Physiological Genomics of Critical Illness and Injury

危重疾病和损伤的生理基因组学

• 批准号: 7371082
• 负责人: J PERREN COBB
• 金额: $ 15.5万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7371082
• 关键词: Address; Biological; Biological Markers; Cessation of life; Collaborations; Complex; Computational Biology; Consensus; Critical Illness; Education; Ethics; Experimental Designs; Face; Funding; Gene Expression; Genetic Polymorphism; Genomics; Goals; Human; Infection; Inflammatory; Injury; Investigation; Methods; Morbidity - disease rate; Organ failure; Physiological; Polymorphism Analysis; Privacy; Proteomics; Research; Research Personnel; Resources; Single Nucleotide Polymorphism; Syndrome; System; Systems Analysis; Technology; Trauma; functional genomics; gene function; high throughput technology; interest; novel; patient safety; programs; response; skills; symposium; therapeutic target; tool

DESCRIPTION (provided by applicant): Organ failure syndromes that cause substantial morbidity and death often complicate critical illness due to severe infection or traumatic injury. Recent advances in computational biology and high-throughput technologies (e.g. microarrays, highly parallel single nucleotide polymorphism (SNP) analysis, and proteomics) have generated considerable interest in developing a more global understanding of complex biological systems. The application of these technologies to critical illness offers the potential to define maladaptive programs of gene expression induced by infection, trauma or other inflammatory triggers and to detect biomarkers and genetic polymorphisms that are associated with these responses. These tools also provide a means to discover novel gene function and to identify potential therapeutic targets. Investigators that plan to use genomic and proteomic approaches to study critical illness and injury are presented with major challenges regarding the unique demands that these methods place on resources, experimental design, and analysis. Furthermore, investigations in this setting face unique requirements related to patient safety, vulnerability, and privacy as well as other ethical considerations specific to performing genomic research. The Functional Genomics of Critical Illness and Injury Symposium has been held annually for the past two years to address these needs (www.cc.nih.gov/ccmd/Symposium/). This application seeks funding for the Physiological Genomics of Critical Illness and Injury Symposium (April 21-22, 2005), the goal of which is to bring together those with the diverse skills sets necessary to apply genomics and systems analysis to the study of critical illness and injury. The objectives are three-fold: education, consensus, and collaboration. Importantly, there is no other venue by which this group of investigators might meet to discuss the application of genomic technology, ethics, and human values to the study of critical illness and injury.

描述（由申请人提供）：导致大量发病和死亡的器官衰竭综合征通常会因严重感染或外伤而使危重疾病复杂化。计算生物学和高通量技术（例如微阵列、高度并行单核苷酸多态性（SNP）分析和蛋白质组学）的最新进展引起了人们对复杂生物系统的更全面理解的极大兴趣。这些技术在危重疾病中的应用提供了定义由感染、创伤或其他炎症触发因素诱导的基因表达适应不良程序的潜力，并检测与这些反应相关的生物标志物和遗传多态性。这些工具还提供了发现新基因功能和识别潜在治疗靶点的方法。计划使用基因组和蛋白质组学方法来研究危重疾病和损伤的研究人员面临着这些方法对资源、实验设计和分析的独特要求的重大挑战。此外，在这种情况下的研究面临与患者相关的独特要求 安全、脆弱性和隐私以及执行基因组特定的其他道德考虑因素 研究。过去两年每年都会举办危重疾病和损伤功能基因组学研讨会来满足这些需求（www.cc.nih.gov/ccmd/Symposium/）。本申请为危重疾病和损伤生理基因组学研讨会（2005 年 4 月 21 日至 22 日）寻求资助，其目标是汇集具有将基因组学和系统分析应用于危重疾病研究所需的各种技能的人员和伤害。目标有三个：教育、共识和协作。重要的是，没有其他场所可以让这组研究人员会面来讨论基因组技术、伦理学和人类价值观在危重疾病和损伤研究中的应用。