Genes, prenatal drug exposure and postnatal environment: An Adoption Study

基因、产前药物暴露和产后环境：收养研究

• 批准号: 7266444
• 负责人: Jenae M. Neiderhiser
• 金额: $ 137.45万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-15 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7266444
• 关键词: Adolescent; Adoption; Adult; Age; Alcohol consumption; Alcohol or Other Drugs use; Alcoholism; Alcohols; Amphetamines; Attention; Behavior; Biological; Birth; Characteristics; Child; Child Behavior; Child Development; Child Rearing; Childhood; Cocaine; Cognitive; Collection; Conflict (Psychology); DNA; Dependence; Development; Developmental Delay Disorders; Disease; Disruption; Drug abuse; Drug usage; Environment; Environmental Risk Factor; Exposure to; Family; Family Process; Family Study; Fathers; Fetus; Fortune; Genes; Genetic; Genetic Research; Genetic Risk; Goals; Growth and Development function; High Prevalence; Individual; Inhalant dose form; Intervention; Knowledge; Link; Longitudinal Studies; Marijuana; Measurement; Measures; Mediating; Methods; Molecular Genetics; Mothers; Neurologic; Numbers; Parenting behavior; Parents; Participant; Pathway interactions; Pharmaceutical Preparations; Positioning Attribute; Postpartum Period; Pregnancy; Pregnancy Complications; Prevalence; Prevention; Preventive; Problem behavior; Public Health; Range; Rate; Recruitment Activity; Reporting; Research; Research Design; Research Personnel; Risk; Sampling; Smoke; Solutions; Specific qualifier value; Substance abuse problem; Symptoms; Tobacco; Toddler; Twin Multiple Birth; Variant; Woman; adopted child; day; design; drug abuse prevention; drug of abuse; early childhood; experience; fetal drug exposure; genetic risk factor; indexing; intergenerational; postnatal; prenatal; prenatal exposure; problem drinker; programs; prospective; research study; tool; transmission process; young adult

DESCRIPTION (provided by applicant): The proposed research study seeks to use and expand an existing prospective longitudinal adoption study, the Early Growth and Development Study (EGDS: R01HD42608) to better understand how genetic factors, prenatal drug exposure, and postnatal rearing environment operate together to influence toddler development, and ultimately, an individual's risk of later drug use. We propose to recruit 200 yoked adoption units (birth parents and adoptive families linked through the adopted child - approximately 866 individuals) and to capitalize on the existing 350 yokes recruited by the EGDS study. The 550 total yokes (approximately 2,382 individuals) will provide sufficient power to examine possible interactions among genes, prenatal drug exposure and postnatal rearing environment that EGDS was not designed to study. Using the same assessment strategy and measurement as EGDS, the new 200 yokes will be followed longitudinally and DNA will be collected from all participants in the full sample of 550 yokes. This expanded sample and longitudinal assessment, combined with the collection of DNA, enables the examination of the following specific aims: (SA1) Understanding how genetic risk for later drug use is expressed behaviorally in the toddler period; (SA2) Estimating prenatal exposure effects independent of genetic risk; (SA3) Estimating postnatal family environmental effects independent of genetic risk and prenatal exposure; and (SA4) Clarifying how genetic risk and prenatal exposure to drugs are moderated by postnatal family environment. Integrating the three possible mechanisms of the transmission of drug abuse to children - genetic, prenatal exposure and postnatal environment - has important potential for informing public health. Specifically, the proposed study is designed to disentangle the effects of genetic, prenatal and postnatal environmental factors on early child development and to examine interactions and correlations among these factors. This will help guide intervention efforts aimed at the prevention of drug abuse in children of drug-dependent or drug-abusing parents by identifying which postnatal family environmental factors have the most impact on ameliorating risk from genetic and prenatal exposure factors.

描述（由申请人提供）：拟议的研究旨在使用和扩展现有的前瞻性纵向收养研究，早期的增长和发展研究（EGD：R01HD42608），以更好地了解遗传因素，产前药物暴露和产后饲养环境如何共同影响托德勒的发展，以影响托德勒的发育，最终药物的使用，以及一个人的风险，是个人的风险。我们建议招募200个轭型收养单位（由收养儿童联系在一起的亲生父母和收养家庭 - 大约866个人），并利用EGDS研究招募的现有350个Yokes。 550个总koukes（约2,382个人）将提供足够的能力来检查基因之间可能的相互作用，产前药物暴露和产后饲养环境，而EGD并非旨在研究。使用与EGD相同的评估策略和测量，将纵向遵循新的200个houkes，并将在550个hokes的完整样本中收集所有参与者的DNA。这种扩展的样本和纵向评估与DNA的收集相结合，可以检查以下特定目的：（SA1）了解如何在幼儿时期行为表达后来的药物使用的遗传风险； （SA2）估计与遗传风险无关的产前暴露影响； （SA3）估计产后家庭环境的影响，与遗传风险和产前暴露无关； （SA4）阐明产后家庭环境如何调节遗传风险和产前暴露于药物。将吸毒向儿童传播的三种可能机制（遗传，产前暴露和产后环境）都具有为公共卫生提供信息的重要潜力。具体而言，拟议的研究旨在消除遗传，产前和产后环境因素对早期儿童发育的影响，并检查这些因素之间的相互作用和相关性。这将有助于指导旨在通过确定哪些产后家庭环境因素对遗传和产前暴露因素改善风险的影响最大的影响，以指导旨在预防药物依赖或滥用药物的父母的药物滥用的干预措施。