The Early Growth and Development Study: Family Process, Genes and School Entry

早期成长和发展研究：家庭过程、基因和入学

• 批准号: 8119703
• 负责人: DEBORAH M. CAPALDI
• 金额: $ 162.37万
• 依托单位: OREGON SOCIAL LEARNING CENTER, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8119703
• 关键词: Adolescent; Adoption; Adrenal Glands; Adult; Affect; Age; Age-Months; Anxiety; Behavior; Behavioral; Birth; Characteristics; Child; Child Behavior; Child Mental Health; Data; Data Collection; Development; Developmental Process; Drug usage; Environment; Environmental Risk Factor; Exposure to; Failure; Family; Family Process; Foundations; Genetic; Genetic Risk; Genotype; Growth and Development function; Guide prevention; Hypothalamic structure; Infant; Investigation; Link; Measures; Mediating; Mental Health; Nursery Schools; Outcome; Parent-Child Relations; Parenting behavior; Parents; Pathway interactions; Personal Satisfaction; Personality; Persons; Pharmaceutical Preparations; Phase; Pituitary Gland; Prevention program; Primary Schools; Process; Processed Genes; Psychopathology; Research Personnel; Role; Schools; Social Work; System; Temperament; Toddler; Triad Acrylic Resin; Work; adopted child; anti social; contextual factors; design; early childhood; executive function; externalizing behavior; first grade; hypothalamic-pituitary-adrenal axis; kindergarten; literacy; phase 1 study; prenatal exposure; prevent; programs; prospective; psychosocial; public health relevance; resilience; response; social skills; success; transmission process

DESCRIPTION (provided by applicant): The proposed study is the continuation of the Early Growth and Development Study (EGDS), a prospective adoption design consisting 350 adoption triads (birth parents, adopted child, and adoptive parents). The overarching aim of this work is to study mechanisms of Genotype x Environment (GxE) interaction to identify environmental processes that prevent the expression of genetic risk and promote the expression of genetic resilience. We focus on mechanisms of GxE interaction along three developmental pathways: internalizing behavior, externalizing behavior, and social competence. We also explore hypotheses regarding the role of three early responding systems that are closely linked to these pathways: emergent literacy, HPA axis functioning, and executive functioning. The proposed data collection consists of multimethod, multiagent measures of genetic risk and protective factors, environmental processes, and children's behavioral and neuroregulatory development during the transition to primary school. Success or failure during this transition has long-term implications for children's mental health and drug use. Birth parent in-person assessments are proposed at child age 5, and adoptive family in-person assessments are proposed at ages 41/z, 6 (kindergarten), and 7 (first grade). The following aims are proposed: (1) To identify specific parenting processes that mediate the expression of genetic influences on children's internalizing behavior, externalizing behavior, and social competence (genotype-environment correlation); (2) to identify specific parenting processes and contextual factors that moderate genetic influences on internalizing behavior, externalizing behavior, and social competence (GxE interaction); (3) to identify mechanisms by which parenting and adoptive family contextual factors moderate genotype expression; and (4) to explore early responding systems that may moderate a child's effect on or sensitivity to the family environment. Public Health Relevance: Young children's externalizing and internalizing problems pose critical challenges for families and schools. Children who enter primary school with problems are more likely to struggle academically and to access mental health and social services as adolescents and adults. The proposed work would build an empirical foundation to help guide prevention programs administered in family settings.

