Extreme temperatures and the aging brain in three nationally representative surveys

三项全国代表性调查中的极端温度和大脑老化

• 批准号: 10730463
• 负责人: Sara Adar
• 金额: $ 40.63万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10730463
• 关键词: Acceleration; Acclimatization; Adult; Affect; Aging; Air Pollution; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Attention; Biology; Cardiovascular Diseases; Chronic; Chronic Disease; Climate; Cognition; Cognitive; Communities; Country; Data; Dementia; Development; Documentation; Educational workshop; Elderly; Environment; Environmental Risk Factor; Evaluation; Event; Exposure to; Frequencies; Future; Green space; Health; Health and Retirement Study; Heating; Housing; Human; India; Individual; International; Intervention; Learning; Link; Low income; Memory; Mental Health; Methodology; Methods; Mexico; Microclimate; Nerve Degeneration; Nervous System Trauma; Persons; Physical environment; Play; Population; Predisposition; Prevalence; Problem Solving; Reporting; Research; Research Infrastructure; Research Personnel; Resource Sharing; Risk Factors; Role; Science; Scientist; Sleep disturbances; Social isolation; Source; Surveys; Temperature; Time; Training Activity; Travel; United States; Variant; Work; aging brain; analytical method; brain health; climate change; climate impact; cognitive function; cohort; coping mechanism; dementia risk; disability; experience; extreme heat; extreme temperature; health data; high risk; innovation; insight; interest; modifiable risk; novel; prevent; reading comprehension; research study; webinar

ABSTRACT Currently, only 40% of dementia can be explained by known risk factors and individual-level interventions have been largely ineffective in preventing illness. As a result, there is increasing attention on aspects of the physical environment that may have a role in poor cognitive functioning in later life and the development of Alzheimer’s disease and related dementias (ADRD). While air pollution is a known risk factor for dementia, the impacts of other aspects of the natural environment on brain health are less well studied. Notably, extreme temperatures have been linked to increased thermal discomfort, disrupted sleep, poorer mental health, as well as accelerated neuron degeneration and nervous system damage, yet there is very little research on the impacts of temperature on the aging brain. This project will leverage the substantial aging research infrastructure of the Gateway to Global Aging Data project to promote research on the impacts of extreme temperatures on cognition and dementia. By conducting analyses in surveys from the United States, Mexico, and India, we will help to establish methodology and guidance documents that can be used by the larger Health and Retirement Study and its International Network of Studies (HRS-INS) research community and advance the science on extreme temperatures and health. Specifically, our aims are to: 1) Quantify the associations of exposures to extreme heat and cold over long time frames with cognitive function and dementia prevalence in older adults; 2) Investigate the degree to which extreme heat and cold over short time frames are associated with cognitive function in older adults and evaluate sources of susceptibility; and 3) Generate guidance documentation for climate research in the Gateway and share these resources with the broader research community. This proposed research is highly innovative because it examines both short- and long- term exposure to extreme temperatures on cognition and dementia prevalence within the Gateway project, leveraging intra- and international sources of variation for added power and better generalizability to an economically diverse set of nations. Additionally, given the richness of data in the Gateway project, we will be able to newly examine sources of susceptibility at the individual level to better understand how extreme temperatures impact cognitive health and the subpopulations most affected. Lastly, we will help to establish methodology and guidance documents that can be used by the larger HRS-INS research community and advance the science on extreme temperatures and health.

抽象的 目前，只有 40% 的痴呆症可以用已知的风险因素来解释，并且个体层面的干预措施已经 在预防疾病方面基本上无效，因此，人们越来越关注这些方面。 物理环境可能会导致晚年认知功能不良和智力发展 阿尔茨海默病和相关痴呆症 (ADRD) 虽然空气污染是痴呆症的一个已知危险因素，但 值得注意的是，自然环境其他方面对大脑健康的影响还没有得到充分研究。 温度也与增加热不适、睡眠中断、心理健康状况不佳有关 加速神经退化和神经系统损伤，但对此的研究却很少 该项目将利用大量的衰老研究。 全球老龄化数据门户项目的基础设施，以促进对极端气候影响的研究 通过对美国、墨西哥的调查进行分析， 和印度，我们将帮助建立可供更大的国家使用的方法和指导文件 健康与退休研究及其国际研究网络 (HRS-INS) 研究社区和 具体来说，我们的目标是： 1）量化 长期暴露于极热和极冷环境与认知功能和痴呆症的关系 老年人中的患病率；2) 调查短时间内极端炎热和寒冷的程度 与老年人的认知功能相关并评估易感性来源；3) 生成； 网关中气候研究的指导文件，并与更广泛的领域共享这些资源 这项拟议的研究具有高度创新性，因为它同时考察了短期和长期研究。 Gateway 项目中长期暴露于极端温度对认知和痴呆患病率的影响， 利用内部和国际变异源来增加力量和更好的普遍性 此外，鉴于网关项目中数据的丰富性，我们将 能够在个体层面上重新检查易感性来源，以更好地了解极端程度 最后，我们将帮助确定温度影响认知健康和受影响最严重的亚人群。 可供更大的 HRS-INS 研究团体使用的方法和指导文件，以及 推进有关极端温度和健康的科学。