CSHL Course on Yeast Genetics and Genomics

CSHL 酵母遗传学和基因组学课程

• 批准号: 7630493
• 负责人: DAVID J. STEWART
• 金额: $ 5.04万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7630493
• 关键词: Alleles; Animal Model; Area; Arts; Bacteriology; Bacteriophages; Basic Science; Biochemical; Biochemistry; Biological; Biology; Botany; Cellular biology; Classification; Collaborations; Communities; Complement; Complex; Detection; Development; Educational Curriculum; Educational process of instructing; Educational workshop; Ensure; Evolution; Faculty; Genes; Genetic; Genetic Engineering; Genetic Recombination; Genome; Genomics; Grant; Hand; Immersion Investigative Technique; In Situ; Insertional Mutagenesis; Institutes; Instruction; Knock-out; Laboratories; Learning; Long Island; Mathematics; Methodology; Methods; Modeling; Molecular; Molecular Biology; Molecular Genetics; Monitor; Mutation; Names; Nature; Organelles; Organism; Participant; Philosophy; Physiology; Policies; Postdoctoral Fellow; Principal Investigator; Process; Protein Biochemistry; Proteins; Proteomics; Reagent; Recording of previous events; Recruitment Activity; Regulation; Research; Research Methodology; Research Personnel; Research Training; Resources; Retirement; Role; Rosa; Saccharomyces cerevisiae; Science; Scientist; Screening procedure; Series; Side; Structure; Students; System; Techniques; Technology; Testing; Time; Training; Update; Vertebral column; Visit; Work; Yeasts; Zoology; bacterial genetics; base; biological research; biological systems; design; experience; functional genomics; gene function; genetic analysis; graduate student; high standard; innovation; instructor; investigator training; knockout gene; lecturer; lectures; loss of function mutation; mathematical model; meetings; novel strategies; programs; research study; response; stem; tool; yeast genetics; yeast two hybrid system

DESCRIPTION (provided by applicant): The Cold Spring Harbor Laboratory Yeast Genetics and Genomics Course proposes to continue with a long tradition of serving a critical role in the training of investigators new to the use of S. cerevisiae for biological research. The recent title change reflects a greater emphasis on familiarizing participants with the use of the latest techniques in genomics and proteomics. This three-week highly intensive course is designed to make each student proficient in the fundamentals of yeast genetics which then establishes the conceptual backbone for the more sophisticated methods that are covered as the course progresses. The laboratory experiments are broken into twelve multi-part sections that cover a variety of topics including: 1. Fundamentals of working with yeast; 2. Introduction to yeast molecular biology; 3. Genetic and physical interaction analysis; and 4. Genomics. The experimental portion of the course is complemented by daily theoretical lectures by the instructors chosen for their proven expertise in the system and a world-class seminar series from renowned investigators that utilize the yeast system. As a result every student is exposed to the underlying principles of the methods they are being taught and their state-of-the-art application by the experts in the field. The course has a well-established reputation for, and seeks to continue, serving a diverse community of biologists that include scientists from disparate backgrounds such as evolutionary biology, quantitative biology, as well as biologists working in other systems that can prove a clear benefit from the utilization of yeast, given the large number of resources available for functional genomic studies in this model organism. In addition, educators that seek to incorporate yeast approaches in undergraduate courses are occasional students in the course. Although the general organization of the course is intended to remain the same from year to year, there is a natural evolution in content as the broad field of yeast biology and genomics changes; as instructors are replaced (~1 per year) new expertise is added to the course and the latest technologies and approaches are incorporated into the curriculum by the new instructors. Since at least two instructors remain from year to year, this evolution does not come at the sacrifice of continuity.

描述（由申请人提供）：冷泉港实验室酵母遗传学和基因组学课程建议继续延续悠久的传统，在培训新近使用酿酒酵母进行生物学研究的研究人员方面发挥关键作用。最近的标题变化反映出更加重视让参与者熟悉基因组学和蛋白质组学最新技术的使用。这门为期三周的高度强化课程旨在使每个学生精通酵母遗传学的基础知识，然后为课程进展中涵盖的更复杂的方法奠定概念基础。实验室实验分为十二个多部分部分，涵盖各种主题，包括： 1. 使用酵母的基础知识； 2.酵母分子生物学概论； 3. 遗传与身体相互作用分析； 4. 基因组学。课程的实验部分还辅以每日理论讲座，这些讲师是因其在该系统方面经过验证的专业知识而被选拔的，以及来自利用酵母系统的著名研究人员的世界级研讨会系列。因此，每个学生都能接触到所教授方法的基本原理以及该领域专家的最新应用。该课程享有良好的声誉，并致力于继续为多元化的生物学家社区提供服务，其中包括来自进化生物学、定量生物学等不同背景的科学家，以及在其他系统中工作的生物学家，这些系统可以证明从该课程中明显受益酵母的利用，因为有大量资源可用于这种模式生物的功能基因组研究。此外，寻求将酵母方法纳入本科课程的教育工作者也是该课程的偶尔学生。尽管课程的总体组织每年都保持不变，但随着酵母生物学和基因组学广泛领域的变化，内容也会自然演变；随着教师的更换（每年约 1 名），新的专业知识会添加到课程中，并且新教师会将最新的技术和方法纳入课程中。由于每年至少有两名教练留任，这种演变不会以牺牲连续性为代价。