Harmonizing Wastewater Generated Drug Consumption Trends with Epidemiological Indicators in NDEWS

将废水产生的药物消费趋势与 NDEWS 中的流行病学指标相协调

• 批准号: 10885405
• 负责人: Linda B. Cottler
• 金额: $ 50.13万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10885405
• 关键词: Address; Adopted; Amphetamines; Biological; Biological Markers; Biometry; Buprenorphine; Cessation of life; Chemicals; Chemistry; Chicago; Cities; Cocaine; Communities; Consumption; Data; Data Analyses; Detection; Development; Drug Targeting; Drug usage; Engineering; Epidemic; Epidemiology; Excretory function; Fentanyl; Frequencies; Funding; Generations; Geography; Goals; Health; Health Professional; Hot Spot; Hour; Human; Individual; Ketamine; Knowledge; Liquid substance; Literature; Location; Maps; Marketing; Measurement; Measures; Methadone; Methamphetamine; Methodology; Methods; Modeling; Morphine; Naloxone; Names; National Institute of Drug Abuse; Opioid; Overdose; Patient Self-Report; Pattern; Persons; Pharmaceutical Preparations; Philadelphia; Pilot Projects; Plants; Population; Prevention; Process; Public Health; Reporting; Research; Research Personnel; Rural Community; Sampling; Science; Secure; Sentinel; Signal Transduction; Site; Specialist; Stream; Surveillance Methods; Surveillance Program; Surveys; System; Testing; Time; Toxicology; Trust; United States; Visual; Visualization software; Work; Xylazine; benzoylecgonine; data dissemination; data harmonization; data integration; data streams; epidemiologic data; fentanyl analog; fighting; health data; illicit drug use; innovation; manufacture; mortality; multidisciplinary; novel therapeutics; population health; programs; public health intervention; response; substance use; success; surveillance data; surveillance network; surveillance study; synthetic opioid; tool; trend; wastewater epidemiology; wastewater samples; wastewater sampling; wastewater surveillance

ABSTRACT Nearly 1 million individuals have died from drug overdoses over the past two decades with the most recent mortality surges associated with opioids, namely fentanyl. Surveillance programs are critical to understanding community drug trends, yet traditional methods (e.g. surveys) are not designed to inform on such trends as they are emerging. Wastewater-based epidemiology (WBE) is an innovative approach that can identify community drug use patterns as they change and shift in near real-time, data that is critical to developing effective public health responses. Community-level drug trends have been successfully generated from wastewater for substances of current concern (e.g., fentanyl); however, implementation of WBE as a holistic framework that contributes reliable, consistent, and trusted data to stakeholders is urgently needed. Several notable gaps within this framework include the need for advanced wastewater sampling strategies, rapid and accurate identification of emergent and/or novel drugs, and integration of wastewater traditional surveillance data. Therefore, the overall objective of this proposal is to enhance the utility of WBE as an early warning system to effectively drive public health measures in impacted communities. This will be accomplished through two comprehensive specific aims that include: (1) the generation of optimal sampling regimes by considering time, granularity, frequency and the detection of new psychoactive substances as they emerge, (2) harmonization of WBE and existing epidemiologic data for analysis, interpretation, and timely dissemination through customized visualization tools. This research will be an extension of a recently completed pilot study of wastewater surveillance of fentanyl in four United States cities. Comprised of a diverse team of researchers and community partners, GatorWATCHTM has secured the required multidisciplinary expertise that has already shown success. Furthermore, integration with the National Drug Early Warning System (NDEWS) Coordinating Center will afford us an expansive network for WBE expansion and dissemination of our results. Collectively, through advancing drug measurement methodology in tandem with sophisticated data harmonization will provide a blueprint for expansion and use of WBE as an integral part of public health interventions in the fight against contemporary and emerging drug use epidemics in our communities nationwide.

抽象的 在过去的二十年中，有近100万人死于药物过量，最近 与阿片类药物有关的死亡率激增，即芬太尼。监视计划对于理解至关重要 社区毒品趋势，但传统方法（例如调查）并非旨在告知趋势 正在出现。基于废水的流行病学（WBE）是一种创新的方法，可以识别社区 药物使用模式在接近实时发生变化和转移时，数据对于发展有效公众至关重要 健康反应。社区级的药物趋势已从废水中成功产生 当前关注的物质（例如芬太尼）；但是，实施WBE作为一个整体框架 迫切需要为利益相关者提供可靠，一致和可信赖的数据。其中几个显着的差距 该框架包括需要先进的废水采样策略，快速准确的识别 新兴和/或新型药物，以及废水传统监视数据的整合。因此，整体 该提案的目的是增强WBE作为预警系统有效推动公众的效用 受影响社区的健康措施。这将通过两个全面的特定目标来完成 其中包括：（1）通过考虑时间，粒度，频率和 发现新的精神活性物质的发现，（2）WBE和现有流行病学的协调 通过自定义可视化工具进行分析，解释和及时传播的数据。这项研究 将是最近完成的四个联合芬太尼废水监视的试点研究的扩展 国家城市。 GatorWatchTM由一个多元化的研究人员和社区合作伙伴组成，已确保 已经表现出成功的所需的多学科专业知识。此外，与 国家药物预警系统（NDEWS）协调中心将为我们提供一个广阔的网络 扩展和传播我们的结果。共同通过推进药物测量方法 与复杂数据协调的串联将为扩展和使用WBE作为一个蓝图 公共卫生干预措施不可或缺的一部分，反对当代和新兴药物使用流行 我们的全国社区。