描述（由申请人提供）：拟议的研究是早期增长和发展研究（EGD）的延续，这是一种预期的收养设计，其中包括350个收养三合会（亲生父母，收养的孩子和收养父母）。这项工作的总体目的是研究基因型X环境（GXE）相互作用的机制，以确定防止遗传风险表达并促进遗传弹性表达的环境过程。我们专注于沿着三种发展途径的GXE相互作用的机制：内部化行为，外在化行为和社会能力。我们还探讨了有关与这些途径紧密相关的三个早期响应系统的作用的假设：新兴的识字率，HPA轴功能和执行功能。拟议的数据收集包括多途径，遗传风险和保护因素，环境过程以及儿童在过渡到小学期间的行为和神经调节的发展。在这种过渡期间的成功或失败对儿童的心理健康和药物使用具有长期影响。提出了5岁儿童的出生父母面对面评估，并提出了在41/z，6岁（幼儿园）和7（一年级）的收养家庭亲自评估。提出了以下目的：（1）确定介导遗传影响对儿童内在行为，外在化行为和社会能力的表达的特定育儿过程（基因型 - 环境相关）； （2）确定特定的育儿过程和上下文因素，以适应遗传对内在行为，外在行为和社会能力的影响（GXE相互作用）； （3）确定育儿和收养家庭情境因素中等基因型表达的机制； （4）探索可能调节孩子对家庭环境的影响或敏感性的早期响应系统。 公共卫生相关性：幼儿的外在化和内在化问题对家庭和学校构成了关键的挑战。进入小学的儿童更有可能在学术上挣扎，并成为青少年和成人的心理健康和社会服务。拟议的工作将建立一个经验基础，以帮助指导家庭环境中管理的预防计划。

项目成果

The Relationship between Genetic Attributions, Appraisals of Birth Mothers' Health, and the Parenting of Adoptive Mothers and Fathers.

• DOI: 10.1016/j.appdev.2015.06.003
• 发表时间: 2015-11
• 期刊: Journal of applied developmental psychology
• 影响因子: 3
• 作者: Stover CS;Zhou Y;Leve LD;Neiderhiser JM;Shaw DS;Reiss D
• 通讯作者: Reiss D

INFANT AVOIDANCE DURING A TACTILE TASK PREDICTS AUTISM SPECTRUM BEHAVIORS IN TODDLERHOOD.

• DOI: 10.1002/imhj.21539
• 发表时间: 2015-11
• 期刊: Infant mental health journal
• 影响因子: 2.4
• 作者: Mammen MA;Moore GA;Scaramella LV;Reiss D;Ganiban JM;Shaw DS;Leve LD;Neiderhiser JM
• 通讯作者: Neiderhiser JM

Longitudinal pathways from marital hostility to child anger during toddlerhood: genetic susceptibility and indirect effects via harsh parenting.

从婚姻敌意到幼儿期儿童愤怒的纵向途径：遗传易感性和严厉养育的间接影响。

• DOI: 10.1037/a0022886
• 发表时间: 2011
• 期刊: Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)
• 作者: Rhoades,KimberlyA;Leve,LeslieD;Harold,GordonT;Neiderhiser,JenaeM;Shaw,DanielS;Reiss,David
• 通讯作者: Reiss,David

The Intergenerational Transmission of Early Educational Advantages: New Results Based on an Adoption Design.

早期教育优势的代际传递：基于收养设计的新结果。

• DOI: 10.1016/j.rssm.2020.100486
• 发表时间: 2020
• 期刊: Research in social stratification and mobility
• 影响因子: 5
• 作者: Halpern-Manners,Andrew;Marahrens,Helge;Neiderhiser,JenaeM;Natsuaki,MisakiN;Shaw,DanielS;Reiss,David;Leve,LeslieD
• 通讯作者: Leve,LeslieD

Genetic liability, environment, and the development of fussiness in toddlers: the roles of maternal depression and parental responsiveness.

• DOI: 10.1037/a0019659
• 发表时间: 2010-09
• 期刊: DEVELOPMENTAL PSYCHOLOGY
• 影响因子: 4
• 作者: Natsuaki, Misaki N.;Ge, Xiaojia;Leve, Leslie D.;Neiderhiser, Jenae M.;Shaw, Daniel S.;Conger, Rand D.;Scaramella, Laura V.;Reid, John B.;Reiss, David
• 通讯作者: Reiss, David