An adoption study of the development of early substance use: the joint roles of genetic influences, prenatal risk, rearing environment, and pubertal maturation

早期物质使用发展的收养研究：遗传影响、产前风险、抚养环境和青春期成熟的共同作用

• 批准号: 10542479
• 负责人: Jenae M. Neiderhiser
• 金额: $ 5.99万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10542479
• 关键词: Accounting; Address; Adolescence; Adolescent Development; Adoption; Adrenal Glands; Age; Area; Attention; Behavior; Behavioral; Biological; Birth; Cessation of life; Child; Child Behavior; Crime; Data; Development; Developmental Course; Disease; Environment; Environmental Risk Factor; Event; Executive Dysfunction; Family; Genes; Genetic; Growth and Development function; Hair; Health; Height; Heritability; Hormonal; Hormonal Change; Hormones; Hypothalamic structure; Individual; Injury; Investigation; Joints; Knowledge; Life; Link; Literature; Longitudinal Studies; Mediating; Mental Health; Parents; Pathway interactions; Pharmaceutical Preparations; Pituitary Gland; Positioning Attribute; Prevention; Productivity; Puberty; Research; Risk; Risk Behaviors; Role; Sampling; Sampling Studies; Screening procedure; Sex Characteristics; Specificity; Substance Use Disorder; Symptoms; Testing; Time; Triad Acrylic Resin; Work; Youth; addiction; adolescent substance use; adopted child; alcohol use initiation; behavioral outcome; biobehavior; cohort; comorbidity; design; drug use in pregnancy; early adolescence; early satiety; economic cost; externalizing behavior; high risk; improved; indexing; infancy; innovation; middle childhood; peer; postnatal; prenatal; prenatal exposure; prenatal health; prenatal influence; professional atmosphere; prospective; recruit; screening; sex; substance use; transmission process; uptake

Project Summary/Abstract The proposed research will clarify how heritable risks and prenatal and postnatal environments work together with hormonal changes to influence the development of risk for early substance use (SU) and related problems in adolescence. Understanding the development of SU problems is a vital health concern due to the economic costs of dealing with SU related injury, illness, death, crime, and lost productivity. Pathways and interactions by which genes, prenatal exposures, hormones, and key postnatal environmental factors influence the development of SU are not fully understood, in part because studies have not considered them together. The proposed research is innovative by using and expanding an existing prospective longitudinal adoption study, the Early Growth and Development Study (EGDS) to address the dearth of research combining heritable, prenatal, hormone, and postnatal influences. This proposal is timely, directly addressing PA-15-110, by using genetically informative approaches to expand research on the interplay of genetic and environmental factors in the genesis and course … of substance use disorders and comorbid conditions. The EGDS is a longitudinal study of children adopted at birth and their birth and adoptive parents (N = 561 linked triads). We propose to collect new data into early adolescence on SU milestones and related behaviors, and pubertal development. We will use existing and new data to: (SA1) estimate the unique contributions of heritable risk, prenatal, and postnatal environmental influences on trajectories of child behaviors from infancy to adolescence that increase risk for SU; (SA2) examine the mediating role of prenatal exposures for transmitting heritable influences on trajectories of behavioral risk for SU; (SA3) examine the mediating role of hormone development for transmitting heritable, prenatal and postnatal environmental influences on trajectories of behavioral risk for SU; and (SA4) Examine moderation of heritable, prenatal, and hormone influences by postnatal environments to elucidate the possible interactions among these factors in influencing child risk behaviors and early SU. This study will help to advance knowledge of the development of adolescent SU, to clarify which children are at greater risk for developing SU early in adolescence, and which influences are most salient for SU development given multiple other influences. This prospective, longitudinal, genetically-informed investigation using the EGDS is uniquely poised to achieve these aims, which are critical for gaining a more precise understanding of factors influencing the developmental course of SU that can be used to improve prevention efforts.

