Genomics Core

基因组学核心

• 批准号: 10708029
• 负责人: Donald Anthony Primerano
• 金额: $ 13.56万
• 依托单位: MARSHALL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10708029
• 关键词: Address; Adopted; Award; Bioinformatics; Biomedical Research; Businesses; CLC Gene; Chromatin; Chronic Disease; Client; Collaborations; Computer software; Consultations; Core Facility; DNA; DNA sequencing; Data; Data Analyses; Disease; Educational workshop; Experimental Designs; Expression Profiling; Genome; Genomic approach; Genomics; Genotype; Goals; Grant; High-Throughput Nucleotide Sequencing; Institution; Investigation; Lead; Libraries; Methods; Modeling; Molecular; Nucleic Acids; Pathway Analysis; Productivity; RNA; RNA Sequence Analysis; Reader; Research; Research Personnel; Research Project Grants; Resources; Science; Service delivery model; Services; Spectrophotometry; Strategic Planning; Technology; Time; Training; Universities; Variant; West Virginia; Work; cost effective; design; exome; experience; experimental study; genomic data; instrumentation; microbiome; next generation sequencing; operation; programs; transcriptome sequencing; undergraduate student; whole genome

Genomics Core Abstract The Genomics Core is a centralized resource which provides genomic research services, access to genomic and nucleic acid analysis instrumentation, and support for the analysis of genomic data. The Genomics Core will offer its services in support of the proposed WV-INBRE network and its investigators. In collaboration with the Bioinformatics Core, we propose to provide genomics services that are needed by lead and undergraduate investigators. These services include (1) high throughput next generation sequencing (NGS) to support whole genome, whole exome, RNA-Seq, microbiome and global chromatin studies, (2) experimental design and bioinformatic guidance and analysis for genomic projects, (3) access to DNA/RNA sequence analysis software, (4) automated Sanger DNA sequencing and genotyping and RNA/DNA quality assessment, and (5) access to shared instrumentation used in basic genomic analysis. These services are most efficiently executed in a core facility with expertise in genomic analysis. To insure that WV-INBRE investigators can take advantage of NGS technologies and design robust experiments, the Genomics Core will also provide training in genomic methods which will include workshops on existing and emerging next generation sequencing methods as well as one on consultation. The Genomics Core business model includes a full-service plan of operation for provision of NGS and other genomic services. We anticipate that our model and guidance from our experienced staff will allow WV-INBRE investigators to successfully adopt genomic approaches in their research and generate useful data. In the long term, their findings will lead to an understanding of the molecular basis of chronic diseases common in West Virginia and ultimately to treatments for these diseases. Dr. Donald Primerano will serve as the Genomics Core Director and Dr. Jun Fan will serve as the Core Manager. The Genomics Core was established at Marshall University in 1999 and has been supported by federal grants continuously since 2000.

基因组学核心摘要 基因组核心是一种集中资源，可提供基因组研究服务，访问 用于基因组和核酸分析仪器，并支持基因组数据的分析。这 Genomics Core将提供其服务，以支持拟议的WV-INBRE网络及其研究人员。 与生物信息学核心合作，我们建议提供所需的基因组服务 由领导和本科调查员。这些服务包括（1）高吞吐量下一代 测序（NGS）支持全基因组，整个外显子，RNA-Seq，微生物组和全局染色质 研究，（2）基因组项目的实验设计和生物信息学指导和分析，（3）访问 到DNA/RNA序列分析软件，（4）自动Sanger DNA测序和基因分型和 RNA/DNA质量评估以及（5）访问基本基因组分析中使用的共享仪器。 这些服务最有效地在具有基因组分析专业知识的核心设施中执行。到 确保WV INBRE调查人员可以利用NGS技术并设计强大 实验，基因组核心还将提供基因组方法的培训，其中包括 关于现有和新兴下一代测序方法的讲习班，以及 咨询。基因组学核心业务模型包括提供提供的全方位服务计划 NGS和其他基因组服务。我们预计我们经验丰富的模型和指导 员工将允许WV造成的调查人员在其研究中成功采用基因组方法 生成有用的数据。从长远来看，他们的发现将导致对分子基础的理解 西弗吉尼亚州常见的慢性疾病，最终对这些疾病的治疗方法。唐纳德博士 Primerano将担任基因组核心总监，Jun Fan博士将担任核心经理。 基因组学核心于1999年在马歇尔大学成立，并得到了联邦的支持 自2000年以来一直在赠款。