Tulane National Primate Research Center AIDS SPF Breeding Colony Maintenance

杜兰国家灵长类研究中心 AIDS SPF 繁殖群体维护

• 批准号: 10808529
• 负责人: RUDOLF Paul BOHM
• 金额: $ 50万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10808529
• 关键词: Accounting; Acquired Immunodeficiency Syndrome; Animals; Applied Research; Award; Basic Science; Behavioral; Biomedical Research; Breeding; COVID-19 pandemic; Caring; Clinical; Dedications; Equilibrium; Event; Foundations; Funding; Funding Agency; Future; Grant; Health; Herpesvirus 1; Housing; Human; Income; Infant; Infrastructure; Knowledge; Macaca; Macaca mulatta; Maintenance; Measures; Medical; Mission; Modeling; Parents; Pathogenesis; Personal Satisfaction; Primates; Privatization; Production; Research; Research Infrastructure; Research Personnel; Resources; Retroviridae; SIV; Sales; Scientific Advances and Accomplishments; Scientist; Simian T-lymphotropic virus 1; Testing; United States; United States National Institutes of Health; Weather; Well in self; base; co-infection; demographics; design; germ free condition; improved; microbicide; nonhuman primate; pre-exposure prophylaxis; programs; repaired; social; transmission process; vaccine development

PROJECT SUMMARY/ABSTRACT The Tulane National Primate Research Center (TNPRC) is one of seven National Primate Research Centers (NPRCs) sponsored by the National Institutes of Health. The Center is dedicated to providing the infrastructure and support for basic and applied research efforts to advance scientific knowledge and improve human and animal health and wellbeing. The TNPRC has one of the largest specific pathogen free (SPF) rhesus monkey breeding colonies in the United States. Over the past 5 years, this breeding colony produced between 595-957 infants annually and provided close to 2,000 animals for biomedical research programs, including those focused on AIDS. Award U42OD024282 funds the establishment and maintenance of the TNPRC SPF breeding colony to support AIDS research. The TNPRC AIDS research program is the largest at the Center, currently accounting for 61% of all grant funding and 67% of animals assigned to research at the TNPRC on an annual basis. The SPF breeding colony also provides rhesus macaques to affiliate investigators outside of the TNPRC for AIDS research. In 2022, 361 SPF rhesus macaques were requested for AIDS research by TNPRC and affiliate investigators. Of those, 312 have been allocated with the remainder awaiting assignment. Essentially all SPF rhesus monkeys utilized in AIDS research programs at the TNPRC are derived from the U42-supported TNPRC breeding colony. The TNPRC SPF program supports a variety of AIDS-related studies, including vaccine development, pre-exposure prophylaxis, microbicides, AIDS/TB coinfection, transmission pathogenesis, and cure research. Currently, there is high national demand for SPF macaques which requires the continued availability and enhancement of this resource. The proposed supplement to the U42 will be used to renovate an existing housing enclosure unit that has been decommissioned. The renovation will bring the facility to state-of-the-art status and incorporate additional measures to protect animals during inclement weather events. The housing enclosure renovation is within the scope of the of the parent award and does not overlap with any U42-funded projects. The benefits realized from this improvement will expand the TNPRC SPF rhesus macaque research infrastructure to assure these colonies are sustainable and able to provide high-quality research models well into the future.

项目概要/摘要 杜兰国家灵长类动物研究中心 (TNPRC) 是七个国家灵长类动物研究中心之一 （NPRC）由美国国立卫生研究院赞助。该中心致力于提供基础设施 支持基础和应用研究工作，以推进科学知识并提高人类和 动物健康和福祉。 TNPRC 拥有最大的无特定病原体 (SPF) 恒河猴之一 在美国繁殖的殖民地。在过去的 5 年里，这个繁殖群体生产了 595-957 只 每年为婴儿提供近 2,000 只动物用于生物医学研究项目，包括那些专注于生物医学研究项目的动物 关于艾滋病。 U42OD024282 奖资助 TNPRC SPF 繁殖群的建立和维护，以支持 艾滋病研究。 TNPRC 艾滋病研究项目是该中心最大的项目，目前占 61% 每年 67% 的赠款资金和 67% 的动物被分配到 TNPRC 进行研究。 SPF值 繁殖地还向 TNPRC 之外的艾滋病研究附属机构提供恒河猴 研究。 2022 年，TNPRC 及其附属机构要求 361 只 SPF 恒河猴用于艾滋病研究 调查人员。其中，312 已分配，其余等待分配。基本上都是SPF TNPRC 艾滋病研究项目中使用的恒河猴源自 U42 支持的 TNPRC 繁殖群体。 TNPRC SPF 计划支持各种与艾滋病相关的研究，包括疫苗 发展、暴露前预防、杀菌剂、艾滋病/结核病合并感染、传播发病机制和 治愈研究。目前，全国对 SPF 猕猴的需求量很大，需要持续的 该资源的可用性和增强。 拟议对 U42 的补充将用于翻新已被拆除的现有住房围护单元。 退役。此次翻修将使该设施达到最先进的状态，并纳入额外的设施 在恶劣天气事件期间保护动物的措施。房屋围护结构改造范围在 父奖项的范围，并且不与任何 U42 资助的项目重叠。实现的效益来自 这一改进将扩大 TNPRC SPF 恒河猴研究基础设施，以确保这些群体 是可持续的，能够为未来提供高质量的研究模型。