Training in Emerging Infectious Diseases

新发传染病培训

• 批准号: 6915028
• 负责人: Robert W. Doms
• 金额: $ 24.1万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6915028
• 关键词: Training; Emerging; Infectious; Diseases

DESCRIPTION (provided by applicant): In response to increased concern about emerging and re-emerging infectious diseases, particularly Class A-C agents that could be used as weapons of bioterrorism, the microbiology community at the University of Pennsylvania proposes to establish a Training Program in Emerging Infectious Diseases. The Training Program would initially support two Ph.D. and two M.D./Ph.D. or V.M.D./Ph.D. predoctoral fellows as well as three postdoctoral fellows, enabling them to work in any one of 14 laboratories directed by Principal Investigators who study important viral or parasitic pathogens that are classified as either emerging or re-emerging threats to human health. The trainers associated with this T32 proposal have been selected because their research programs in these areas are well-established and are being supported by NIH grants and/or have published papers on this topic. The trainers study a number of important viral and parasitic pathogens. Six of the trainers on this grant study smallpox proteins or are developing anti-vaccinia agents, and currently hold one R01, two R21s and one U01 grants to support work in this area (Isaacs, Rosengard, Cohen, Eisenberg, Friedman, Ricciardi). Four trainers on this grant study Ebola virus, holding one R01 and two R21 grants and having published several papers in the last two years (Bates, DoTs, Shen, Harty). Collaborations with colleagues at USAMRIID make it possible to perform experiments with live Ebola virus. Other important emerging viral diseases that are subjects of significant research efforts by the trainers include West Nile virus and Dengue (DoTs, Bates). Emerging and re-emerging parasitic diseases are the focus of research efforts by the trainers and include Malaria, a major focus of the Roos laboratory which plays a major role in managing the Plasmodium genome project. Outbreaks of leishmaniasis (Scott) in Afghan refugee camps in Pakistan and other regions, have demonstrated increased incidence of old infections from a confluence of wars, population shifts, and development into little populated regions. Due to climactic changes and large-scale water resources development projects, there have been notable new outbreaks of schistosomiasis in previously unaffected areas (Pearce, Shen). Increased infections due to toxoplasma gondii have also been reported (Roos, Hunter). With time, we anticipate that other Penn investigators will join this training program as they shift their research focus to include emerging infectious diseases. The research opportunities provided by the trainers coupled with strong institutional commitment and an extensive and well-organized training program will provide excellent training in emerging infectious diseases to students and postdoctoral fellows.

描述（由申请人提供）：为了回应人们对新兴和重新出现的传染病的越来越关注，尤其是可以用作生物恐怖武器的A-C类药物，宾夕法尼亚大学的微生物学界提议在新兴的感染性疾病中建立培训计划。培训计划最初将支持两位博士学位。和两个M.D./ph.d。或V.M.D./PH.D。前专家们以及三名博士后研究员，使他们能够在研究重要病毒或寄生病原体的主要研究人员指导的14个实验室中工作，这些病原体被归类为新兴或重新出现对人类健康的威胁。之所以选择与该T32提案相关的培训师，是因为他们在这些领域的研究计划已经建立了良好的知识，并得到了NIH赠款的支持和/或已发表了有关此主题的论文。培训师研究了许多重要的病毒和寄生病原体。这项赠款研究天花蛋白的六个培训师或正在开发抗Vaccinia剂，目前持有一名R01，两个R21和一项U01赠款，以支持该地区的工作（Isaacs，Rosengard，Rosengard，Cohen，Eisenberg，Eisenberg，Friedman，Friedman，Friedman，Ricciardi）。该赠款研究埃博拉病毒的四名培训师持有一项R01和两项R21赠款，并在过去两年中发表了几篇论文（Bates，Dots，Shen，Harty）。与Usamriid的同事合作使使用活埃博拉病毒进行实验成为可能。其他重要的新兴病毒疾病是培训师重大研究工作的受试者的其他重要病毒疾病，包括西尼罗河病毒和登革热（DOTS，BATES）。新兴和重新出现的寄生疾病是培训师研究工作的重点，包括疟疾，疟疾是Roos实验室的主要重点，该实验室在管理疟原虫基因组项目中起着重要作用。巴基斯坦和其他地区阿富汗难民营的利什曼病（斯科特）的爆发表明，战争融合，人口转变和发展到人口稠密地区的旧感染发生率增加。由于高潮的变化和大规模的水资源开发项目，在以前未受影响的地区（Pearce，Shen）出现了明显的血吸虫病爆发。据报道，由于弓形虫弓形虫引起的感染增加（Roos，Hunter）。随着时间的流逝，我们预计其他宾夕法尼亚州调查人员将加入该培训计划，因为他们将研究重点转移到包括新兴的传染病。培训师提供的研究机会以及强大的机构承诺以及广泛且组织良好的培训计划将为学生和博士后研究员提供出色的培训。