Core 2: BSL-3 Practices Core

核心 2：BSL-3 实践核心

基本信息

批准号：
10791949
负责人：
Scott Alderman
金额：
$ 92.03万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-18 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10791949
关键词：
2019-nCoV Alphavirus Animal Model Applied Research Area Basic Science Biological Biological Assay Cellular Assay Certification Containment Coronavirus Cytomegalovirus Dangerousness Dedications Diagnostic Ebola Education Ensure Environment Equipment and supply inventories Fee-for-Service Plans Ferrets Flavivirus Funding Grant HIV Hamsters Heart Hemagglutination Home Human Human Resources Immune response Immunology In Vitro Individual Infection Influenza Laboratories Location Malaria Microbiology Mission Molecular Mus Mycobacterium tuberculosis National Institute of Allergy and Infectious Disease Oryctolagus cuniculus Performance Pharmaceutical Preparations Poxviridae Procedures Proteins Protocols documentation Publications Readiness Research Research Design Research Personnel Research Support Resource Development Route Safety Secure Security Serology Services Site Societies Therapeutic Time Training Training Activity Training Programs Training Support Translational Research Tuberculosis United States National Institutes of Health Universities Vaccines Viral Load result Virus Work Workforce Development Yersinia pestis ZIKA animal imaging biodefense biosecurity design emerging pathogen experience future pandemic global health hands on instruction immune reconstitution improved in vivo influenzavirus instrumentation lens member multiplex assay novel vaccines operation pathogen programs square foot supportive environment theories virology

2019-nCoV Alphavirus Animal Model Applied Research Area Basic Science Biological Biological Assay Cellular Assay Certification Containment Coronavirus Cytomegalovirus Dangerousness Dedications Diagnostic Ebola Education Ensure Environment Equipment and supply inventories Fee-for-Service Plans Ferrets Flavivirus Funding Grant HIV Hamsters Heart Hemagglutination Home Human Human Resources Immune response Immunology In Vitro Individual Infection Influenza Laboratories Location Malaria Microbiology Mission Molecular Mus Mycobacterium tuberculosis National Institute of Allergy and Infectious Disease Oryctolagus cuniculus Performance Pharmaceutical Preparations Poxviridae Procedures Proteins Protocols documentation Publications Readiness Research Research Design Research Personnel Research Support Resource Development Route Safety Secure Security Serology Services Site Societies Therapeutic Time Training Training Activity Training Programs Training Support Translational Research Tuberculosis United States National Institutes of Health Universities Vaccines Viral Load result Virus Work Workforce Development Yersinia pestis ZIKA animal imaging biodefense biosecurity design emerging pathogen experience future pandemic global health hands on instruction immune reconstitution improved in vivo influenzavirus instrumentation lens member multiplex assay novel vaccines operation pathogen programs square foot supportive environment theories virology

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项目摘要

ABSTRACT – BSL-3 Practices Core (Core 2) The central mission of the Regional Biocontainment Laboratory Network is to provide a location and an environment in which groundbreaking research on potentially dangerous pathogens can be performed safely. As anyone with the responsibility of managing a leading BSL-3/ABSL-3 facility such as the Duke RBL will attest, it is critical to imbue a culture of safety in which all individuals seek continuous improvement and refinement of best practices. This culture of constant improvement must be sustained through the inevitable turnover of staff that occurs in any long-standing facility, and while it is difficult to codify, we pride ourselves on providing a cordial and supportive environment in which ideas for improvement by all members of the team are welcomed. Viewed through this lens, the practices and Standard Operating Procedures (SOPs) that define the Duke RBL are continuously being refined and improved. Since the opening of the facility in 2007, the Duke RBL has led the field with a world class safety team dedicated to providing safe, secure, and compliant research through managing SOPs, conducting a rigorous training program, and assessments of performance. Support from this grant will allow for the further enhancement of these programs through warm-readiness and additional dedicated safety staff. Specific aims for this proposal are to 1) establish and maintain procedures for safe and compliant research at BSL-3/ABSL-3; 2) provide biosafety theory education with hands-on instruction for all personnel entering BSL-3/ABSL-3 for work with Select Agents; and 3) ensure continuous compliance with established procedures by conducting routing biosafety/security audits and drills. The ability to maintain and expand these robust safety programs to account for novel pathogens is critical for investigators to adequately prepare for the next pandemic.

摘要 - BSL-3实践核心（核心2）区域生物疗养实验室网络的核心任务是提供一个位置和一个可以安全地进行对潜在危险病原体的开创性研究的环境。正如任何有责任管理领先的BSL-3/ABSL-3设施（例如RBL）的人一样证明，至关重要的是，所有个人都寻求持续改进和最佳实践的完善。这种不断改进的文化必须通过不可避免的在任何长期存在的设施中发生的员工的营业额，虽然很难编纂，但我们以自己为荣提供一个亲切而支持的环境，团队所有成员的改进想法是欢迎。通过此镜头观看，定义的实践和标准操作程序（SOP）公爵RBL正在不断得到完善和改进。自2007年设施开业以来 RBL领导了该领域的世界一流安全团队，致力于提供安全，安全且合规通过管理SOP，进行严格的培训计划以及对绩效评估进行研究。这笔赠款的支持将允许通过热烈的准备和进一步增强这些计划额外的专用安全人员。该提案的具体目的是1）建立和维护程序 BSL-3/ABSL-3的安全和合规研究； 2）通过动手指导提供生物安全理论教育对于所有进入BSL-3/ABSL-3的人员，与精选代理商一起工作； 3）确保连续合规通过进行既定程序，通过进行路由生物安全/安全审核和演习。维护能力并扩大这些强大的安全计划以解释新的病原体对于研究人员至关重要充分准备下一个大流行。