Extreme temperatures and the aging brain in three nationally representative surveys

三项全国代表性调查中的极端温度和大脑老化

• 批准号: 10730463
• 负责人: Sara Adar
• 金额: $ 40.63万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10730463
• 关键词: Acceleration; Acclimatization; Adult; Affect; Aging; Air Pollution; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Attention; Biology; Cardiovascular Diseases; Chronic; Chronic Disease; Climate; Cognition; Cognitive; Communities; Country; Data; Dementia; Development; Documentation; Educational workshop; Elderly; Environment; Environmental Risk Factor; Evaluation; Event; Exposure to; Frequencies; Future; Green space; Health; Health and Retirement Study; Heating; Housing; Human; India; Individual; International; Intervention; Learning; Link; Low income; Memory; Mental Health; Methodology; Methods; Mexico; Microclimate; Nerve Degeneration; Nervous System Trauma; Persons; Physical environment; Play; Population; Predisposition; Prevalence; Problem Solving; Reporting; Research; Research Infrastructure; Research Personnel; Resource Sharing; Risk Factors; Role; Science; Scientist; Sleep disturbances; Social isolation; Source; Surveys; Temperature; Time; Training Activity; Travel; United States; Variant; Work; aging brain; analytical method; brain health; climate change; climate impact; cognitive function; cohort; coping mechanism; dementia risk; disability; experience; extreme heat; extreme temperature; health data; high risk; innovation; insight; interest; modifiable risk; novel; prevent; reading comprehension; research study; webinar

ABSTRACT Currently, only 40% of dementia can be explained by known risk factors and individual-level interventions have been largely ineffective in preventing illness. As a result, there is increasing attention on aspects of the physical environment that may have a role in poor cognitive functioning in later life and the development of Alzheimer’s disease and related dementias (ADRD). While air pollution is a known risk factor for dementia, the impacts of other aspects of the natural environment on brain health are less well studied. Notably, extreme temperatures have been linked to increased thermal discomfort, disrupted sleep, poorer mental health, as well as accelerated neuron degeneration and nervous system damage, yet there is very little research on the impacts of temperature on the aging brain. This project will leverage the substantial aging research infrastructure of the Gateway to Global Aging Data project to promote research on the impacts of extreme temperatures on cognition and dementia. By conducting analyses in surveys from the United States, Mexico, and India, we will help to establish methodology and guidance documents that can be used by the larger Health and Retirement Study and its International Network of Studies (HRS-INS) research community and advance the science on extreme temperatures and health. Specifically, our aims are to: 1) Quantify the associations of exposures to extreme heat and cold over long time frames with cognitive function and dementia prevalence in older adults; 2) Investigate the degree to which extreme heat and cold over short time frames are associated with cognitive function in older adults and evaluate sources of susceptibility; and 3) Generate guidance documentation for climate research in the Gateway and share these resources with the broader research community. This proposed research is highly innovative because it examines both short- and long- term exposure to extreme temperatures on cognition and dementia prevalence within the Gateway project, leveraging intra- and international sources of variation for added power and better generalizability to an economically diverse set of nations. Additionally, given the richness of data in the Gateway project, we will be able to newly examine sources of susceptibility at the individual level to better understand how extreme temperatures impact cognitive health and the subpopulations most affected. Lastly, we will help to establish methodology and guidance documents that can be used by the larger HRS-INS research community and advance the science on extreme temperatures and health.

抽象的 目前，只有40％的痴呆症可以通过已知危险因素来解释 我们在预防疾病方面基本上无效。结果，人们越来越关注 物理环境可能在以后的生活和发展中发挥作用 阿尔茨海默氏病和相关痴呆症（ADRD）。空气污染是痴呆症的已知危险因素，但 自然环境其他方面对脑部健康的影响较差。值得注意的是，极端 温度与增加的热不适，睡眠中断，精神健康较差有关 随着神经元变性和神经系统损害的加速，几乎没有研究 温度对衰老大脑的影响。该项目将利用大量的老龄化研究 通往全球老化数据项目的基础设施，以促进对极端影响的研究 认知和痴呆的温度。通过在美国墨西哥的调查中进行分析 和印度，我们将帮助建立大型较大的方法和指导文件 健康与退休研究及其国际研究网络（HRS-INS）研究界和 在极端温度和健康方面提高科学。具体来说，我们的目标是：1）量化 长期与认知功能和痴呆症的极端热和寒冷的暴露与极端热和寒冷的关联 老年人患病率； 2）研究短时间内极热和寒冷的程度 与老年人的认知功能相关，并评估易感性的来源； 3）生成 网关中气候研究的指导文档，并与更广泛的资源共享这些资源 研究社区。这项拟议的研究具有很高的创新性，因为它研究了短期和长期的 在门户项目内对认知和痴呆症患病率的极端温度暴露的期限， 利用内部和国际差异来源来增加功率，并更好地推广 经济多样化的国家。此外，鉴于网关项目中的数据丰富，我们将是 有可能在个人层面新检查敏感性来源，以更好地了解极端 温度会影响认知健康和受影响最大的亚群。最后，我们将帮助建立 较大的HRS INS研究社区可以使用的方法和指导文档以及 在极端温度和健康方面提高科学。