Tulane National Primate Research Center AIDS SPF Breeding Colony Maintenance

杜兰国家灵长类研究中心 AIDS SPF 繁殖群体维护

• 批准号: 10252430
• 负责人: RUDOLF Paul BOHM
• 金额: $ 221.18万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10252430
• 关键词: 2019-nCoV; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Animal Testing; Animals; Award; Behavioral; Breeding; Caring; Clinical; Clinical Pathology; Communities; Cost Savings; Country; Databases; Disease; Emerging Communicable Diseases; Ensure; Equilibrium; Exclusion; Funding; Funding Agency; Funding Opportunities; Genetic; Genetic Variation; Goals; Grant; Human Resources; Income; Individual; Infectious Agent; Infrastructure; Investigation; Investments; Leadership; Link; Macaca mulatta; Maintenance; Measles virus; Medical; Monitor; Opportunistic Infections; Population; Population Genetics; Population Sizes; Primates; Procedures; Process; Production; Program Description; Records; Research; Research Personnel; Research Project Grants; Resources; Sales; Source; Specific qualifier value; Techniques; Testing; Time; Trypanosoma cruzi; United States; United States National Institutes of Health; Viral; Virus; Wages; Writing; animal colony; base; congenital infection; data management; demographics; experience; genetic analysis; genetic testing; germ free condition; immunosuppressed; nonhuman primate; offspring; programs; repaired; success; vaccine development

Project Summary/Abstract - Overall The Tulane National Primate Research Center (TNPRC) has one of the largest rhesus monkey breeding colonies in the United States. The objective of this application is to request funds for continued support and maintenance of the U42 supported SPF Indian-origin rhesus monkey breeding colony at the TNPRC. The specific aims address the components specified in the funding opportunity announcement (FOA) and are divided into the Overall program description, Husbandry and Management Core, Viral Testing Core, and MHC Genetic Typing Core. Program income and TNPRC funds will be used to support components of the program not covered by grant funds including: per diem for any colony animals in excess of the animals supported by this application, additional testing required for those animals, infrastructure repairs and improvements, veterinary clinical and pathology support, behavioral management support, and portions of the genetic testing. Specific Aims: Overall. To maintain the existing SPF colony and distribute available animals to the NIH funded HIV/AIDS research community. Husbandry and Management Core. To provide husbandry and veterinary care for the SPF breeding colony established in the existing U42 grant. This includes a robust program for clinical veterinary medical care and behavioral management. The colony has reached a mature self-sustaining status with ideal demographics to produce up to 105-150 animals available for assignment each year based on production and demand. Program income generated by the animal sales will be returned to an account for use in supporting the aims of the grant. Viral Testing Core. To assure the SPF status of the colony through continued viral testing of existing breeding colony animals and all offspring. Continue to expand characterization of the colony beyond the required 4 viruses to include agents such as measles virus, SARS-CoV-2, Trypanosoma cruzi, and other emerging infectious diseases that threaten nonhuman primates. MHC Genetic Typing Core. To continue genetic analysis and MHC typing of the colony and provide expanded genetic characterization through enhanced techniques.

项目摘要/摘要 - 总体 杜兰国家灵长类动物研究中心（TNPRC）是最大的恒河猴繁殖殖民地之一 在美国。本申请的目的是要求资金继续支持和维护 在TNPRC的U42支持SPF印度 - 印度恒河猴猴子繁殖殖民地。具体目标 解决资金机会公告（FOA）中指定的组件，并分为 总体计划描述，饲养和管理核心，病毒测试核心以及MHC遗传分类 核。计划收入和TNPRC资金将用于支持未涵盖的计划的组件 赠款资金，包括：对于任何殖民地动物的每日diem超过本应用支持的动物， 这些动物，基础设施维修和改进，兽医临床和 病理支持，行为管理支持以及基因检测的部分。 具体目的： 全面的。维持现有的SPF菌落并将可用动物分配给NIH资助的艾滋病毒/艾滋病 研究社区。 饲养和管理核心。为SPF繁殖殖民地提供饲养和兽医护理 在现有的U42赠款中建立。这包括针对临床兽医医疗和 行为管理。殖民地已经达到了成熟的自我维持地位，并具有理想的人口统计学 根据生产和需求，每年最多可用于分配的动物。程序 动物销售产生的收入将返回到支持赠款目标的帐户。 病毒测试核心。通过继续对现有育种的病毒测试来确保殖民地的SPF状态 殖民动物和所有后代。继续扩大殖民地的表征超出所需的4个病毒 包括麻疹病毒，SARS-COV-2，Cruzi锥虫和其他新兴感染性等药物 威胁非人类灵长类动物的疾病。 MHC遗传打字核心。继续菌落的遗传分析和MHC键入并提供扩展 通过增强技术的遗传表征。