Changes in Memory Capacity across the Lifespan

整个生命周期内存容量的变化

• 批准号: 6684354
• 负责人: MICHAEL J WENGER
• 金额: $ 7.18万
• 依托单位: UNIVERSITY OF NOTRE DAME
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-15 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6684354
• 关键词: age difference; aging; behavioral /social science research tag; clinical research; cognition; cognition disorders; human middle age (35-64); human old age (65+); human subject; learning; memory; neural information processing; psychological aspect of aging; psychological tests; statistics /biometry; young adult human (21-34)

The proposed work seeks to examine the possible age- and disease-related changes in the real-time capacity of memory processing. A novel measure of processing capacity, based on response latencies, will be added to a performance measure that has been sensititive in detecting memory impairment (the Free and Cued Selective Reminding Test). Processing capacity will be compared in three groups of healthy adults: college-aged, middle-aged, and elderly. In addition, processing capacity in healthy elderly adults will be compared to processing capacity in elderly adults with mild cognitive impairment. It is expected that age- and disease-related changes in capacity will be detected, demonstrating the potential for augmenting diagnostic tools and providing additional insight into the nature of normal age-related changes in memory. Use of this measure requires application of novel statistical tools; consequently, this work will provide a demonstration of the utility and applicability of these statistical techniques.

拟议的工作旨在检查记忆处理实时能力的可能与年龄和疾病相关的变化。基于响应潜伏期的处理能力的新颖措施将添加到一种在检测记忆障碍（免费和提示的选择性提醒测试）方面敏感的性能度量。将在三组健康的成年人中比较加工能力：大学生，中年和老年人。此外，健康成年人的加工能力将与患有轻度认知障碍的老年人的加工能力进行比较。预计将检测到与年龄和疾病相关的容量变化，这表明了增加诊断工具的潜力，并提供了对正常年龄相关记忆变化的性质的更多见解。使用此措施需要应用新颖的统计工具；因此，这项工作将提供这些统计技术的实用性和适用性。

项目成果

Modeling and Estimating Recall Processing Capacity: Sensitivity and Diagnostic Utility in Application to Mild Cognitive Impairment.

• DOI: 10.1016/j.jmp.2009.04.012
• 发表时间: 2010-02-01
• 期刊: Journal of mathematical psychology
• 影响因子: 1.8
• 作者: Wenger MK;Negash S;Petersen RC;Petersen L
• 通讯作者: Petersen L