Expanding the Gateway Research Infrastructure on Exposome Studies for the Health and Retirement Study and the Harmonized Cognitive Assessment Protocol International Network of Studies

扩大健康与退休研究暴露组研究的门户研究基础设施和统一认知评估协议 国际研究网络

• 批准号: 10661375
• 负责人: Sara Adar
• 金额: $ 245.65万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10661375
• 关键词: Affect; Age; Aging; Air; Air Pollutants; Air Pollution; Alzheimer' s Disease; Alzheimer' s disease related dementia; American; Americas; Area; Birth; Caribbean region; Characteristics; Chile; China; Cognition; Cognitive aging; Cohort Studies; Computers; Country; Data; Data Analyses; Data Files; Data Set; Databases; Dementia; Dominican Republic; Education; Educational workshop; Elderly; England; Ensure; Environment; Environmental Exposure; Europe; Evolution; Exposure to; Funding; Goals; Health; Health and Retirement Study; India; Individual; Infrastructure; International; Investments; Ireland; Laws; Learning; Letters; Life; Light; Link; Literature; Location; Long-Term Care; Longitudinal Studies; Longitudinal cohort study; Measures; Metadata; Mexico; Monitor; National Institute on Aging; Neuropsychological Tests; Nitrogen Dioxide; Northern Ireland; Ozone; Parents; Participant; Particulate Matter; Persons; Plants; Policies; Pollution; Privacy; Protocols documentation; Puerto Rico; Questionnaires; Research; Research Infrastructure; Research Personnel; Resolution; Resources; Respondent; Retirement; Risk Factors; Role; Sampling; Schools; Series; Statistical Models; Surveys; Temperature; Time; Training; Training Activity; United States; Variant; Water; Work; World Bank; base; behavioral outcome; caregiving; cognitive function; cognitive testing; data access; data enclave; data harmonization; data interoperability; dementia risk; demographics; fine particles; health data; human mortality; improved; longitudinal analysis; novel; open data; parent project; sex; stem; webinar

Abstract Building resources to produce widely accessible, (re)usable, and interoperable data from high-value, publicly- funded cohort studies is one of the National Institute on Aging’s key milestones for the Alzheimer’s disease (AD) and AD-related dementia (ADRD) research implementation. The Gateway to Global Aging Data (Gateway) is a data platform developed to harmonize and disseminate data from the Health and Retirement Study and its international network of studies (HRS-INS) to facilitate longitudinal analyses on aging across 47 countries. Our overarching goal is to expand the Gateway by incorporating additional environmental characteristics that might influence cognition and the onset and progression of AD/ADRD, collecting and documenting historical policy changes in education, harmonizing newly available metadata from two Harmonized Cognitive Assessment Protocol (HCAP) studies in the Northern Ireland and the Caribbean America (Puerto Rico and Dominican Republic), and preparing harmonized analytical datafiles for the Gateway Data Enclave. Integrating environmental characteristics that influence health and behavioral outcomes has been an important aim of the Gateway. In our parent project, we have or will estimate exposure to fine particulate matter (PM2.5) at a 1-km resolution for the U.S., England, Ireland, India, China, Mexico, and Chile, using the satellite data together with ground monitor data. These data are already linked to the HRS, the English Longitudinal Study of Ageing (ELSA), and the Longitudinal Aging Study in India (LASI). Taking it a step further, we aim to bring in additional open data sources on environmental measures that might influence health and cognition, such as nitrogen dioxide (NO2), ozone (O3), ambient air temperature, light pollution, and access to green and blue spaces. Motivated by the rapid evolution of policies affecting older people across the world, we launched the Gateway Policy Explorer Series. This series captures historic policies in place at the time of surveys covered in the Gateway. Our work has so far focused on retirement and long-term care policies, and we aim to expand this work by compiling historical changes in compulsory schooling laws and policies aimed at affecting the quality of education for the countries with HCAP data and add this policy area to the Gateway’s Policy Explorer. We will also integrate additional contextual data on education, such as country-and-year specific learning-adjusted years of schooling from the World Bank, and other relevant contextual variables, such as country, birth year, sex, and age-specific mortality from the Human Mortality Database. For rapid dissemination, we have built the Gateway Data Enclave, a new remote-access, NIA-sponsored Health & Aging Data (HaAD) enclave, for researchers to access data from their own computers. We propose to construct an exposome analysis datafile for pooled cross-country analysis of late-life cognition and dementia and their risk factors, which includes linked environmental exposure measures and historic policy changes in education. We will also create new training materials and guidance documents and organize a series of webinars and an in-person user workshop.

抽象的 建立资源以产生可广泛访问，可用和可互操作的数据，来自高价值，公开的数据 资助的队列研究是美国国家老年人的主要里程碑研究所（AD） 与广告相关的痴呆症（ADRD）研究实现。 一个数据平台，旨在协调和传播健康和退休研究的数据，并且是ISTES 国际研究网络（HRS-INS）促进了47个国家的衰老 总体目标是通过结合可能的其他环境特征来扩展网关 影响认知以及AD/ADRD的发作和发展，收集和记录历史政策 教育的变化，通过两个统一认知评估来协调新近可用的元数据 北爱尔兰和加勒比海的协议（HCAP）研究（波多黎各和多米尼加 共和国，并为网关数据飞地进行了预先统一的分析文件。 环境特征thalth和行为结果一直是其中的重要目的。 网关。 与卫星数据一起使用美国，英语，爱尔兰，爱尔兰，印度，中国，墨西哥和智利的决议。 地面监视器数据是与HRS相关的小动物，英语纵向研究（ELSA） 以及印度的纵向老化（Lasi）。 可能影响健康和认知的环境措施的来源，例如二氧化氮（NO2） 臭氧（O3），环境空气温度，光询问，并进入绿色和蓝色空间。 影响全球老年人的政策的演变，我们启动了Gateway Policy Explorer系列。 该系列在门户涵盖的调查时捕获了位置。 专注于退休和长期护理政策，我们旨在通过汇编历史来扩大这项工作。 强制性学校法律和政策的变化，旨在深情的国家教育质量 使用HCAP数据，并将此策略添加到网关的策略资源管理器中。 有关教育的上下文数据，例如从您的国家和特定的特定学习调整后的教育年份 世界银行和其他背景变异性，例如国家，出生年，性别和特定年龄的死亡率 从人类死亡率数据库中 远程访问，由NIA赞助的健康与老化数据（HAAD）飞地，供研究人员访问数据 我们的计算机。 晚期肠结构认知和痴呆症以及风险因素，其中包括链接的环境暴露措施 以及教育的历史性政策变化。 并组织一系列网络研讨会和一个面对面的用户研讨会。