Core 3: Biocontainment Research Support Services Core

核心 3：生物防护研究支持服务核心

基本信息

批准号：
10791950
负责人：
Colin S. Duckett
金额：
$ 102.95万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-18 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10791950
关键词：
2019-nCoV Animal Experimentation Animal Model Animals Antibodies Antigens Applied Research Area Award Basic Science Biological Assay Biological Markers Cell Separation Cells Characteristics Chikungunya virus Clinical Collaborations Communities Containment Cytomegalovirus Development Diagnostic Disease Ebola Ensure Environment Equipment and supply inventories Evaluation Fee-for-Service Plans Ferrets Flow Cytometry Francisella tularensis Funding Goals HIV Hamsters Home Human Immune Immunologic Markers Immunologic Monitoring Immunology Immunology procedure Infection Influenza Infrastructure Institution Laboratories Laboratory Animal Models Malaria Microbiology Mission Modeling Mus Mycobacterium tuberculosis National Institute of Allergy and Infectious Disease Performance Pharmaceutical Preparations Productivity Publications Recording of previous events Research Research Personnel Research Support Resource Development Safety Sampling Secure Services Societies Sorting Source Therapeutic Training Training Support Translational Research Tuberculosis United States National Institutes of Health Universities Vaccines Variant Viral Virus Workforce Development Yellow fever virus Yersinia pestis ZIKA biocontainment facility biodefense cytokine disease diagnostic experience global health laboratory experience mouse model novel novel therapeutics novel vaccines novel virus operation pathogen pathogenic virus programs virology

项目摘要

ABSTRACT- Biocontainment Research Support Services Core (Core 3) The central mission of the Duke RBL is to support the basic and translational research necessary to develop drugs, diagnostics, and vaccines for emerging/reemerging infections and biodefense. Support through this award will allow us to expand our existing services to refine our small animal models programs, thus providing a wider range of services offered to the research community. It will also render our virology program more effective, particularly through the development of a direct workflow from our clinical laboratories at Duke, in addition to relying on third party sources, particularly for rapidly emerging viral variants. Thirdly, we will broaden our range of immunological assays performed in our BSL-3 suites, such as live cell flow sorting and rapid evaluation of cytokine and biomarker profiles. The goals of this Biocontainment Research Support Services Core (Core 3) are to 1) establish, maintain, and provide small animal challenge models with BSL-3 pathogens through the Duke RBL Animal Models Research Support Services; 2) maintain and provide quality- controlled virus inventory of Select Agents and pathogens requiring BSL-3 conditions through the Duke RBL Virology Research Support Services; and 3) provide comprehensive immune monitoring at BSL-3 via humoral, cellular, and biomarker analysis through the Duke RBL Immunology and Flow Cytometry Research Support Services. Implementation of these three Aims will allow us to expand the capabilities and services that we can offer not only to the Duke community, but also to our neighboring institutions and the national RBL network.

摘要 - 生物威力研究支持服务核心（核心3） RBL杜克大学的核心使命是支持开发必要的基本和转化研究用于新兴/重新出现的感染和生物性的药物，诊断和疫苗。通过此支持奖项将使我们能够扩大现有服务以完善我们的小动物模型计划，从而提供为研究社区提供的各种服务。它还将使我们的病毒学计划更多有效，特别是通过开发我们在杜克大学的临床实验室的直接工作流程除了依靠第三方来源，特别是迅速出现的病毒变异。第三，我们会的扩大我们在BSL-3套件中执行的免疫学测定范围，例如活细胞流动和快速评估细胞因子和生物标志物谱。这项生物培养研究支持的目标服务核心（核心3）是1）建立，维护和提供小动物挑战模型通过Duke RBL动物模型研究支持服务的病原体； 2）维护和提供质量 - 通过Duke RBL需要BSL-3条件的精选药物和病原体的受控病毒清单病毒学研究支持服务； 3）通过体液提供BSL-3的全面免疫监测，通过Duke RBL免疫学和流式细胞仪研究支持的细胞和生物标志物分析服务。实施这三个目标将使我们能够扩大我们可以的能力和服务不仅向杜克社区提供提供，还向我们的邻近机构和国家RBL网络提供。