SPECIFIC PATHOGEN FREE RHESUS MONKEY COLONY FOR AIDS RESEARCH

用于艾滋病研究的无特定病原体恒河猴群体

• 批准号: 8358041
• 负责人: RUDOLF Paul BOHM
• 金额: $ 5.78万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358041
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Behavioral; Blood; Bone Marrow; Breeding; Censuses; Data; Derivation procedure; Feces; Funding; Grant; Macaca mulatta; Methods; National Center for Research Resources; Primates; Principal Investigator; Production; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; SIV; Saliva; Simian T-lymphotropic virus 1; Source; Specific Pathogen Frees; Tissues; United States National Institutes of Health; Virus; cost; germ free condition; meetings; minimally invasive; programs; social group

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Background: Two grants (U24, U42) provide funding for derivation of the AIDS SPF colony. Methods: Initially animals were derived from the TNPRC conventional breeding colony. Animals are negative for SIV, STLV-1, SRV, and B-virus. All animals from the AIDS SPF colonies are limited to assignment to AIDS research projects. The census of the colony is approximately 2001, which meets projections. Seventy-one of the animals are assigned to the expanded SPF program. Results/Discussion: In 2010, 215 SPF rhesus were made available for assignment to affiliate and core investigators. In addition, piggybacked use of animals in the breeding colony occurred. Tissues, including blood, feces, saliva, and bone marrow, were provided to investigators to support their research programs. Behavioral/observational data were also collected to support research and management programs. All piggyback use of animals is noninvasive or minimally invasive and allows animals to remain in their social groups with no impact to production.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 背景：两项赠款（U24，U42）为衍生的AIDS SPF菌落提供了资金。 方法：最初是源自TNPRC常规育种菌落的动物。 动物对SIV，STLV-1，SRV和B病毒为阴性。 AIDS SPF殖民地的所有动物都仅限于艾滋病研究项目的分配。 殖民地的人口普查大约在2001年，符合预测。将71只动物分配到扩展的SPF计划。 结果/讨论：在2010年，215个SPF恒河猴可供分配给会员和核心研究人员。 此外，发生了动物在繁殖菌落中的使用。 向研究人员提供了包括血液，粪便，唾液和骨髓在内的组织，以支持其研究计划。 还收集了行为/观察数据以支持研究和管理计划。所有对动物的背包使用都是无创或微创的，允许动物留在其社会群体中，对生产没有影响。