Husbandry and Management Core

畜牧与管理核心

• 批准号: 10651841
• 负责人: RUDOLF Paul BOHM
• 金额: $ 174.79万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10651841
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Area; Award; Behavioral; Breeding; Caring; Clinical; Cost Savings; Databases; Decision Making; Diagnostic Services; Ensure; Equilibrium; Fostering; Funding; Funding Agency; Genetic; Goals; Grant; HIV/AIDS; Housing; Income; Individual; Infectious Agent; Laboratories; Link; Literature; Macaca; Macaca mulatta; Maintenance; Managed Care; Medical; Monitor; Pathology; Philosophy; Population; Preventive Medicine; Primates; Procedures; Process; Production; Recording of previous events; Records; Research; Research Personnel; Research Project Grants; Resources; Sales; Services; Source; Testing; Time; United States; United States National Institutes of Health; Viral; animal care; base; clinical care; data management; demographics; experience; germ free condition; improved; operation; programs; success

Project Summary/Abstract - Husbandry and Management Core The Tulane National Primate Research Center (TNPRC) has one of the largest rhesus monkey breeding colonies in the US. This resource has provided animals for NIH funded HIV/AIDS research projects for several decades and is a critical component of the Center's successful research program. Because over half of all research projects at TNPRC are initiated by Affiliate (non-TNPRC) investigators, this resource is essential to the success of many NIH-funded investigators throughout the US. The TNPRC has a long history of deriving, developing, and managing large macaque breeding colonies. The experience derived from many years of colony management is a significant contributing factor to the successful establishment of the U42 SPF colony and achieving the goal of converting the entire TNPRC rhesus monkey colony to SPF status. The TNPRC has focused on a philosophy of continuous improvement, which is fostered by the use of evidence, derived from observation, controlled scientific study, and the literature to drive decision making. This philosophy is employed in many areas of the program including housing, behavioral management, husbandry practices, nursery rearing, preventive medicine, and clinical veterinary care. The objective of this application is to request funds for continued support and maintenance of this SPF rhesus monkey breeding colony at the TNPRC. The maintenance of the U42 breeding colony requires the integration of many aspects of the animal care program at TNPRC including veterinary care, behavioral management, genetic monitoring, and viral testing to ensure SPF status of the colony. This section describes the husbandry and management of the colony and focuses on daily care operations, behavioral management, and clinical care. The Specific Aim of this core is to provide husbandry and veterinary care for the SPF breeding colony established in the existing U42 grant. This includes robust programs for clinical care and behavioral management. The colony has reached a mature status of approximately 1400 animals (SPF4 n=1269; eSPF n=131) with ideal demographics to produce up to 150 animals per year for research assignment based on production and demand. Program Income generated by the sale of animals will be returned to an account for use in supporting the aims of the grant.

项目摘要/摘要 - 畜牧和管理核心 杜兰国家灵长类动物研究中心 (TNPRC) 拥有最大的恒河猴繁殖群之一 在美国。几十年来，该资源为 NIH 资助的艾滋病毒/艾滋病研究项目提供了动物 是该中心成功研究计划的重要组成部分。因为超过一半的研究 TNPRC 的项目由附属机构（非 TNPRC）研究人员发起，该资源对于 美国许多 NIH 资助的研究人员取得了成功。 TNPRC 拥有悠久的历史， 开发和管理大型猕猴繁殖群。多年殖民地经验 管理是 U42 SPF 群体成功建立的重要因素 实现将整个 TNPRC 恒河猴群体转变为 SPF 状态的目标。 TNPRC 有 专注于持续改进的理念，这是通过使用证据来培育的，这些证据源自 观察、受控科学研究和推动决策的文献。这一哲学被运用 在该计划的许多领域，包括住房、行为管理、畜牧实践、保育、 预防医学和临床兽医护理。此申请的目的是请求资金 继续支持和维护 TNPRC 的 SPF 恒河猴繁殖群。这 U42 繁殖群体的维护需要整合动物护理计划的许多方面 TNPRC 包括兽医护理、行为管理、基因监测和病毒检测，以确保 SPF 殖民地的状况。本节介绍蜂群的饲养和管理，重点介绍日常 护理操作、行为管理和临床护理。 该核心的具体目标是为建立的 SPF 繁殖群提供畜牧和兽医护理 在现有的 U42 补助金中。这包括强大的临床护理和行为管理计划。殖民地 大约 1400 只动物（SPF4 n=1269；eSPF n=131）已达到成熟状态，具有理想的 根据生产和需求，每年生产多达 150 只动物用于研究任务。 出售动物产生的计划收入将退回到一个账户，用于支持该目标 的补助金。