Impact of Omega-3 Intake During Pregnancy on Maternal Stress and Infant Outcome
怀孕期间 Omega-3 摄入量对母亲压力和婴儿结局的影响
基本信息
- 批准号:7660952
- 负责人:
- 金额:$ 19万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-07-06 至 2011-06-30
- 项目状态:已结题
- 来源:
- 关键词:AffectAnxietyAreaAttentionBehaviorBehavioralBrainCell membraneChildChild Mental HealthChronic stressCognitiveDevelopmentDietDocosahexaenoic AcidsEmotionalEmotionsErythrocytesEssential Fatty AcidsEventExposure toFamilyFatty AcidsFetusFish OilsFishesFundingGlucocorticoidsGoalsHormonalHormonesHumanHydrocortisoneInfantInfant DevelopmentInfant HealthInflammatory ResponseIntakeInterventionLaboratoriesLifeMeasuresMediatingMental HealthMothersNational Institute of Mental HealthNeuronsNorepinephrineNutritionalOmega-3 Fatty AcidsOutcomePatient Self-ReportPerinatal ExposurePhysiologicalPilot ProjectsPlacebosPolyunsaturated Fatty AcidsPovertyPregnancyPregnant WomenPreventionPsychological StressPsychosocial StressRandomizedRandomized Controlled TrialsRecoveryRegulationReportingResearchResearch DesignResearch PersonnelRiskRodentRoleSignal TransductionSourceStimulusStressSupplementationSystemTemperamentTestingTimeTranslational ResearchTrier Social Stress TestWomanWorkbasebiological adaptation to stressbiological systemsclinical carecognitive functiondepressiondietary supplementsemotion regulationenvironmental stressorexperiencehealth disparityinfant outcomeinfant temperamentinner cityinnovationmaternal stressmemberneurotransmitter uptakenonhuman primatenutritionoffspringprenatal stressprogramspsychological stressorpublic health relevancereceptor functionresponsestemstressortransmission process
项目摘要
DESCRIPTION (provided by applicant): Pregnant women living in poverty often experience chronic stress, and consequently higher levels of stress hormones. In utero exposure to high levels of stress hormones can negatively affect the developing fetus and later, the infant's capacity for emotion and behavioral regulation. In this proposal we describe a developing program of research designed to reduce the negative impact of prenatal stress on infant health and development via nutritional supplementation of docosahexaenoic acid (DHA) during pregnancy. DHA is a long-chain polyunsaturated fatty acid member of the omega-3 fatty acid family. DHA is found in its highest concentrations in neural cell membranes, affecting receptor function, neurotransmitter uptake, and signal transmission. There is growing evidence that low levels of dietary DHA intake are associated with suboptimal response to stress and that DHA supplementation can modulate stress response. Aims: The goals of the proposed study are to explore whether DHA supplementation during pregnancy is associated with 1) a reduction in maternal perceived stress during pregnancy; 2) a more modulated maternal cortisol response to a stress stimulus during pregnancy, and 3) more optimal regulation of emotion and behavior in the infant. Approach: Sixty-five pregnant women living in inner-city poverty, who consume less than two servings of fish per week, will be randomly assigned to receive 450 mg/daily of DHA or placebo beginning at 16-20 weeks gestation through the end of pregnancy. Perceived stress, pregnancy related stress, stressful life events, anxiety, and depression will be assessed at baseline and at 24, 30, and 36 weeks of pregnancy and at 4 months post-partum. DHA levels will be assessed at baseline and at 36 weeks of pregnancy. Cortisol response to the Trier Social Stress Test will be measured at baseline, 24, and 30 weeks. At 4 months post-partum infant temperament, cognitive development and stress reactivity will be assessed in the laboratory. Investigators: This proposal stems from an NIMH R21 Translational Science Network on prenatal stress and mental health outcomes in the offspring. Three members of that network, Drs. Keenan, Carter, and Glover, are all funded investigators in the area of prenatal stress and child mental health, which is a prioritized area of exploratory research that could directly impact clinical care. They are collaborating on the present application. Innovation: This will be the first randomized controlled study of the effect of DHA supplementation on stress response in pregnant women living in inner-city poverty, and the first study of maternal DHA supplementation on emotion and stress regulation in their infants. Relevance: If DHA supplementation is associated with reductions in perceived stress, more modulated maternal cortisol response to stress, and more optimal emotional and behavioral regulation in the infant, even within the context inner-city poverty, then a comprehensive program of research on the mechanisms by which these associations evolve and the potential for broad-based prevention of poor developmental outcomes among children born to women living in poverty can be launched. PUBLIC HEALTH RELEVANCE: This will be the first study of the effect of essential fatty acid supplementation in pregnant women living in inner-city poverty on the stress response system during pregnancy. If essential fatty acid supplementation is associated with reductions in the experience of stress, more modulated hormonal response to stress, and more optimal regulation of emotion and attention in the infant, even within the context inner-city poverty, then a comprehensive program of research on the role of nutrition on stress during pregnancy can be launched. This study may be the first step toward broad-based prevention of poor developmental outcomes among children born to women living in poverty.
