Developmental comorbidity of pain and depression in preadolescent girls

青春期前女孩疼痛和抑郁的发育合并症

• 批准号: 7816818
• 负责人: Kathryn Elizabeth Keenan
• 金额: $ 7.8万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7816818
• 关键词: 9 year old; Address; Adolescence; Adolescent; Adrenal Glands; Adult; Age; Area; Behavioral; Biological; Biological Assay; Characteristics; Childhood; Comorbidity; Data; Depressed mood; Depressive disorder; Development; Disease; Dissociation; Distress; Emotional; Etiology; Female; Functional disorder; Funding; Goals; Hydrocortisone; Hypothalamic structure; Impairment; Individual; Individual Differences; Laboratories; Link; Longitudinal Studies; Measurement; Measures; Medical; Mental Depression; Modeling; Mothers; NIH Program Announcements; National Institute of Mental Health; Pain; Pain Disorder; Pain Research; Pain Threshold; Pain management; Parents; Pathway interactions; Pattern; Perception; Pituitary Gland; Play; Population; Productivity; Puberty; Public Health; Publishing; Request for Applications; Research; Resources; Risk; Role; Saliva; Sampling; Secure; Services; Stimulus; System; Testing; Variant; biobehavior; biological adaptation to stress; boys; chronic pain; clinically significant; cost; depressive symptoms; experience; functional disability; girls; high risk; hypothalamic-pituitary-adrenal axis; indexing; innovation; neural circuit; noradrenergic; preadolescence; programs; prospective; public health relevance; response; sex; stressor

DESCRIPTION (provided by applicant): The revised application is in response to PA-06-543, "Mechanisms, Models, Measurement, & Management in Pain Research (R03)." Consistent with this program announcement, we aim to test hypotheses about the developmental pathways to comorbid pain and depressive disorders in females. Clinically significant pain disorders are markedly more common in individuals with depression, particularly in females who are more likely to experience both pain and depression from adolescence on. This is an issue of considerable public health significance, as depressed individuals who experience high levels of pain experience marked distress and functional impairment and are frequent consumers of medical services. Aims: The specific aims for this application are to address the following questions: 1) Are individual differences in behavioral and biological response to a pain stressor concurrently associated with depression and impairment at ages 10 and 12 and does this association grow stronger as puberty progresses; 2) Do specific patterns of behavioral and biological response to a pain stressor explain variance in depression and functional impairment at ages 10 and 12; and 3) Are individual differences in response to a pain stressor at ages 10 and 12 prospectively associated with individual differences in depression and impairment at ages 11 and 13, after controlling for depression and impairment at ages 10 and 12? Approach: In the context of a longitudinal study currently funded by NIMH, Preadolescence precursors to depression in girls (R01 MH66167), 232 nine-year old girls are being assessed annually for a period of 5 years. Data are collected from both the girls and their mothers. We have embedded a pain stimulus into the longitudinal study, the cold pressor task (CPT), which was administered at age 10 and is planned for administration at age 12. We have collected saliva in response to the CPT age 10 and plan to collect samples again at age 12. There are no funds for assaying cortisol from the saliva or for conducting analyses on pain response in the parent R01. The purpose of this application for an R03 is to secure funding for testing hypotheses about the developmental phenomenology of comorbid pain and depression in females, an aim that was not included in the parent R01 study. Innovation: This will be the first study to explore the developmental interface between pain and depression using behavioral and biological responses to a controlled pain stimulus and clinically meaningful measures of depressive symptoms beginning in childhood. PUBLIC HEALTH RELEVANCE: Clinically significant pain disorders are much more common in individuals with depression, particularly in females who are more likely to experience both pain and depression from adolescence on. Given the impact of co-occurring pain and depression on public health for females especially, probing the developmental unfolding of the relations between depression and pain in girls is an important area of research. This will be the first study to explore the developmental interface between pain and depression using behavioral and biological responses to a controlled pain stimulus and clinically meaningful measures of depressive symptoms beginning in childhood.

描述（由申请人提供）：修订后的应用是对PA-06-543的响应，“疼痛研究中的机制，模型，测量和管理（R03）”。与此计划公告一致，我们旨在检验有关女性合并性疼痛和抑郁症的发育途径的假设。在抑郁症患者中，临床上显着的疼痛障碍更为常见，尤其是在女性中更有可能从青春期开始疼痛和抑郁的女性。这是一个相当大的公共卫生意义的问题，因为那些经历了高水平的疼痛经历的沮丧的人明显遇险和功能障碍，并且经常是医疗服务的消费者。目的：该应用的具体目的是解决以下问题：1）对疼痛压力源的行为和生物学反应的个体差异是在10岁和12岁时与抑郁症和抑郁症相关的疼痛压力，并且这种关联会随着青春期的进展而变得更加强大； 2）对疼痛应激源的行为和生物反应的特定模式解释了抑郁症的方差和10岁和12岁的功能障碍； 3）在控制10和12岁的抑郁症和障碍之后，对10和12岁的疼痛压力源的响应中的个体差异是否与抑郁症和障碍的个体差异有关？方法：在当前由NIMH资助的纵向研究的背景下，女孩抑郁症的前体前体（R01 MH66167），每年对232个9岁女孩进行5年评估。数据是从女孩及其母亲那里收集的。我们已经将疼痛刺激嵌入了纵向研究中，冷式压托任务（CPT）是在10岁时进行的，并计划在12岁时进行管理。我们已经收集了唾液，以响应10岁的CPT，并计划在12岁时再次收集样本。没有用于从Saliva中分析皮质醇的资金，以恢复痛苦或进行分析的痛苦。该R03应用程序的目的是确保资金用于测试女性合并症疼痛和抑郁症的发育现象学的假设，这一目的不包括在父母R01研究中。创新：这将是第一次使用对受控疼痛刺激的行为和生物学反应来探索疼痛和抑郁症之间发育界面的研究，从儿童期开始对抑郁症状的抑郁症状进行有意义的措施。公共卫生相关性：临床上显着的疼痛障碍在抑郁症患者中更为普遍，尤其是在女性中更有可能从青春期开始疼痛和抑郁的女性。鉴于同时发生的疼痛和抑郁症对女性的影响，尤其是对女性的公共卫生的影响，探讨了女孩抑郁与疼痛之间关系的发展是一个重要的研究领域。这将是第一次使用对受控疼痛刺激的行为和生物学反应探索疼痛和抑郁症之间发育界面的研究，从儿童期开始对抑郁症状的抑郁症状进行有意义的措施。