Iron Status at Perimenopause: Effects on Brain and Behavior

围绝经期的铁状况：对大脑和行为的影响

• 批准号: 9788455
• 负责人: MICHAEL J WENGER
• 金额: $ 19.57万
• 依托单位: UNIVERSITY OF OKLAHOMA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9788455
• 关键词: Address; Adverse effects; Affect; Age; Amenorrhea; Attention; Behavior; Behavioral; Blood; Brain; Brain region; Brain scan; Cognition; Cognitive; Data; Dependence; Deposition; Disease; Elderly; Ferritin; Hemorrhage; Impaired cognition; Iron; Iron deficiency anemia; Learning; Life; Link; Literature; Longitudinal Studies; Measures; Memory; Menarche; Menopause; Motivation; National Health and Nutrition Examination Survey; Nature; Nerve Degeneration; Oxidative Stress; Parkinson Disease; Performance; Perimenopause; Physical Performance; Play; Postmenopause; Premenopause; Race; Rest; Risk; Role; Structure; System; Testing; Time; Variant; Woman; Work; age group; age related; behavior measurement; brain behavior; brain health; brain tissue; child bearing; cognitive function; cognitive performance; examination questions; high risk; iron deficiency; neurophysiology; procedural memory; recruit

Project summary/abstract From the onset of menarche, through the child-bearing years, a substantial number of women worldwide are challenged by iron deficiency (ID) or iron deficiency anemia (IDA). The negative effects of ID include deficits in cognitive and physical performance. At and following menopause, however, the nature of the relationship between iron status and both cognitive performance and brain health is much more ambiguous, and the literature on these relationships is quite sparse, in spite of evidence suggesting that brain iron accumulation may play a role in neural degeneration and cognitive decline. One intriguing potential regularity in the literature is an inverse relationship between systemic levels of ferritin and performance on a range of memory tasks in peri- and post-menopausal women. This suggests that amenorrhea may produce differential changes in brain iron for women who are ID or IDA at or prior to menopause relative to those who are not. There are at least two competing possibilities. First, when blood loss stops, brain iron levels may accelerate in a manner inversely proportional to systemic iron levels. For ID women, this may reverse any deficits that may be due to ID, but accelerate the negative effects of iron deposits (including oxidative stress) in specific brain regions, including those critical to attention and memory. Second, the rate of brain iron accumulation may have no relationship to iron status at menopause. For women who are ID, this would mean that brain iron levels, although increasing over time (and thus, eventually, reversing any ID-related deficits) would remain lower than those of women who are iron sufficient (IS), possibly conferring a protective benefit with respect to the adverse effects of accumulating iron on brain tissue and function. The ability to address these possibilities depends on the feasibility of measuring relationships among levels of iron in the blood, levels of iron in brain in regions known to be involved in specific aspects of cognition, brain dynamics during cognitive work and at rest, and behavioral measures of specific aspects of cognition. This project will be, to our knowledge, the first to assess the feasibility of assessing all of these relationships. A set of non-anemic pre-, peri-, and post-menopausal women, half of whom have low levels of blood iron and half of whom are sufficient, will provide structural brain scans for region-specific estimates of brain iron. They will be tested on behavioral measures of cognitive performance that selectively engage those regions while having brain activity measured using electroencephelography (EEG), and will also have EEG recorded during two periods of rest. All of this will allow for the first known quantitative characterization of the relationships among blood and brain iron levels, brain dynamics (both at work and at rest), and behavior, all relative to the onset of menopause. This cross-sectional characterization will provide the data that are critically needed for an efficient longitudinal examination of these questions, and will represent a unique contribution to a now-sparse literature on the relationship between iron and brain health and cognition in women in later life.

项目摘要/摘要 从初潮开始到育儿年，全球大量女性是 受铁缺乏症（ID）或铁缺血（IDA）的挑战。 ID的负面影响包括在 认知和身体表现。然而，在更年期和之后， 铁地位以及认知表现和大脑健康都更加模棱两可，有关这些的文献 尽管有证据表明脑铁的积累可能在神经元中起作用，但关系很少 退化和认知能力下降。 文献中一种有趣的潜在规律性是全身铁蛋白水平之间的反比关系 以及绝经后妇女的一系列记忆任务的表现。这表明闭经可能会使ID或IDA的女性在更年期相对的ID或IDA的女性中产生不同的变化 对于那些没有的人。至少有两种竞争可能性。首先，当失血停止时，脑铁水平 可能以与全身铁的水平成反比的方式加速。对于身份女性，这可能会扭转任何 可能是由于ID引起的，但加速了铁沉积物的负面影响（包括氧化应激） 特定的大脑区域，包括对注意力和记忆至关重要的区域。其次，脑铁的积累速率可能与更年期的铁状态没有关系。对于身份证的女性，这意味着大脑 铁水平虽然随着时间的推移会增加（因此，最终逆转与ID相关的任何相关的删除）将仍然存在 低于铁能层的女性（IS），可能会赋予受保护的受益 累积铁对脑组织和功能的不利影响。 解决这些可能性的能力取决于测量级别之间关系的可行性 血液中的铁，已知与认知特定方面的大脑中的铁水平 认知工作和休息期间的动态以及认知特定方面的行为测量。这个项目 据我们所知，将首先评估评估所有这些关系的可行性。一组非动物前，周期和绝经后妇女，其中一半的血液水平较低，其中一半 具有足够的能力，将为脑铁的区域特异性估计提供结构性脑扫描。他们将在 认知表现的行为度量，有选择地参与这些区域，同时进行大脑活动 使用电脑摄影（EEG）测量，还将在两个休息期间记录EEG。全部 其中将允许对血液和脑铁之间关系的第一个已知的定量表征 级别，大脑动力学（在工作和休息时）和行为，都是相对于更年期开始的。这种横截面表征将提供有效纵向检查至关重要的数据 在这些问题中，它将代表有关现在关于现在有关的关于关系的独特贡献 以后的女性铁与大脑健康和认知。