描述(由申请人提供):生活在贫困中的孕妇经常会经历慢性压力,因此压力激素水平更高。在子宫内暴露于高水平的压力激素可能会对发育中的胎儿产生负面影响,后来是婴儿的情绪和行为调节能力。在这项建议中,我们描述了一项发展的研究计划,旨在通过补充二十二碳六烯酸(DHA)在怀孕期间对婴儿健康和发育的负面影响。 DHA是Omega-3脂肪酸家族的长链多不饱和脂肪酸成员。 DHA在神经细胞膜中的最高浓度发现,影响受体功能,神经递质摄取和信号传播。越来越多的证据表明,低水平的饮食DHA摄入量与对压力的次级反应有关,并且补充DHA可以调节压力反应。目的:拟议的研究的目标是探索怀孕期间补充DHA是否与1)孕妇在怀孕期间的感知压力减轻有关; 2)在怀孕期间对应激刺激的更调制的母体皮质醇反应,以及3)对婴儿的情绪和行为的最佳调节。方法:居住在城市内部贫困中的六十五名孕妇每周消耗少于两份鱼,将随机分配每天接受450 mg/每天的DHA或安慰剂,从16-20周的妊娠期开始,直到怀孕结束。将在基线,怀孕的24、30和36周以及后4个月的24、30和36周时评估所感知的压力,与妊娠相关的压力,压力性生活事件,焦虑和抑郁症。 DHA水平将在基线和怀孕36周时进行评估。在基线,24和30周时,将测量对Trier社会压力测试的皮质醇反应。在产后婴儿的4个月后,将在实验室评估认知发展和压力反应性。调查人员:该提案源于NIMH R21转化科学网络有关后代的产前压力和心理健康成果的转化科学网络。该网络的三个成员,博士。基南(Keenan),卡特(Carter)和格洛弗(Glover)都是产前压力和儿童心理健康领域的资助研究人员,这是探索性研究的优先领域,可能直接影响临床护理。他们正在与本应用程序进行合作。创新:这将是对居住在城市内部贫困中孕妇的压力反应影响的第一个随机对照研究,也是对婴儿对情绪和婴儿压力调节的首次研究。相关性:如果补充DHA与减轻感知压力的减轻,对压力的孕妇皮质醇的反应更加适应,以及在婴儿中,更最佳的情绪和行为调节,即使在上下文中的内部贫困中,也是对这些机制的全面研究计划,那么这些机制的研究计划是对这些联系的贫困发展的潜力,并且对贫穷的发展妇女的潜在贫穷的妇女源于贫穷的妇女中的贫穷犬只的潜力。公共卫生相关性:这将是对居住在城市内部贫困中的孕妇的必需脂肪酸补充对应激反应系统怀孕期间的首次研究。如果补充基本脂肪酸与压力的减少,对压力的荷尔蒙反应更加调制以及婴儿对婴儿的情绪和注意力的更佳调节有关,即使在背景下的城市内部贫困中,则可以发射有关营养在妊娠期间营养作用的全面研究计划。这项研究可能是迈向基于贫困妇女出生的儿童发展不良发展结果的第一步。
项目成果
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Kathryn Elizabeth Keenan其他文献
Kathryn Elizabeth Keenan的其他文献
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