项目摘要/摘要 拟议的研究将阐明遗传风险，产前和产后环境如何 与马匹更改一起工作以影响早期主题的风险发展 在青少年中使用（SU）和相关问题。了解SU问题的发展 由于处理相关伤害，疾病， 死亡，犯罪和生产力失去。基因，产前基因的途径和相互作用 暴露，激素和关键产后环境因素影响 SU尚未完全理解，部分原因是研究没有将它们考虑在一起。 拟议的研究通过使用和扩展是创新的 现有的前瞻性纵向 收养研究，早期增长和发展研究（EGD） 死亡 研究结合了可遗传的，产前，骑马和产后影响。该提议是 及时，直接通过使用一般信息丰富的方法来扩展PA-15-110 研究遗传和环境因素在创世纪和过程中的相互作用… 物质使用障碍和合并症。 EGD是对儿童的纵向研究 出生时通过及其出生并收养父母（n = 561个连接的三合会）。我们建议 以SU里程碑和相关行为和青春期收集新数据 发展。我们将使用现有数据和新数据来：（SA1）估计 可遗传的风险，产前和产后环境对儿童行为轨迹的影响 从婴儿期到青少年，增加了SU的风险； （SA2）检查中介作用 产前暴露于传播对SU行为风险轨迹的遗传影响； （SA3）检查Horsene Development在传播可遗传的产前的中介作用 以及产后环境对SU行为风险轨迹的影响； （SA4） 检查可遗传，产前和马酮的节能受到产后环境的影响 阐明这些因素之间可能的相互作用，影响儿童风险行为和 早期的su。这项研究将有助于促进对青少年SU发展的了解，以 澄清哪些孩子在青少年早期有更大的风险，哪些儿童以及哪些儿童 鉴于其他多种影响，影响是SU开发最突出的。这 使用EGD的前瞻性，纵向，一般性的调查是独特的 要实现这些目标，这对于获得对因素的更精确理解至关重要 影响可用于改善预防努力的SU的发展过程。

项目成果

Inherited and Environmental Moderators of Mother-Child Behavioral Contingency and Contingent Negativity at 27 Months.

• DOI: 10.1016/j.infbeh.2020.101478
• 发表时间: 2020-11
• 期刊: Infant behavior & development
• 影响因子: 2.1
• 作者: Bray BA;Liu C;Roben CKP;Leve LD;Shaw DS;Ganiban JM;Reiss D;Natsuaki MN;Neiderhiser JM
• 通讯作者: Neiderhiser JM

The role of negative emotionality in the development of child executive function and language abilities from toddlerhood to first grade: An adoption study.

• DOI: 10.1037/dev0000972
• 发表时间: 2021-03
• 期刊: Developmental psychology
• 影响因子: 4
• 作者: Cioffi CC;Griffin AM;Natsuaki MN;Shaw DS;Reiss D;Ganiban JM;Neiderhiser JM;Leve LD
• 通讯作者: Leve LD

Do I Look Gawky? The Association between Pubertal Asynchrony and Peer Victimization.

• DOI: 10.3390/children8090794
• 发表时间: 2021-09-10
• 期刊: Children (Basel, Switzerland)
• 作者: Natsuaki MN;Stepanyan ST;Neiderhiser JM;Shaw DS;Ganiban JM;Reiss D;Leve LD
• 通讯作者: Leve LD

The Potential of Children's Rearing Environment to Overcome Genetic Propensity for Low Reading Achievement.

• DOI: 10.1111/mbe.12332
• 发表时间: 2022-11
• 期刊: MIND BRAIN AND EDUCATION
• 影响因子: 1.8
• 作者: Leve, Leslie D.;Harold, Gordon T.;Neiderhiser, Jenae M.;Natsuaki, Misaki N.;Shaw, Daniel S.;Ganiban, Jody M.;Reiss, David
• 通讯作者: Reiss, David

Does maternal warmth moderate longitudinal associations between infant attention control and children's inhibitory control?

• DOI: 10.1002/icd.2147
• 发表时间: 2020-01-01
• 期刊: INFANT AND CHILD DEVELOPMENT
• 影响因子: 2.2
• 作者: Cioffi, Camille C.;Leve, Leslie D.;Neiderhiser, Jenae M.
• 通讯作者: Neiderhiser, Jenae M.