Mentoring the next generation of researchers at the intersection of opioid use disorder and chronic pain

指导下一代研究人员研究阿片类药物使用障碍和慢性疼痛的交叉点

• 批准号: 10663642
• 负责人: Jessica S Merlin
• 金额: $ 19.26万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663642
• 关键词: Active Learning; Address; Adopted; Adoption; Advanced Malignant Neoplasm; Alcohols; Area; Award; Behavior; Behavioral; Buprenorphine; Cancer Pain Management; Clinic; Clinical; Cocaine; Complication; Data; Development Plans; Diagnosis; Discipline; Disease Management; Disseminated Malignant Neoplasm; Doctor of Philosophy; Education; Equity; Evaluation; Faculty; Funding; Goals; HIV; Health; Helping to End Addiction Long-term; High Prevalence; Hybrids; Individual; Institution; Interview; Language; Leadership; Learning; Life; Life Experience; Maintenance; Malignant Neoplasms; Maps; Mentors; Methadone; Needs Assessment; Oncology; Opioid; Opioid agonist; Outcome; Pain; Pain management; Palliative Care; Participant; Pathway interactions; Patient Care; Patients; Perception; Performance; Personal Satisfaction; Persons; Physicians; Population; Postdoctoral Fellow; Primary Care; Productivity; Prognosis; Racial Equity; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Research; Research Methodology; Research Personnel; Research Project Grants; Research Proposals; Resources; Risk; Risk Factors; Science; Scientist; Sickle Cell; Specific qualifier value; Standardization; Testing; Tobacco use; Training; Translations; United States National Institutes of Health; Woman; Work; acceptability and feasibility; addiction; cancer care; career; career development; case-based; chronic abdominal pain; chronic pain; chronic pain patient; clinical practice; comorbidity; data submission; design; doctoral student; effectiveness outcome; effectiveness/implementation hybrid; evidence base; evidence based guidelines; experience; health equity; hybrid type 2 trial; implementation barriers; implementation evaluation; implementation facilitators; implementation framework; implementation protocol; implementation science; implementation strategy; improved; medication for opioid use disorder; next generation; novel; opioid misuse; opioid overdose; opioid use disorder; pilot trial; prescription opioid; programs; racial disparity; racial health disparity; randomized trial; recruit; research to practice; skills; social stigma; substance use; symposium; systematic review; treatment optimization; treatment research

Project Summary/Abstract: My overall goal is to improve the health and well-being of individuals with comorbid opioid misuse/opioid use disorder (OUD) and chronic pain across varied settings and populations. Research on the management of comorbid opioid misuse/OUD and chronic pain is being outpaced by the clinical need across populations and settings. Additionally, there is no well-worn training pathway to conduct research in this area, few mid-career and senior investigators have the expertise to mentor early-career investigators in this space, and the need for mentoring to grow the workforce is enormous. Finally, given the known racial health disparities in our field, it is especially important that researchers are representative of the populations they serve, which is currently not the case. I am a physician and PhD-trained behavioral scientist who treats individuals with opioid misuse/OUD and chronic pain. I have a consistent track record of NIH-funded research and productive mentoring at the intersection of these conditions across populations and settings including HIV, cancer, and primary care, and am at an institution with exceptional resources to support trainees. This K24 mid-career investigator award will allow me to grow the workforce at the intersection of opioid misuse/OUD and chronic pain by 1) expanding my capacity to mentor PhD students, postdoctoral scholars, and faculty from diverse disciplines—and allow me to continue to focus on women and individuals from backgrounds that are underrepresented in science—in research on comorbid opioid misuse/OUD and chronic pain; 2) Become a leader in implementation science approaches to studying treatment of comorbid opioid misuse/OUD and chronic pain, including hybrid trials; and 3) Develop the skills needed to systematically incorporate health equity considerations and research methods throughout my work. I have assembled a team of advisors with whom I have created a comprehensive career development plan including didactic coursework, experiential learning, and conference attendance that will allow me to excel at achieving these goals. Additionally, this K24 proposes a new research project that leverages existing Delphi-based preliminary data to 1) Develop an implementation strategy bundle to promote the adoption and equitable application of evidence-based approaches for managing opioid misuse/OUD and metastatic cancer-related pain, and 2) Conduct a hybrid type 2 pilot trial of the evidence-based approaches and implementation strategy bundle. Findings from this study will lead to a hybrid type 2 randomized trial of the implementation strategy bundle and ultimately improved care for patients with opioid misuse/OUD and metastatic cancer. This and other NIH- funded studies in my portfolio will provide mentees ample opportunity to propose mentored research projects. This mentored research experience, combined with a program of tailored career development opportunities, will develop a new cadre of independent investigators at the intersection of opioid misuse/OUD and chronic pain.

项目摘要/摘要：我的总体目标是改善个人的健康和福祉 在各种环境和人群之间，合并症阿片类药物滥用/阿片类药物使用障碍（OUD）和慢性疼痛。 对合并症的MISERIS/OUD和慢性疼痛的管理的研究已超过 人群和环境之间的临床需求。此外，没有做得好的训练途径 在这一领域的研究，很少有职业和高级研究人员拥有精神早期职业的专业知识 这个空间中的调查人员以及对劳动力发展的心理需求是巨大的。最后，给定 在我们领域的已知种族健康差异，研究人员代表研究人员尤其重要 他们服务的种群，目前不是这样。我是一名身体和博士训练的行为科学家 他患有阿片类Missuse/Oud和慢性疼痛的人。我拥有NIH资助的一致记录 这些条件在人群和环境之间的交集的研究和产品心理 包括艾滋病毒，癌症和初级保健，以及拥有卓越资源的机构 学员。这项K24中级调查员奖将使我能够在交叉路口增加劳动力 阿片类型MISSUSE/OUD和慢性疼痛到1）扩大我的精神博士学位学生的能力，博士后 来自潜水学科的学者和教职员工，并允许我继续专注于妇女和个人 从科学领域不足的背景来看，在研究合并的oid missuse/oud和 慢性疼痛； 2）成为研究合并治疗的实施科学方法的领导者 阿片类药物/OUD和慢性疼痛，包括混合试验； 3）发展系统地所需的技能 在我的整个工作中纳入了健康公平的注意事项和研究方法。我已经组建了一个团队 我与之制定了全面的职业发展计划的顾问 课程工作，经验丰富的学习和会议出勤，这将使我能够擅长实现这些 目标。此外，该K24提出了一个新的研究项目，该项目利用现有的基于Delphi的初步 数据到1）制定实施策略捆绑包，以促进采用和公平应用 用于管理阿片类药物的循证方法/OUD和转移性癌症相关疼痛的方法，以及2） 对基于证据的方法和实施策略捆绑进行混合2类试验试验。 这项研究的发现将导致实施策略捆绑包的混合2型随机试验和 最终改善了阿片类药物/OUD和转移性癌症患者的护理。这个和其他NIH- 在我的投资组合中获得的资助研究将为提出精明研究项目提供充足的机会。 这种修补了研究经验，再加上一个量身定制的职业发展机会计划， 将在阿片类Missuse/Oud和慢性的交叉点上发展一个新的独立研究人员干部 疼痛。