DETECTION OF MALARIA INFECTION IN ERYTHROCYTES BY RAMAN MICRO-SPECTROSCOPY

拉曼显微光谱法检测红细胞中的疟疾感染

• 批准号: 8364155
• 负责人: ISHAN BARMAN
• 金额: $ 2.97万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364155
• 关键词: Accounting; Africa South of the Sahara; Biomedical Research; Blood; Cessation of life; Creatinine; Detection; Erythrocytes; Funding; Glucose; Grant; Infection; Lasers; Malaria; Malaria Vaccines; Methods; National Center for Research Resources; Principal Investigator; Public Health; Raman Spectrum Analysis; Research; Research Infrastructure; Resources; Source; Spectrum Analysis; Staging; United States National Institutes of Health; Urea; cost; in vivo; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Malaria remains one of the largest public health problems accounting for nearly three million deaths a year in the world, primarily in sub-Saharan Africa. In the absence of a truly effective malarial vaccine, it is critical that early stage detection efforts are prioritized  especially if such a highly sensitive method can be implemented non-invasively. Near infrared (NIR) Raman spectroscopy potentially provides an excellent tool to probe malaria in vivo, given its promising track record in transcutaneous detection of blood analytes including glucose, creatinine and urea.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 疟疾仍然是世界上最大的公共卫生问题之一，该问题占全球近300万人死亡，主要是撒哈拉以南非洲。在没有真正有效的疟疾疫苗的情况下，至关重要的是要优先考虑早期阶段检测工作，尤其是如果可以非侵入性地实施这种高度敏感的方法。鉴于其在葡萄糖，肌酐和尿素（包括葡萄糖，肌酐和尿素）的经经态检测中，近红外（NIR）拉曼光谱学可能为体内探测疟疾提供了出色的工具。