NONINVASIVE MEASUREMENT OF BLOOD ANALYTES

血液分析物的无创测量

• 批准号: 7722786
• 负责人: ISHAN BARMAN
• 金额: $ 2.86万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722786
• 关键词: Blood; Clinical; Computer Retrieval of Information on Scientific Projects Database; Detection; Effectiveness; Error Sources; Forearm; Funding; Glucose; Goals; Grant; Healthcare; In Vitro; Institution; Measurement; Methods; Patients; Photons; Population; Raman Spectrum Analysis; Research; Research Personnel; Resources; Sampling; Source; Technology; Tissues; United States National Institutes of Health; clinically relevant; diabetic; human subject; improved; in vivo; migration; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is the measurement of clinically-relevant analytes in the blood tissue matrix of human subjects using near-infrared Raman spectroscopy. Such a technology could have great impact on the healthcare practices for the entire population, with the shorter term research directed towards glucose measurements for diabetic patients. We have recently demonstrated detection feasibility of glucose concentrations in vivo from transcutaneous measurements of the forearm. From these measurements we discovered that one important source of error is variability in sample turbidity. As a result, we have developed a method for the correction of turbidity-induced distortions in Raman spectra utilizing the photon migration approach. We are currently performing in vitro studies to demonstrate the effectiveness of this method in improving prospective prediction. This will be followed by in vivo studies to demonstrate the feasibility of the detection of blood analytes with clinical accuracy.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目的目标是使用近红外拉曼光谱测量人类受试者血液组织基质中的临床相关分析物。这种技术可能会对整个人群的医疗保健实践产生巨大影响，短期研究将针对糖尿病患者的血糖测量。我们最近证明了通过前臂的经皮测量来检测体内葡萄糖浓度的可行性。从这些测量中，我们发现误差的一个重要来源是样品浊度的变化。因此，我们开发了一种利用光子迁移方法校正拉曼光谱中浑浊引起的畸变的方法。我们目前正在进行体外研究，以证明该方法在改善前瞻性预测方面的有效性。随后将进行体内研究，以证明以临床准确性检测血液分析物的可行性。