Core 1: Facility Management, Maintenance and Operations Core

核心 1：设施管理、维护和运营核心

基本信息

批准号：
10791948
负责人：
Colin S. Duckett
金额：
$ 93.32万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-18 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10791948
关键词：
2019-nCoV Alphavirus Animal Model Applied Research Area Basic Science Biological Biological Assay Cellular Assay Certification Communicable Diseases Containment Contractor Coronavirus Cytomegalovirus Dedications Diagnostic Disease Outbreaks Ebola Elements Ensure Equipment Equipment and supply inventories Event Failure Fee-for-Service Plans Ferrets Flavivirus Funding Goals HIV Hamsters Hemagglutination Home Human Immune response Immunology In Vitro Infection Infectious Diseases Research Influenza Laboratories Leadership Longevity Maintenance Malaria Microbiology Mission Molecular Mus Mycobacterium tuberculosis National Institute of Allergy and Infectious Disease Oryctolagus cuniculus Pharmaceutical Preparations Poxviridae Process Proteins Protocols documentation Publications Readiness Research Research Design Research Personnel Research Support Resource Development Safety Schedule Secure Serology Services Societies System Therapeutic Time Training Training Support Translational Research Trust Tuberculosis United States National Institutes of Health Universities Vaccines Vendor Viral Load result Virus Workforce Development Yersinia pestis ZIKA animal imaging biodefense biosecurity design experience future pandemic global health immune reconstitution improved in vivo influenzavirus instrumentation laboratory facility multiplex assay novel vaccines operation pathogen programs repaired risk minimization square foot virology

项目摘要

ABSTRACT- Facility Management, Maintenance and Operations Core (Core 1) To serve the primary mission of the Duke RBL, it is imperative that the facility itself operates to the highest operational standards. The overall goal of this Aim is to ensure that we can maintain reliable and uninterrupted facility functionality. To achieve this goal, we focus on several critical elements: the facility must be safely and effectively operated through a functional and seamless management process, inculcating a culture of safety that permeates throughout the entire organization; the systems that are vital to the operation of the facility must be well-maintained, and where appropriate the scheduled replacement of key systems must be planned prior to any likely systems failure (i.e. before the end of the lifespan of the system or equipment). Finally, and consistent with the aforementioned culture of safety, it is essential that facility meets or exceeds all of the regulatory standards that are required for all of our systems and equipment. The goals of this Facility Management, Maintenance and Operations Core (Core 1) are to 1) provide expert management and oversight of the BSL-3 space; 2) ensure proper preventative maintenance of all critical systems; and 3) ensure continuous compliance with all applicable regulatory standards. This Core is foundational to the safe and effective operation of the Duke RBL core, and as with all programs dedicated to managing and minimizing risk, embodies a culture of iterative improvement and the highest of operating standards.

摘要 - 设施管理，维护和操作核心（核心1）为了服务公爵RBL的主要任务，该设施本身必须运作最高操作标准。这个目标的总体目标是确保我们可以保持可靠和不间断设施功能。为了实现这一目标，我们专注于几个关键要素：该设施必须安全，并且通过功能和无缝的管理过程有效运行，灌输安全文化在整个组织中渗透；对设施运行至关重要的系统必须保持维护良好，必须在适当的情况对于任何可能的系统故障（即系统或设备的寿命结束之前）。最后，然后与上述安全文化一致，设施必须达到或超过所有我们所有系统和设备所需的监管标准。该设施的目标管理，维护和操作核心（核心1）是1）提供专家管理和监督 BSL-3空间； 2）确保对所有关键系统的适当预防性维护； 3）确保连续遵守所有适用的监管标准。这个核心是安全的基础公爵RBL核心的有效操作，以及所有致力于管理和最小化风险的计划，体现了迭代改进和最高运营标准的文化。