Promoting Diversity in Health-Related Research

促进健康相关研究的多样性

• 批准号: 10721795
• 负责人: Stephen Mark Camarata
• 金额: $ 2.79万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-11-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10721795
• 关键词: 12 year old; Audiology; Auditory; Child; Childhood; Cochlear Implants; Collaborations; Enrollment; Generations; Health; Intervention; Language; Language Disorders; Literature; Measures; Monitor; Operative Surgical Procedures; Outcome; Participant; Pathologist; Patients; Production; Randomized; Research; Research Activity; Speech; Speech Disorders; Time; Waiting Lists; aged; follow-up; hearing impairment; image guided; implantation; improved; improved outcome; literacy; parent project; pediatric patients; reading comprehension; speech recognition; temporal measurement; therapy design

ABSTRACT FROM PARENT PROJECT (Image Guided Programming: Pediatric Speech, Language and Literacy) Although the recent literature has indicated that children receiving cochlear implants often have dramatically improved speech and language ability relative to previous generations of children with hearing loss, many pediatric cochlear implant (CI) patients display persistent speech and language disorders despite early implantation and associated speech/language intervention [see (1,2)]. There is a striking paucity and ongoing need for studies that systematically examine the relationship between surgical implantation parameters, audiological profile, and subsequent speech, language, and literacy outcomes in pediatric CI [see (3)]. The proposed project provides a unique opportunity to examine whether individualized, image-guided CI programming (IGCIP) significantly improves outcomes in pediatric CI patients. The proposed research is a collaboration between an audiologist (Gifford) and a speech language pathologist (Camarata) and a biostatistician (Dietrich). The proposed research activities will examine the impact of personalized IGCIP in pediatric patients on measures of basic auditory function (spectral and temporal resolution), speech recognition, speech production, language, and measures of preliteracy and reading comprehension using a randomized wait-list control treatment design. A total of 60 children with CIs aged six to twelve years old will be enrolled in the project and one-half (n = 30) will be randomized to an immediate IGCIP condition and half to a 12 month waitlist control condition. The waitlisted participants (n = 30) will undergo IGCIP after 12 months of monitoring and followed up for an additional 12 months after the programming has been provided (total time in the study: 24 months). Those immediately provided with IGCIP will also be enrolled for a total of 24 months. All participants will undergo extensive audiological and speech and language assessments in addition to comprehensive audiological assessment at baseline as well as at regular intervals: 2, 6, 12, 14, 18, and 24 months. We will use predictor analyses to determine the impact of immediate and deferred IGCIP on subsequent auditory, speech, language, and literacy outcomes.

家长项目摘要（图像引导编程：儿科语音， 语言和读写能力） 尽管最近的文献表明接受人工耳蜗植入的儿童通常会出现 与前几代儿童相比，言语和语言能力显着提高 由于听力损失，许多儿童人工耳蜗 (CI) 患者表现出持续言语和 尽管存在早期植入和相关的言语/语言干预，但仍存在语言障碍 [参见(1,2)]。系统地检验的研究非常缺乏并且持续存在需求 手术植入参数、听力学特征和后续治疗之间的关系 儿科 CI 的言语、语言和识字结果[见 (3)]。拟议项目 提供了一个独特的机会来检查个性化、图像引导的 CI 是否 编程 (IGCIP) 显着改善儿科 CI 患者的预后。拟议的 研究是听力学家（吉福德）和言语病理学家之间的合作 （卡马拉塔）和生物统计学家（迪特里希）。拟议的研究活动将审查 儿科患者个性化 IGCIP 对基本听觉功能测量的影响 （频谱和时间分辨率）、语音识别、语音生成、语言和 使用随机等候名单控制来衡量读写能力和阅读理解能力 治疗设计。共有 60 名 6 至 12 岁的 CI 儿童入读 该项目的一半 (n = 30) 将被随机分配到立即 IGCIP 条件，一半将被随机分配到 12 个月的候补名单控制条件。列入候补名单的参与者 (n = 30) 将接受 IGCIP 经过 12 个月的监测并在治疗后又进行了 12 个月的随访 已提供编程（研究总时间：24 个月）。那些立即 提供 IGCIP 的学生也将注册总共 24 个月。所有参与者都将经历 除了全面的听力、言语和语言评估之外 基线和定期听力学评估：2、6、12、14、18 和 24 几个月。我们将使用预测分析来确定立即和延迟的影响 IGCIP 关于随后的听觉、言语、语言和识字结果。