DENDRITIC CA SIGNALS IN STRIATAL MEDIUM SPINY NEURONS

纹状体中棘神经元中的树突 CA 信号

• 批准号: 8362499
• 负责人: Bernardo L Sabatini
• 金额: $ 2.11万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362499
• 关键词: Buffers; Calcium Channel; Cells; Corpus striatum structure; Coupled; Dendrites; Dendritic Spines; Dependence; Diffusion; Excitatory Synapse; Funding; Glutamate Receptor; Goals; Grant; Ions; Modeling; National Center for Research Resources; Neurons; Parents; Principal Investigator; Research; Research Infrastructure; Resources; Signal Transduction; Source; United States National Institutes of Health; Vertebral column; cost; hippocampal pyramidal neuron; virtual; voltage

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We would like to model a dendritic spine as an excitatory synapse, and its associated parent dendrite. Virtual Cell's ability to model ion flux in a voltage sensitive manner gives a powerful and unique framework to do so. The specific goal would be to model a physiologically accurate CA1 pyramidal neuron spine compartment with the following: glutamate receptors (AMPARs, NMDARs (with voltage dependence)), the appropriate voltage sensitive calcium channels (CaV3, CaV1.2/1.3 and CaV2.2/2.3), and SK channels (with intracellular Ca dependence). It is also necessary to accurately model local Ca buffering and diffusion. We would also like to include a dendrite compartment that is electrically and diffusionally coupled to the spine.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 我们想将树突状的脊柱建模为兴奋性突触及其相关的母体树突。虚拟单元以电压敏感的方式对离子通量建模的能力为此提供了一个强大而独特的框架。具体目标是对生理上精确的CA1锥体神经元脊柱室进行建模，其中包括：谷氨酸受体（AMPARS，NMDARS（具有电压依赖性）），适当的电压敏感钙通道（CAV3，CAV3，CAV1.2/1.3和CAV2.2/2.3和CAV2.2/2.3），以及Interacellular Caillular caellular caellular caellular ca。还必须准确地对局部CA缓冲和扩散进行建模。我们还想包括一个与脊柱耦合的树突室。