Immune determinants of pediatric HIV/SIV reservoir establishment and maintenance

儿科 HIV/SIV 病毒库建立和维持的免疫决定因素

• 批准号: 10701468
• 负责人: Ann M Chahroudi
• 金额: $ 3.41万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10701468
• 关键词: Accountability; Accounting; Achievement; Acquired Immunodeficiency Syndrome; Adherence; Administrative Personnel; Advisory Committees; Animals; Annual Reports; Area; Bioinformatics; Cloud Computing; Collaborations; Communication; Communities; Complement; Computer software; Data; Decision Making; Dedications; Doctor of Philosophy; Documentation; Ensure; Environment; Feedback; Fostering; Funding; Funding Opportunities; Future; Goals; Guidelines; HIV-1; Immune; Infection; Infrastructure; Institution; Lead; Leadership; Maintenance; Manuscripts; Mentors; Monitor; Occupational activity of managing finances; Output; Play; Policies; Preparation; Production; Protocols documentation; Recording of previous events; Regulation; Reporting; Research; Research Personnel; Research Project Grants; Research Support; Resource Allocation; Resource Sharing; Resources; Role; SIV; Sampling; Schedule; Services; Site; Specimen; Strategic Planning; Structure; System; United States National Institutes of Health; Universities; Update; Work; biobank; cloud based; data communication; data dissemination; data management; data sharing; meetings; pediatric human immunodeficiency virus; programs; repository; symposium; synergism; Accountability; Accounting; Achievement; Acquired Immunodeficiency Syndrome; Adherence; Administrative Personnel; Advisory Committees; Animals; Annual Reports; Area; Bioinformatics; Cloud Computing; Collaborations; Communication; Communities; Complement; Computer software; Data; Decision Making; Dedications; Doctor of Philosophy; Documentation; Ensure; Environment; Feedback; Fostering; Funding; Funding Opportunities; Future; Goals; Guidelines; HIV-1; Immune; Infection; Infrastructure; Institution; Lead; Leadership; Maintenance; Manuscripts; Mentors; Monitor; Occupational activity of managing finances; Output; Play; Policies; Preparation; Production; Protocols documentation; Recording of previous events; Regulation; Reporting; Research; Research Personnel; Research Project Grants; Research Support; Resource Allocation; Resource Sharing; Resources; Role; SIV; Sampling; Schedule; Services; Site; Specimen; Strategic Planning; Structure; System; United States National Institutes of Health; Universities; Update; Work; biobank; cloud based; data communication; data dissemination; data management; data sharing; meetings; pediatric human immunodeficiency virus; programs; repository; symposium; synergism

ABSTRACT – Administrative Core This proposed Program’s overarching scientific goal is to understand the immune determinants of pediatric HIV reservoir establishment and maintenance. To ensure successful completion of the scientific Aims, the Administrative Core will coordinate oversight of all Program activities, create regulatory and NIH compliance documentation, and manage data and communication. The Core will serve as the Program hub for ensuring adherence to biorepository and institutional animal use policies and for coordinating the transfer of specimens and data. The Core will drive the Program’s focus on regular, consistent communication and will coordinate meetings to ensure extensive integration across Projects and Cores and to solicit feedback from the external Advisory Committee. The Administrative Core will also play a key role in ensuring the mentoring of early-stage investigators (ESIs) in Project Leadership roles, with support from the overall Program PI, Project Co-Leads, and the Emory Center for AIDS Research (CFAR). The Administrative Core will ensure fiscal accountability and proactively identify areas in which funds may need to be reallocated. This will be a key service of the Administrative Core that will help determine study directions in the later years of the project period. This function will be complemented by purposeful engagement of additional funding opportunities and strategic planning for future studies based on the results of the Program. The Administrative Core will also serve as the main contact for financial and data management with the Emory CFAR Cores that will be leveraged in this Program. Finally, the Core will contribute to Program synergy through the use of collaborative, cloud-based software that ensures the results generated across Projects are efficiently communicated and can be easily tracked and updated through the utilization of cloud-based computing outlined in the Bioinformatics Core. Regular maintenance of shared documents, experimental progress, and milestone achievement will allow for timely communication with the scientific community including the production of abstracts and manuscripts. The communication services provided by the Administrative Core will be critical in ensuring the objectives of each Research Project are met and that findings are disseminated to a broad public. By harnessing Emory’s existing research support environment and history of collaboration, this Core will ensure rapid Program start-up, including structure, efficiency, and expertise to support the proposed work.

摘要 - 行政核心 该计划的总体科学目标是了解小儿艾滋病毒的免疫确定因子 水库建立和维护。为了确保成功完成科学目标， 行政核心将协调所有计划活动，创建监管和NIH合规性 文档，管理数据和通信。核心将作为确保的程序中心 遵守生物座席和机构动物使用政策，并协调标本的转移 和数据。核心将推动该计划的重点放在常规，一致的沟通上，并将协调 会议以确保跨项目和核心的广泛集成，并征求外部的反馈 咨询委员会。行政核心也将在确保早期心理方面发挥关键作用 调查人员（ESI）在项目领导角色中担任调查人员，在PI总体计划联合领导者的整个计划的支持下， 以及艾米艾艾滋病研究中心（CFAR）。行政核心将确保财政责任 并主动确定可能需要重新分配资金的领域。这将是 行政核心将有助于确定项目期间后期的研究方向。这 功能将通过有目的的额外资金机会和策略来完成 根据该计划的结果计划未来的研究。行政核心也将作为 与Emory CFAR内核进行财务和数据管理的主要联系 程序。最后，核心将通过使用基于云的协作，有助于计划协同作用 确保跨项目产生的结果的软件有效地传达了，并且可以轻松地 通过在生物信息学核心中概述的基于云的计算的利用进行跟踪和更新。 定期维护共享文件，实验进度和里程碑成就将允许 及时与科学界的沟通，包括摘要和手稿的生产。这 行政核心提供的通信服务对于确保每个目标的目标至关重要 研究了研究项目，发现发现被传播给广泛的公众。通过利用埃默里的现有 研究支持环境和协作历史，该核心将确保快速计划启动， 包括结构，效率和专业知识，以支持拟议的工作。