Integrating Wastewater-Based Epidemiology into the National Drug Early Warning System Coordinating Center to Track Community Health Trends

将基于废水的流行病学纳入国家药物预警系统协调中心，以跟踪社区健康趋势

• 批准号: 10375878
• 负责人: Linda B. Cottler
• 金额: $ 15.25万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10375878
• 关键词: Address; Amphetamines; Behavior; Biological; Businesses; COVID-19; Chemicals; Chemistry; Collection; Communication; Communities; Community Health; Complement; Consumption; Data; Data Set; Drug Targeting; Drug abuse; Drug usage; Economics; Environmental Health; Epidemiology; Event; Fentanyl; Festival; Fingerprint; Florida; Health; Health Professional; Health trends; Heroin; Hot Spot; Hour; Human; Individual; Industry; Legal; Life Style; Location; Mass Spectrum Analysis; Measurement; Measures; Methods; Monitor; Parents; Patient Self-Report; Pattern; Pharmaceutical Preparations; Plants; Population; Population Sizes; Prevalence; Process; Public Health; Quarantine; Sampling; Scientist; Sentinel; Site; Sports; Surveys; System; Techniques; Testing; Time; Toxicology; Universities; Urban Community; Validation; Visualization software; Water; Work; aged; analog; base; cost; cost effective; data dissemination; data integration; epidemiologic data; epidemiology study; fighting; global health; illicit drug use; innovation; interest; multidisciplinary; new therapeutic target; novel; novel therapeutics; programs; public health intervention; rapid technique; response; sample collection; substance use; success; surveillance data; surveillance study; tool; trend; wastewater epidemiology; wastewater samples; wastewater screening

SUMMARY Wastewater-based epidemiology (WBE) is an innovative and cost-effective approach that complements traditional, yet important, self-reporting methods and biospecimen testing to construct drug use trends on a community scale. WBE has been successfully applied to estimate consumption of targeted illegal drugs and has more recently been applied to detect the emergence of new psychoactive substances (NPS) in varied settings such as large urban communities and during/after smaller focused events (e.g., festivals, sports events). Yet, this approach has not formally been integrated into the National Drug Early Warning System (NDEWS) Coordinating Center, a platform which provides experts and communities with the most timely information on emerging substance use trends through traditional and novel surveillance data as well as on- the-ground epidemiologic investigations. Therefore this proposal aims to provide accurate up-to-date wastewater chemical/drug surveillance data from designated partner sites of the NDEWS Coordinating Center and wastewater industry, calculate drug consumption over time, and align our approach with existing NDEWS surveillance data to help identify hot spots or new emerging trends across communities on a national scale. This will be accomplished through 2 aims: 1) Coordinate collection and analysis of wastewater samples from NDEWS Sentinel Site locations for known drugs/metabolites and NPS using high-end mass spectrometry approaches and 2) Validate and disseminate actionable WBE data by comparing data from on-going drug use surveillance studies as part of NDEWS with WBE generated drug trends, integrate WBE data with public health and utility information to develop a visualization tool and disseminate information via the NDEWS Coordinating Center and through 2 way regular communication with our water industry and public health partners and their local communities. Our proof-of-concept proposal will provide the benefits of easy integration of WBE into the existing NDEWS framework, and data sets that are immediately available to the NDEWS partners which will, importantly, inform current and emerging drug use trends that can be used to refine public health measures.

概括 基于废水的流行病学（WBE）是一种创新且具有成本效益的方法，可补充 传统但重要的自我报告方法和生物测量测试，以构建在A上的毒品使用趋势 社区规模。 WBE已成功应用于估计有针对性的非法药物的消费 最近，应用于检测新的精神活性物质（NP）的出现 大型城市社区以及小型集中活动之后的设置（例如，节日，体育运动 事件）。但是，这种方法尚未正式纳入国家药物预警系统 （NDEWS）协调中心，一个平台，为专家和社区提供最及时的专家和社区 通过传统和新颖的监视数据以及On-的信息信息 地面流行病学研究。因此，该建议旨在提供准确的最新 来自NDEWS的指定合作伙伴站点的废水化学/药物监视数据协调 中心和废水行业，随着时间的推移计算药物消耗，并使我们的方法与 现有的NDEWS监视数据，以帮助识别跨越热点或新的新兴趋势 国家规模上的社区。这将通过2个目标来完成：1）协调收集和 分析已知药物/代谢物和NP的NDEWS Sentinel位置位置的废水样品 使用高端质谱法和2）通过 比较正在进行的药物使用监视研究的数据作为NDEWS的一部分 趋势，将WBE数据与公共卫生和公用事业信息整合在一起，以开发可视化工具和 通过NDEWS协调中心和两条定期沟通来传播信息 我们的水产行业和公共卫生伙伴及其当地社区。我们的概念证明的建议将 提供轻松将WBE集成到现有NDEWS框架中的好处，以及 NDEWS合作伙伴立即可用，这些合作伙伴将为当前和新兴的毒品使用提供信息 可用于完善公共卫生措施的趋势。