HMS/BCH Center for Neuroscience Research

HMS/BCH 神经科学研究中心

• 批准号: 10016380
• 负责人: Bernardo L Sabatini
• 金额: $ 47.5万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10016380
• 关键词: Address; Animals; Architecture; Area; Boston; Brain; Brain Diseases; Cells; Cellular Morphology; Center Core Grants; Chronic; Clinical; Collaborations; Communities; Complement; Core Facility; Custom; Development; Developmental Biology; Discipline; Drosophila genus; Electron Microscopy; Faculty; Fostering; Funding; Future; Gap Junctions; Genetic; Goals; Grant; Human; Image; Imaging Device; Imaging technology; Individual; Institution; Laboratories; Learning; Magnetic Resonance Imaging; Medical; Methods; Microscope; Mission; Modernization; National Institute of Neurological Disorders and Stroke; Nervous System Physiology; Nervous system structure; Neurobiology; Neurosciences; Neurosciences Research; Organelles; Pediatric Hospitals; Process; Quantitative Microscopy; Research; Research Personnel; Research Project Grants; Research Support; Resolution; Resources; Rodent; Services; Stress; Structure; Sustainable Development; Synapses; System; Technology; Time; Tissues; United States National Institutes of Health; anatomic imaging; base; cost effective; design; frontier; human disease; human model; imaging approach; imaging facilities; imaging modality; instrumentation; interest; medical schools; molecular imaging; nanometer; neural circuit; new technology; novel strategies; operation; programs; ranpirnase; success; tool

Abstract Modern neuroscience relies heavily on tools to visualize the structure, and at times the function, of the nervous system. This includes tools that examine structure at the level of few nanometers (electron microscopy) to those that examine whole human brain (MRI). Between these extremes are approaches to examine cellular sub-compartments and organelles, cellular morphology, small-scale circuit organization, and whole rodent or drosophila brains. Through the Institutional Center Core Grant to Support Neuroscience Research program, we established at Harvard Medical School and Boston Children's Hospital a Center Imaging Core that supports research in our community directed at understanding the structure and function of the nervous system in healthy animals and in models of human disease. The core has been operational for approximately 6 years, and has facilitated or directly made possible research projects throughout our community. The core operates both turnkey systems for daily use, specialized microscopes for chronic, high-content, and high-throughput imaging, as well as custom pipelines for imaging at the highest resolution in tissue and cells. The core has been successful, supporting over 35 NINDS projects across 27 laboratories. For the upcoming grant period, we have expanded the set of microscopes available and have reorganized and simplified the administrative and technical support structure to increase efficiency. Beyond its research mission, the Center will also continue to serve as a nexus for collaborative interactions across neuroscience communities and an educational hub for learning about imaging technologies and approaches. Through the sustained development of this Center, we hope to continue to provide cost-effective and productive services to NINDS researchers while further deepening ties between these two vibrant neuroscience communities.

抽象的 现代神经科学在很大程度上依赖于可视化结构的工具，有时是神经的功能 系统。这包括在少量纳米（电子显微镜）水平上检查结构的工具 那些检查整个人大脑的人（MRI）。在这些极端之间是检查细胞的方法 子室和细胞器，细胞形态，小规模电路组织以及整个啮齿动物或 果蝇大脑。通过机构中心核心赠款来支持神经科学研究计划， 我们在哈佛医学院和波士顿儿童医院建立了一个支持的中心成像核心 我们社区的研究致力于了解神经系统的结构和功能 健康动物和人类疾病模型。核心已经运作大约6年了， 并促进或直接制定了整个社区的研究项目。核心运行 两种用于日常使用的交钥匙系统，用于慢性，高态和高通量的专业显微镜 成像以及在组织和细胞中最高分辨率成像的定制管道。核心有 成功，为27个实验室的35多个NINDS项目提供了支持。对于即将到来的赠款期， 我们已经扩展了可用的显微镜​​集，并重新组织和简化了管理 和技术支持结构以提高效率。除了其研究任务之外，该中心还将 继续作为神经科学社区的协作互动的联系 用于学习成像技术和方法的教育枢纽。通过持续发展 在这个中心，我们希望继续为Ninds的研究人员提供具有成本效益和富有成效的服务 同时，这两个充满活力的神经科学社区之间的关系进一步加深了联系。

项目成果

Calcium-Dependent Protein Kinase C Is Not Required for Post-Tetanic Potentiation at the Hippocampal CA3 to CA1 Synapse.

海马 CA3 至 CA1 突触的强直后增强不需要钙依赖性蛋白激酶 C。

• DOI: 10.1523/jneurosci.0708-16.2016
• 发表时间: 2016
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Wang,Chih-Chieh;Weyrer,Christopher;Paturu,Mounica;Fioravante,Diasynou;Regehr,WadeG
• 通讯作者: Regehr,WadeG

An image-based RNAi screen identifies SH3BP1 as a key effector of Semaphorin 3E-PlexinD1 signaling.

• DOI: 10.1083/jcb.201309004
• 发表时间: 2014-05-26
• 期刊: The Journal of cell biology
• 作者: Tata A;Stoppel DC;Hong S;Ben-Zvi A;Xie T;Gu C
• 通讯作者: Gu C

Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic.

• DOI: 10.1038/s41467-021-22898-3
• 发表时间: 2021-05-11
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Zhang X;Luo M;Dastagir SR;Nixon M;Khamhoung A;Schmidt A;Lee A;Subbiah N;McLaughlin DC;Moore CL;Gribble M;Bayhi N;Amin V;Pepi R;Pawar S;Lyford TJ;Soman V;Mellen J;Carpenter CL;Turka LA;Wickham TJ;Chen TF
• 通讯作者: Chen TF

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells.

• DOI: 10.1038/nbt.4226
• 发表时间: 2018-10
• 期刊: NATURE BIOTECHNOLOGY
• 影响因子: 46.9
• 作者: Maoz, Ben M.;Herland, Anna;FitzGerald, Edward A.;Grevesse, Thomas;Vidoudez, Charles;Pacheco, Alan R.;Sheehy, Sean P.;Park, Tae-Eun;Dauth, Stephanie;Mannix, Robert;Budnik, Nikita;Shores, Kevin;Cho, Alexander;Nawroth, Janna C.;Segre, Daniel;Budnik, Bogdan;Ingber, Donald E.;Parker, Kevin Kit
• 通讯作者: Parker, Kevin Kit

Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo.

通过上调体内抗凋亡程序，保护微环境局部肿瘤细胞免受 HER2 靶向治疗的影响。

• DOI: 10.1038/s41523-017-0020-z
• 发表时间: 2017
• 期刊: NPJ breast cancer
• 影响因子: 5.9
• 作者: Zoeller,JasonJ;Bronson,RoderickT;Selfors,LauraM;Mills,GordonB;Brugge,JoanS
• 通讯作者: Brugge,JoanS