Training in emerging infectious diseases

新发传染病培训

• 批准号: 8301668
• 负责人: Robert W. Doms
• 金额: $ 23.67万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8301668
• 关键词: Emerging Communicable Diseases; Training

In response to increased concern about emerging and re-emerging infectious diseases, particularly Class A-C agents that could be used as weapons of bioterrorism, the microbiology community at the University of Pennsylvania proposes to establish a Training Program in Emerging Infectious Diseases. The Training Program would initially support two Ph.D. and two M.D./Ph.D. or V.M.D./Ph.D. predoctoral fellows as well as three postdoctoral fellows, enabling them to work in any one of 14 laboratories directed by principle investigators who study important viral or parasitic pathogens that are classified as either emerging or re- emerging threats to human health. The trainers associated with this T32 proposal have been selected because their research programs in these areas are well established, being supported by NIH grants and/or having published papers on this topic. The trainers study a number of important viral and parasitic pathogens. Six of the trainers on this grant study smallpox proteins or are developing anti-vaccinia agents, and currently hold 1 R01, 2 R21 and 1 U01 grants to support work in this area (Isaacs, Rosengard, Cohen, Eisenberg, Friedman, Ricciardi). Four trainers on this grant study Ebola virus, holding 1 R01 and 2 R21 grants and having published several papers in the last two years (Bates, DoTs, Shen, Harty). Collaborations with colleagues at USAMRIID make it possible to perform experiments with live Ebola virus. Other important emerging viral diseases that are subjects of significant research efforts by the trainers include West Nile virus and Dengue (DoTs, Bates). Emerging and re-emerging parasitic diseases are the focus of research efforts by the trainers include Malaria, a major focus of the Roos laboratory which plays a major role in managing the Plasmodium genome project. Outbreaks of leishmaniasis (Scott) in Afghan refugee camps in Pakistan and other regions, have demonstrated increased incidence of old infections from a confluence of wars, population shifts, and development into little populated regions. Due to climactic changes and large-scale water resources development projects, there have been notable new outbreaks of schistosomiasis in previously unaffected areas (Pearce, Shen). Increased infections due to toxoplasma gondii have also been reported (Roos, Hunter). With time, we anticipate that other Penn investigators will join this training program as they shift their research focus to include emerging infectious diseases. The research opportunities provided by the trainers coupled with strong institutional commitment and an extensive and well organized training program will provide excellent training in emerging infectious diseases to students and postdoctoral fellows.

为了应对对新兴和重新出现的传染病的关注，尤其是A-C类 可以用作生物恐怖武器的特工，大学的微生物学界 宾夕法尼亚州建议建立一项有关新兴传染病的培训计划。培训 计划最初将支持两位博士学位。和两个M.D./ph.d。或V.M.D./PH.D。同时杂物前研究员 作为三个博士后研究员，使他们能够在原则上执导的14个实验室中的任何一个工作 研究重要病毒或寄生病原体的研究人员被归类为新兴或重新 对人类健康的新兴威胁。已经选择了与该T32建议相关的培训师，因为 他们在这些领域的研究计划已得到充分建立，得到了NIH赠款的支持和/或 有关此主题的发表论文。培训师研究了许多重要的病毒和寄生病原体。六个 这项赠款研究的培训师天花蛋白或正在开发抗Vaccinia剂，目前持有1 R01、2 R21和1 U01赠款以支持该领域的工作（Isaacs，Rosengard，Cohen，Eisenberg， 弗里德曼（Ricciardi））。该赠款研究埃博拉病毒的四名培训师，持有1 R01和2 R21赠款， 在过去两年中发表了几篇论文（贝茨，点，沉，哈蒂）。与之合作 Usamriid的同事可以使用活埃博拉病毒进行实验。另一个重要 培训师大量研究工作的新兴病毒疾病包括西尼罗河病毒 和登革热（点，贝茨）。新兴和重新出现的寄生疾病是研究工作的重点 培训师包括疟疾，Roos实验室的主要重点 疟原虫基因组项目。巴基斯坦阿富汗难民营的利什曼病（斯科特）爆发 其他地区表明，战争融合，人口汇合处的旧感染发生率增加 转变，发展到人口稠密的地区。由于高潮变化和大规模水 资源开发项目，以前有明显的血吸虫病爆发 不受影响的地区（Pearce，Shen）。还报道了由于弓形虫引起的感染增加 （Roos，Hunter）。随着时间的流逝，我们预计其他宾夕法尼亚州的调查人员将加入该培训计划 将他们的研究重点转移到包括新兴的传染病。由 培训师以及强大的机构承诺和广泛且组织良好的培训计划 将为学生和博士后研究员提供出色的新兴传染病培训。