Tulane National Primate Research Center AIDS SPF Breeding Colony Maintenance

杜兰国家灵长类研究中心 AIDS SPF 繁殖群体维护

• 批准号: 10808529
• 负责人: RUDOLF Paul BOHM
• 金额: $ 50万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10808529
• 关键词: Accounting; Acquired Immunodeficiency Syndrome; Animals; Applied Research; Award; Basic Science; Behavioral; Biomedical Research; Breeding; COVID-19 pandemic; Caring; Clinical; Dedications; Equilibrium; Event; Foundations; Funding; Funding Agency; Future; Grant; Health; Herpesvirus 1; Housing; Human; Income; Infant; Infrastructure; Knowledge; Macaca; Macaca mulatta; Maintenance; Measures; Medical; Mission; Modeling; Parents; Pathogenesis; Personal Satisfaction; Primates; Privatization; Production; Research; Research Infrastructure; Research Personnel; Resources; Retroviridae; SIV; Sales; Scientific Advances and Accomplishments; Scientist; Simian T-lymphotropic virus 1; Testing; United States; United States National Institutes of Health; Weather; Well in self; base; co-infection; demographics; design; germ free condition; improved; microbicide; nonhuman primate; pre-exposure prophylaxis; programs; repaired; social; transmission process; vaccine development

PROJECT SUMMARY/ABSTRACT The Tulane National Primate Research Center (TNPRC) is one of seven National Primate Research Centers (NPRCs) sponsored by the National Institutes of Health. The Center is dedicated to providing the infrastructure and support for basic and applied research efforts to advance scientific knowledge and improve human and animal health and wellbeing. The TNPRC has one of the largest specific pathogen free (SPF) rhesus monkey breeding colonies in the United States. Over the past 5 years, this breeding colony produced between 595-957 infants annually and provided close to 2,000 animals for biomedical research programs, including those focused on AIDS. Award U42OD024282 funds the establishment and maintenance of the TNPRC SPF breeding colony to support AIDS research. The TNPRC AIDS research program is the largest at the Center, currently accounting for 61% of all grant funding and 67% of animals assigned to research at the TNPRC on an annual basis. The SPF breeding colony also provides rhesus macaques to affiliate investigators outside of the TNPRC for AIDS research. In 2022, 361 SPF rhesus macaques were requested for AIDS research by TNPRC and affiliate investigators. Of those, 312 have been allocated with the remainder awaiting assignment. Essentially all SPF rhesus monkeys utilized in AIDS research programs at the TNPRC are derived from the U42-supported TNPRC breeding colony. The TNPRC SPF program supports a variety of AIDS-related studies, including vaccine development, pre-exposure prophylaxis, microbicides, AIDS/TB coinfection, transmission pathogenesis, and cure research. Currently, there is high national demand for SPF macaques which requires the continued availability and enhancement of this resource. The proposed supplement to the U42 will be used to renovate an existing housing enclosure unit that has been decommissioned. The renovation will bring the facility to state-of-the-art status and incorporate additional measures to protect animals during inclement weather events. The housing enclosure renovation is within the scope of the of the parent award and does not overlap with any U42-funded projects. The benefits realized from this improvement will expand the TNPRC SPF rhesus macaque research infrastructure to assure these colonies are sustainable and able to provide high-quality research models well into the future.

项目摘要/摘要 杜兰国家灵长类动物研究中心（TNPRC）是七个国家灵长类动物研究中心之一 （NPRC）由美国国立卫生研究院赞助。该中心致力于提供基础设施 并支持基础和应用研究工作，以提高科学知识并改善人类和 动物健康和福祉。 TNPRC具有最大的特异性病原体（SPF）恒河猴之一 在美国繁殖菌落。在过去的5年中，这个繁殖菌落在595-957之间产生 每年婴儿，并为生物医学研究计划提供近2,000只动物，包括专注的动物 在艾滋病上。 授予U42OD024282为TNPRC SPF育种殖民地的建立和维护提供支持 艾滋病研究。 TNPRC AIDS研究计划是该中心最大的，目前占61％ 在所有赠款资金和67％的动物中，每年都会在TNPRC进行研究。 SPF 繁殖殖民地还为TNPRC以外的会员调查员提供了恒河猕猴的艾滋病 研究。在2022年，TNPRC和会员要求对361个SPF恒河猕猴进行艾滋病研究 调查人员。其中，将312分配给了等待任务的其余部分。本质上是所有SPF TNPRC的艾滋病研究计划中使用的恒河猴源自U42支持的TNPRC 繁殖殖民地。 TNPRC SPF计划支持各种与艾滋病有关的研究，包括疫苗 发育，暴露前预防，微生物，AIDS/TB共感染，传播发病机理和 治愈研究。目前，国家对SPF猕猴的需求很高，需要继续 该资源的可用性和增强。 拟议的U42补充剂将用于翻新现有的住房外壳单元 退役。翻新将使该设施达到最新状态，并纳入其他 在恶劣天气事件中保护动物的措施。住房外壳翻新在 父母奖的范围，并不与任何U42资助的项目重叠。从 这种改进将扩大TNPRC SPF恒河猕猴研究基础设施，以确保这些殖民地 具有可持续性，能够在未来提供高质量的研究模型。