US CRITICAL ILLNESS AND INJURY TRAILS GROUP

美国危重疾病和伤害追踪小组

• 批准号: 8043774
• 负责人: J PERREN COBB
• 金额: $ 10.21万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8043774
• 关键词: Acute; Address; Adult; Caring; Cause of Death; Centers for Disease Control and Prevention (U.S.); Clinical; Clinical Protocols; Clinical Trials; Clinical Trials Design; Collaborations; Communication; Critical Care; Critical Illness; Data; Development; Disease; Funding; Goals; Grant; Group Meetings; Injury; Institutes; Measures; NIH Program Announcements; Organ; Outcome; Patients; Population; Preparation; Privacy; Publishing; Reporting; Research; Science; Sorting - Cell Movement; System; Testing; Training; United States National Institutes of Health; Writing; base; disability; ethical legal social implication; evidence base; improved; injured; meetings; programs; success

DESCRIPTION (provided by applicant): Critical illness and injury are leading causes of death and disability world- wide. Despite our nation's expertise and the imperative to improve outcomes for the critically ill and injured, the US does not have a federally-funded critical care research network for adults. Instead, funding for critical illness and injury research is divided along organ-based or disease-based lines across federal agencies, including but not limited to institutes and offices within the NIH, CDC, and DOD, among others. Moreover, there is little interaction between many existing NIH large-scale critical illness and injury research programs. As a result, there has been a call for better communication, synergy, and funding efficiency at a national level, thereby improving the breadth and quality of acute care research. Indeed, the emergence of a systems-based approach for the study of critical illness and injury demands this sort of scientific and inter-agency interaction, as reflected by recent NIH trans-Institute program announcements. To address these needs, this grant will create a US Critical Illness and Injury Trials Group (USCIITG) meeting. The Group will facilitate collaboration among experts with the goal of promoting clinical trials in the critically ill or injured. This grant will not fund clinical trials per se, but rather promote at quarterly meetings the development of evidence-based clinical protocols and the subsequent preparation of applications for funding to test specific hypotheses. The specific aims include the following: 1) Establish an inclusive, nationwide network of experts to review published data, establish national priorities, vet hypotheses, write clinical protocols, and generate pilot data; 2) Promote interaction and synergy across established programs, both academic and non-academic, to improve the robustness of clinical trails and test hypotheses in a US population; 3) Provide a venue to educate and train clinicians of all backgrounds in the science of trial design, conduct, analysis, and reporting; 4) Insure patient protection and privacy by addressing the ethical, legal, and social implications (ELSI) of research in the specialized circumstance of critical illness or injury. The USCIITG will be governed by steering and organizational committees. The USCIITG will convene yearly meetings at the NIH Bethesda campus, with interval quarterly meetings held in conjunction with the annual meetings of critical illness and injury professional societies.Lay Summary This grant will create a US Critical Illness and Injury Trials Group meeting. The Group will facilitate collaboration among experts with the goal of promoting clinical trials in the field of critical illness and injury. The success of the Group will be measured by the number of new grants funded to test hypotheses in clinical trails in the critically ill or injured.

描述（由申请人提供）：重大疾病和伤害是全世界死亡和残疾的主要原因。尽管我们国家拥有专业知识，并且迫切需要改善危重病和伤员的治疗结果，但美国没有联邦资助的成人重症监护研究网络。相反，重大疾病和损伤研究的资金按照基于器官或基于疾病的方式在联邦机构之间分配，包括但不限于美国国立卫生研究院、疾病预防控制中心和国防部等机构和办公室。此外，NIH 现有的许多大型危重疾病和损伤研究项目之间几乎没有互动。因此，人们呼吁在国家层面加强沟通、协同和资金效率，从而提高急症护理研究的广度和质量。事实上，正如最近 NIH 跨研究所项目公告所反映的那样，用于研究危重疾病和损伤的基于系统的方法的出现需要这种科学和机构间的互动。为了满足这些需求，这笔赠款将成立美国危重疾病和伤害试验小组 (USCIITG) 会议。该小组将促进专家之间的合作，以促进危重病或伤者的临床试验。这笔赠款本身不会资助临床试验，而是在季度会议上促进循证临床方案的制定以及随后准备用于测试特定假设的资助申请。具体目标包括以下内容： 1）建立一个包容性的全国性专家网络，以审查已发布的数据，确定国家优先事项，审查假设，编写临床方案并生成试点数据； 2) 促进已建立的学术和非学术项目之间的互动和协同作用，以提高美国人群中临床试验和测试假设的稳健性； 3) 提供一个场所，对各种背景的临床医生进行试验设计、实施、分析和报告科学方面的教育和培训； 4) 通过解决危重疾病或伤害的特殊情况下的研究的伦理、法律和社会影响 (ELSI)，确保患者保护和隐私。 USCIITG 将由指导委员会和组织委员会管理。 USCIITG 将在 NIH 贝塞斯达校区召开年度会议，每季度会议与重大疾病和伤害专业协会年会结合举行。 这笔赠款将创建美国危重疾病和伤害试验小组会议。该集团将促进专家之间的合作，以促进重大疾病和伤害领域的临床试验。该小组的成功将通过资助用于在危重病或受伤者的临床试验中测试假设的新拨款的数量来衡量。