NONINVASIVE MEASUREMENT OF BLOOD ANALYTES

血液分析物的无创测量

• 批准号: 7955842
• 负责人: ISHAN BARMAN
• 金额: $ 2.85万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955842
• 关键词: Biomedical Research; Blood; Clinical; Computer Retrieval of Information on Scientific Projects Database; Detection; Effectiveness; Error Sources; Forearm; Funding; Glucose; Goals; Grant; Healthcare; In Vitro; Institution; Lasers; Measurement; Methods; Photons; Population; Raman Spectrum Analysis; Research; Research Personnel; Resources; Sampling; Source; Technology; Tissues; United States National Institutes of Health; clinically relevant; diabetic patient; human subject; improved; in vivo; migration; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is the measurement of clinically-relevant analytes in the blood tissue matrix of human subjects using near-infrared Raman spectroscopy. Such a technology could have great impact on the healthcare practices for the entire population, with the shorter term research directed towards glucose measurements for diabetic patients. We have recently demonstrated detection feasibility of glucose concentrations in vivo from transcutaneous measurements of the forearm. From these measurements we discovered that one important source of error is variability in sample turbidity. As a result, we have developed a method for the correction of turbidity-induced distortions in Raman spectra utilizing the photon migration approach. We are currently performing in vitro studies to demonstrate the effectiveness of this method in improving prospective prediction. This will be followed by in vivo studies to demonstrate the feasibility of the detection of blood analytes with clinical accuracy.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目的目的是使用近红外拉曼光谱法测量人类受试者的血液组织基质中临床相关的分析物。这样的技术可能会对整个人群的医疗保健实践产生重大影响，而较短的一项研究针对糖尿病患者的葡萄糖测量。最近，我们证明了从前臂的经皮测量值中葡萄糖浓度在体内的可行性。从这些测量值我们发现，一个重要的错误来源是样本浊度的变化。结果，我们开发了一种使用光子迁移方法校正拉曼光谱中浊度诱导的扭曲的方法。我们目前正在进行体外研究，以证明该方法在改善前瞻性预测方面的有效性。随后将进行体内研究，以证明以临床精度检测血液分析物的可行性。