Characterizing the prevalence and nature of facial recognition deficits in non-proliferative diabetic retinopathy

描述非增殖性糖尿病视网膜病变中面部识别缺陷的患病率和性质

• 批准号: 10667781
• 负责人: MICHAEL J WENGER
• 金额: $ 19.21万
• 依托单位: UNIVERSITY OF OKLAHOMA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10667781
• 关键词: Address; Affect; Age; Age related macular degeneration; American; Architecture; Attention; Background Diabetic Retinopathy; Behavior Therapy; Blindness; Complex; Contrast Sensitivity; Detection; Diabetes Mellitus; Diabetic Retinopathy; Diffuse; Early identification; Experimental Designs; Face; Face Processing; Glaucoma; Goals; Hemorrhage; Impairment; Individual; Intervention; Literature; Measures; Mediating; Medical; Memory; Microaneurysm; Modeling; Monitor; Nature; Neuropsychology; Oklahoma; Pathology; Patient Self-Report; Patients; Pattern; Perception; Performance; Prevalence; Quality of life; Questionnaires; Race; Reading; Reporting; Research; Retinal Diseases; Retinal Neovascularization; Sampling; Severities; Structural defect; Symptoms; Systems Theory; Translating; Variant; Venous; Vision; Visual; Visual Acuity; Well in self; Work; age group; cognitive function; experience; face perception; macula; macular edema; novel; proliferative diabetic retinopathy; reading difficulties; recruit; sex; skills; social; systematic review; theories; vascular abnormality; visual memory

Project summary/abstract Facial perception and memory are visual abilities that are driven by an interplay between low-level visual and higher-level cognitive functioning. Deficits in facial perception and memory are associated with diminished quality of life and a range of social challenges, and it has been suggested that this functional deficit may be an early marker for the later onset of structural abnormalities in a variety of conditions. One of these conditions—one that has received scant attention—is diabetic retinopathy. In a recent systematic review, difficulty in perceiving faces was noted as one of the greatest subjective restrictions on visual functioning. Diabetic retinopathy affects approx- imately one-third of individuals with diabetes world-wide. The vision loss associated with diabetic retinopathy is preventable, given early identification, medical intervention and monitoring, and behavioral interventions. Diabetic retinopathy can be generally separated into two classes. The first is non-proliferative diabetic retinopathy, which is characterized by micro-aneurysms, intraretinal hemorrhages, venous beading or intra-retinal microvascular ab- normalities. The second is proliferative diabetic retinopathy, which is characterized by retinal neovascularization. In cases of macular edema, there is a thickening of the macula which can result in the loss of central vision. Deficits in face processing have been studied more frequently in two pathologies that affect the macula: age- related macular degeneration (AMD) and glaucomatous macular damage. Patients with AMD regularly identify facial processing as tasks with which they experience significant difficulty. In the literature on AMD, deficits in facial processing have been identified as significant components of quality of life. The magnitude of the deficits in facial processing in AMD are such that they are second only to deficits in reading in subjective complaints. Finally, it has been noted that deficits in facial processsing are among the first subjectively-reported symptoms of AMD, often occurring before the detection of structural abnormalities. With respect to deficits in facial percep- tion and memory in glaucomatous macular damage, there is evidence that significant impairments exist despite patients having good central visual acuity. In addition, the amount of the diffuse macular damage is significantly related to impairments in contrast sensitivity and measures of facial recognition and identification. It has been suggested that other related visual pathologies—including diabetic retinopathy—should show similar patterns of performance deficits. However, very little work on this issue has been done in the case of diabetic retinopa- thy. The work proposed here represents an important first step in addressing this need. The accomplishment of this work will result in the first quantification of the prevalence and severity of deficits in facial processing in diabetic retinopathy, the first analytic empirical treatment of the pathology-related differences in processing feat- ural and configural information, and the first theoretical treatment of those differences. The novel application of two meta-theories using a new experimental design, along with a modeling approach capable of relating those meta-theories has the potential to be transformative in this domain.

项目摘要/摘要 面部感知和记忆是视觉能力，由低级视觉和 高级认知功能。面部感知和记忆中的陈述与质量降低有关 生活和一系列社会挑战，有人提出这种功能性的定义可能是早期的 在多种条件下结构异常发作的后来发作的标记。这些条件之一 - 一个 受到糖尿病性视网膜病的关注很少。在最近的系统评价中，在感知面孔的困难 糖尿病性视网膜病影响近似 全世界有三分之一的糖尿病患者。与糖尿病性视网膜病有关的视力丧失是 可以预防，鉴于早期识别，医疗干预和监测以及行为干预措施。糖尿病 视网膜病通常可以分为两类。第一个是非增殖的糖尿病性视网膜病， 其特征是微动瘤，视网膜内出血，静脉串珠或视网膜内微血管AB- 正常。第二个是增殖的糖尿病性视网膜病，其特征是视网膜新生血管化。 在黄斑水肿的情况下，黄斑的增厚会导致中央视力的丧失。 在影响黄斑的两种病理学中，脸部处理中的遗嘱量更高：年龄 - 相关的黄斑变性（AMD）和青光眼黄斑损伤。 AMD经常识别的患者 面部处理是他们经历了重要的困难的任务。在有关AMD的文献中，在 面部加工已被确定为生活质量的重要组成部分。定义的大小 在AMD中的面部处理中，它们仅在主观投诉中仅次于阅读。 最后，已经注意到，面部处理中的陈述是第一个主观报告的符号之一 AMD，通常发生在检测结构异常之前。关于面部感知中的删节 青光眼黄斑损害中的造成和记忆，有证据表明目的地存在显着障碍 患者具有良好的中央视力。另外，弥漫性黄斑损伤的量显着 与对比度敏感性以及面部识别和识别措施的损害有关。它一直 提出其他相关的视觉病理（包括糖尿病性视网膜病）应该显示出类似的模式 绩效删节。但是，在糖尿病性视网膜的情况下，几乎没有完成此问题的工作 你这里提出的工作代表了满足这一需求的重要第一步。成就 这项工作将导致对面部处理中的患病率和严重程度的第一个量化 糖尿病性视网膜病，是与病理相关的处理效果差异的第一个分析经验治疗 乌拉尔和构造信息，以及这些差异的第一个理论处理。新颖的应用 使用新的实验设计的两种元理论，以及一种能够将其关联的建模方法 元理论有可能在该领域具有变革性。