; smartphone application; socioeconomics; volatile organic compound; wearable device; wearable sensor technology; wireless

Project Abstract Asthma affects 25 million Americans, and chronic obstructive pulmonary disease (COPD) affects 16 million, together costing 130 billion USD annually to the US healthcare system. Asthma is more prevalent in African American population (10.6%) than white population (7.7%). Poverty level has an impact as well, with twice as much asthma incidence in people below 100% of the poverty threshold as compared to people above 450% of the threshold. Racial-ethnic and socioeconomic health disparities in the US due to air pollution exposure are well documented and have persisted despite overall decreases in ozone and particulate matter pollution. This disproportionate exposure reflects generations of discriminatory practices including racially-segregated residential policies that result in communities of color being more frequently located near major sources of air pollution, both industrial and transportation-related. The proposed research project seeks to address health disparities related to air pollution by enabling self-monitoring of environmental triggers of asthma and other respiratory diseases, so that the patients are empowered for self-management of their disease. This study will develop and test a wearable sensor array with a small form-factor for monitoring personal exposure to several important air pollutants, and then pilot this device in a small panel of African-American adults with physiciandiagnosed asthma. The device will be sensitive to a variety of primary and secondary pollutants from both motorvehicle traffic and industrial emissions. It will employ metal oxide semiconductor sensors to measure ozone, nitrogen dioxide, and volatile organic compounds as well as relative humidity and ambient temperature. The device will be able to connect to Bluetooth-enabled smartphones for data logging and display purposes, yet it will be small enough to be worn on the wrist. We will validate the utility of this device for improving health by recruiting 20 African-American adults who live in the Atlanta area and have been diagnosed with asthma. These participants will use the device to monitor their air pollution exposure for one month. During this month, they will also measure their lung function twice per day using a small commercially-available spirometer that we will provide them. We will develop a smartphone application that will clearly display air quality data in an intuitive color-coded display. The app will also include lung function data from spirometry in a percent-predicted score relative to expected values based on age, height, sex and race. The overall goal of this project is to demonstrate the feasibility of a wearable device to assist in the identification of air pollution-related asthma triggers and to empower asthma patients to improve their health by reducing exposure.

项目摘要 哮喘影响2500万美国人，慢性阻塞性肺疾病（COPD）影响1600万， 美国医疗保健系统每年共同花费1300亿美元。哮喘在非洲人更为普遍 美国人口（10.6％）比白人人口（7.7％）。贫困水平也有影响，有两倍 与450％以上的人相比 阈值。由于空气污染的暴露，美国的种族族裔和社会经济健康差异很好 尽管臭氧和颗粒物污染总体上减少，但仍记录并持续存在。这 不成比例的暴露反映了几代歧视性实践，包括种族隔离 导致颜色社区更频繁地位于主要空气来源附近的住宅政策 污染，无论是工业和运输有关的。拟议的研究项目旨在解决健康 通过实现哮喘和其他环境触发的自我监控，与空气污染有关的差异 呼吸道疾病，使患者有权自我管理疾病。这项研究会 开发和测试带有小型因子的可穿戴传感器阵列，以监视个人接触几个 重要的空气污染物，然后在一个诊断为哮喘的医师的一小部分非裔美国人成年人面板中驾驶此装置。该设备将对来自汽车交通和工业排放的各种主要和次要污染物敏感。它将采用金属氧化物半导体传感器来测量臭氧， 二氧化氮和挥发性有机化合物以及相对湿度和环境温度。这 设备将能够连接到启用蓝牙的智能手机，以进行数据记录和显示目的，但是 将足够小，可以戴在手腕上。我们将验证该设备通过 招募20名居住在亚特兰大地区的非裔美国人成年人，并被诊断出患有哮喘。这些 参与者将使用该设备来监视其空气污染暴露一个月。在这个月中，他们将 还使用一个小型的市售肺活量计测量其每天两次肺功能 提供他们。我们将开发一个智能手机应用程序，该应用程序将在直觉中清楚地显示空气质量数据 颜色编码的显示。该应用程序还将以肺活量测定法以一个百分比的分数包括肺功能数据 相对于基于年龄，身高，性别和种族的预期价值。该项目的总体目标是证明 可穿戴设备的可行性，以帮助识别与空气污染有关的哮喘触发和 通过减少暴露量来赋予哮喘患者能够改善健康状况。